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Association of the oestrogen receptor beta with hormone status and prognosis in a cohort of female patients with colorectal cancer

Topi, Geriolda LU ; Ehrnström, Roy LU ; Jirström, Karin LU ; Palmquist, Ingrid LU ; Lydrup, Marie Louise LU and Sjölander, Anita LU (2017) In European Journal of Cancer 83. p.279-289
Abstract

Background The oestrogen receptor beta (ERβ) is the predominant oestrogen receptor in the normal colon mucosa and has been reported to exert anti-proliferative and pro-apoptotic effects. However, the role of ERβ in colorectal cancer (CRC) progression remains unclear. Aim To investigate the role of ERβ and its association with hormone status and lifestyle indicators in a female cohort of patients with CRC. Methods Tissue microarrays of primary CRC tumour samples from 320 female patients were conducted with a monoclonal anti-ERβ antibody. The staining intensity was evaluated using immunohistochemistry. The association of ERβ expression with overall survival, disease-free survival, hormone status and lifestyle was evaluated, and effect... (More)

Background The oestrogen receptor beta (ERβ) is the predominant oestrogen receptor in the normal colon mucosa and has been reported to exert anti-proliferative and pro-apoptotic effects. However, the role of ERβ in colorectal cancer (CRC) progression remains unclear. Aim To investigate the role of ERβ and its association with hormone status and lifestyle indicators in a female cohort of patients with CRC. Methods Tissue microarrays of primary CRC tumour samples from 320 female patients were conducted with a monoclonal anti-ERβ antibody. The staining intensity was evaluated using immunohistochemistry. The association of ERβ expression with overall survival, disease-free survival, hormone status and lifestyle was evaluated, and effect estimators with 95% confidence intervals (CIs) were reported. Results Among the 314 samples with successfully detected ERβ, 182 (58%) had low expression and 132 (42%) had high expression. The Cox multivariate analysis indicated that patients with high ERβ expression had a decreased risk of overall mortality by 50% (hazard ratio [HR], 0.50; CI, 0.30–0.83) and of cancer recurrence by 76% (HR, 0.24; CI, 0.11–0.52) after adjusting for age, tumour-node-metastasis stage and tumour intravascular invasion. Furthermore, high ERβ expression was significantly correlated with shorter breastfeeding time and longer use of hormone replacement therapy. No association was found between ERβ expression and lifestyle indicators. Conclusion Elevated ERβ expression is independently associated with a better prognosis and hormone status but not lifestyle indicators in female CRC patients.

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Contribution to journal
publication status
published
subject
keywords
Cancer prognosis, Colorectal cancer, Disease-free survival, Oestrogen receptor beta, Overall survival
in
European Journal of Cancer
volume
83
pages
11 pages
publisher
Elsevier
external identifiers
  • scopus:85026359143
  • wos:000408273800032
ISSN
0959-8049
DOI
10.1016/j.ejca.2017.06.013
language
English
LU publication?
yes
id
43c064b9-42a4-437e-b6ef-4ef7ea6c0cd5
date added to LUP
2017-08-22 16:11:35
date last changed
2017-09-18 11:42:43
@article{43c064b9-42a4-437e-b6ef-4ef7ea6c0cd5,
  abstract     = {<p>Background The oestrogen receptor beta (ERβ) is the predominant oestrogen receptor in the normal colon mucosa and has been reported to exert anti-proliferative and pro-apoptotic effects. However, the role of ERβ in colorectal cancer (CRC) progression remains unclear. Aim To investigate the role of ERβ and its association with hormone status and lifestyle indicators in a female cohort of patients with CRC. Methods Tissue microarrays of primary CRC tumour samples from 320 female patients were conducted with a monoclonal anti-ERβ antibody. The staining intensity was evaluated using immunohistochemistry. The association of ERβ expression with overall survival, disease-free survival, hormone status and lifestyle was evaluated, and effect estimators with 95% confidence intervals (CIs) were reported. Results Among the 314 samples with successfully detected ERβ, 182 (58%) had low expression and 132 (42%) had high expression. The Cox multivariate analysis indicated that patients with high ERβ expression had a decreased risk of overall mortality by 50% (hazard ratio [HR], 0.50; CI, 0.30–0.83) and of cancer recurrence by 76% (HR, 0.24; CI, 0.11–0.52) after adjusting for age, tumour-node-metastasis stage and tumour intravascular invasion. Furthermore, high ERβ expression was significantly correlated with shorter breastfeeding time and longer use of hormone replacement therapy. No association was found between ERβ expression and lifestyle indicators. Conclusion Elevated ERβ expression is independently associated with a better prognosis and hormone status but not lifestyle indicators in female CRC patients.</p>},
  author       = {Topi, Geriolda and Ehrnström, Roy and Jirström, Karin and Palmquist, Ingrid and Lydrup, Marie Louise and Sjölander, Anita},
  issn         = {0959-8049},
  keyword      = {Cancer prognosis,Colorectal cancer,Disease-free survival,Oestrogen receptor beta,Overall survival},
  language     = {eng},
  month        = {09},
  pages        = {279--289},
  publisher    = {Elsevier},
  series       = {European Journal of Cancer},
  title        = {Association of the oestrogen receptor beta with hormone status and prognosis in a cohort of female patients with colorectal cancer},
  url          = {http://dx.doi.org/10.1016/j.ejca.2017.06.013},
  volume       = {83},
  year         = {2017},
}