The outer membrane protein OlpA contributes to Moraxella catarrhalis serum resistance via interaction with factor H and the alternative pathway.
(2014) In Journal of Infectious Diseases 210(8). p.1306-1310- Abstract
- Factor H is an important complement regulator of the alternative pathway commonly recruited by pathogens for increased survival in the human host. The respiratory pathogen Moraxella catarrhalis that resides in the mucosa is highly serum resistant and causes otitis media in children and respiratory tract infections in individuals with underlying diseases. In this study, we show that M. catarrhalis binds factor H via the outer membrane protein OlpA. M. catarrhalis serum resistance was dramatically decreased in the absence of either OlpA or factor H, demonstrating that this inhibition of the alternative pathway significantly contributes to the virulence of M. catarrhalis.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/4429388
- author
- Bernhard, Sara
LU
; Fleury, Christophe
LU
; Su, Shanice YC
LU
; Zipfel, Peter
; Koske, Iris
; Nordström, Therése
LU
and Riesbeck, Kristian
LU
- organization
- publishing date
- 2014
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Journal of Infectious Diseases
- volume
- 210
- issue
- 8
- pages
- 1306 - 1310
- publisher
- Oxford University Press
- external identifiers
-
- pmid:24771863
- wos:000344609600016
- scopus:84910011400
- pmid:24771863
- ISSN
- 1537-6613
- DOI
- 10.1093/infdis/jiu241
- language
- English
- LU publication?
- yes
- id
- 295670d1-e441-4401-b10c-eb73d462499b (old id 4429388)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/24771863?dopt=Abstract
- date added to LUP
- 2016-04-01 09:48:43
- date last changed
- 2022-01-25 08:58:53
@article{295670d1-e441-4401-b10c-eb73d462499b, abstract = {{Factor H is an important complement regulator of the alternative pathway commonly recruited by pathogens for increased survival in the human host. The respiratory pathogen Moraxella catarrhalis that resides in the mucosa is highly serum resistant and causes otitis media in children and respiratory tract infections in individuals with underlying diseases. In this study, we show that M. catarrhalis binds factor H via the outer membrane protein OlpA. M. catarrhalis serum resistance was dramatically decreased in the absence of either OlpA or factor H, demonstrating that this inhibition of the alternative pathway significantly contributes to the virulence of M. catarrhalis.}}, author = {{Bernhard, Sara and Fleury, Christophe and Su, Shanice YC and Zipfel, Peter and Koske, Iris and Nordström, Therése and Riesbeck, Kristian}}, issn = {{1537-6613}}, language = {{eng}}, number = {{8}}, pages = {{1306--1310}}, publisher = {{Oxford University Press}}, series = {{Journal of Infectious Diseases}}, title = {{The outer membrane protein OlpA contributes to Moraxella catarrhalis serum resistance via interaction with factor H and the alternative pathway.}}, url = {{https://lup.lub.lu.se/search/files/1273548/4926912.pdf}}, doi = {{10.1093/infdis/jiu241}}, volume = {{210}}, year = {{2014}}, }