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Syncytiotrophoblast Vesicles Show Altered micro-RNA and Haemoglobin Content after Ex-vivo Perfusion of Placentas with Haemoglobin to Mimic Preeclampsia.

Cronqvist, Tina LU ; Saljé, Karen; Familari, Mary; Guller, Seth; Schneider, Henning; Gardiner, Chris; Sargent, Ian L; Redman, Christopher W; Mörgelin, Matthias LU and Åkerström, Bo LU , et al. (2014) In PLoS ONE 9(2).
Abstract
Cell-free foetal haemoglobin (HbF) has been shown to play a role in the pathology of preeclampsia (PE). In the present study, we aimed to further characterize the harmful effects of extracellular free haemoglobin (Hb) on the placenta. In particular, we investigated whether cell-free Hb affects the release of placental syncytiotrophoblast vesicles (STBMs) and their micro-RNA content.
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Contribution to journal
publication status
published
subject
in
PLoS ONE
volume
9
issue
2
publisher
Public Library of Science
external identifiers
  • pmid:24587192
  • wos:000332390800067
  • scopus:84896332786
ISSN
1932-6203
DOI
10.1371/journal.pone.0090020
language
English
LU publication?
yes
id
93ff4524-63ac-4841-9d2c-179096008140 (old id 4384090)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/24587192?dopt=Abstract
date added to LUP
2014-04-01 22:59:49
date last changed
2017-10-22 04:01:34
@article{93ff4524-63ac-4841-9d2c-179096008140,
  abstract     = {Cell-free foetal haemoglobin (HbF) has been shown to play a role in the pathology of preeclampsia (PE). In the present study, we aimed to further characterize the harmful effects of extracellular free haemoglobin (Hb) on the placenta. In particular, we investigated whether cell-free Hb affects the release of placental syncytiotrophoblast vesicles (STBMs) and their micro-RNA content.},
  articleno    = {e90020},
  author       = {Cronqvist, Tina and Saljé, Karen and Familari, Mary and Guller, Seth and Schneider, Henning and Gardiner, Chris and Sargent, Ian L and Redman, Christopher W and Mörgelin, Matthias and Åkerström, Bo and Gram, Magnus and Hansson, Stefan},
  issn         = {1932-6203},
  language     = {eng},
  number       = {2},
  publisher    = {Public Library of Science},
  series       = {PLoS ONE},
  title        = {Syncytiotrophoblast Vesicles Show Altered micro-RNA and Haemoglobin Content after Ex-vivo Perfusion of Placentas with Haemoglobin to Mimic Preeclampsia.},
  url          = {http://dx.doi.org/10.1371/journal.pone.0090020},
  volume       = {9},
  year         = {2014},
}