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Impact of sex on perinatal mortality and morbidity in twins

Elsmén, Emma LU ; Källén, Karin LU ; Marsal, Karel LU ; Norman, Mikael and Hellstrom-Westas, Lena (2014) In Journal of Perinatal Medicine 42(2). p.225-231
Abstract
Objective: Twin studies offer opportunities to investigate mechanisms underlying sex-associated differences in perinatal outcomes. The objective of the study was to investigate sex-related differences in perinatal complications. Study design: A cohort of 16,045 twin pregnancies 32,090 twins - was explored for obstetric complications, perinatal and infant mortality, and neonatal morbidities. Results: Twin pregnancies with a female fetus had an increased risk for preeclampsia, but otherwise there were no pregnancy complications associated with fetal sex. After birth, female-female twins had lower early neonatal and infant mortality, and lower risk for respiratory morbidities than male-male twins at all gestational ages. In unlike-sexed twin... (More)
Objective: Twin studies offer opportunities to investigate mechanisms underlying sex-associated differences in perinatal outcomes. The objective of the study was to investigate sex-related differences in perinatal complications. Study design: A cohort of 16,045 twin pregnancies 32,090 twins - was explored for obstetric complications, perinatal and infant mortality, and neonatal morbidities. Results: Twin pregnancies with a female fetus had an increased risk for preeclampsia, but otherwise there were no pregnancy complications associated with fetal sex. After birth, female-female twins had lower early neonatal and infant mortality, and lower risk for respiratory morbidities than male-male twins at all gestational ages. In unlike-sexed twin pairs, very preterm males had higher respiratory morbidity than females and, females were at higher risk for being growth restricted. Conclusion: Male-male twins have higher respiratory morbidity and neonatal mortality than female-female twins. In unliked-sexed twin pairs, the males seem to be protected by having a female co-twin. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Growth restriction, newborn, respiratory morbidity, preeclampsia, preterm
in
Journal of Perinatal Medicine
volume
42
issue
2
pages
225 - 231
publisher
De Gruyter
external identifiers
  • wos:000332843500011
  • scopus:84898654897
ISSN
1619-3997
DOI
10.1515/jpm-2013-0147
language
English
LU publication?
yes
id
39712943-5ea7-455d-9d57-9bc57dc6f761 (old id 4411082)
date added to LUP
2014-05-05 07:17:23
date last changed
2017-10-29 03:20:51
@article{39712943-5ea7-455d-9d57-9bc57dc6f761,
  abstract     = {Objective: Twin studies offer opportunities to investigate mechanisms underlying sex-associated differences in perinatal outcomes. The objective of the study was to investigate sex-related differences in perinatal complications. Study design: A cohort of 16,045 twin pregnancies 32,090 twins - was explored for obstetric complications, perinatal and infant mortality, and neonatal morbidities. Results: Twin pregnancies with a female fetus had an increased risk for preeclampsia, but otherwise there were no pregnancy complications associated with fetal sex. After birth, female-female twins had lower early neonatal and infant mortality, and lower risk for respiratory morbidities than male-male twins at all gestational ages. In unlike-sexed twin pairs, very preterm males had higher respiratory morbidity than females and, females were at higher risk for being growth restricted. Conclusion: Male-male twins have higher respiratory morbidity and neonatal mortality than female-female twins. In unliked-sexed twin pairs, the males seem to be protected by having a female co-twin.},
  author       = {Elsmén, Emma and Källén, Karin and Marsal, Karel and Norman, Mikael and Hellstrom-Westas, Lena},
  issn         = {1619-3997},
  keyword      = {Growth restriction,newborn,respiratory morbidity,preeclampsia,preterm},
  language     = {eng},
  number       = {2},
  pages        = {225--231},
  publisher    = {De Gruyter},
  series       = {Journal of Perinatal Medicine},
  title        = {Impact of sex on perinatal mortality and morbidity in twins},
  url          = {http://dx.doi.org/10.1515/jpm-2013-0147},
  volume       = {42},
  year         = {2014},
}