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The outer membrane protein OlpA contributes to Moraxella catarrhalis serum resistance via interaction with factor H and the alternative pathway.

Bernhard, Sara LU ; Fleury, Christophe LU ; Su, Shanice YC LU ; Zipfel, Peter; Koske, Iris; Nordström, Therése LU and Riesbeck, Kristian LU (2014) In Journal of Infectious Diseases 210(8). p.1306-1310
Abstract
Factor H is an important complement regulator of the alternative pathway commonly recruited by pathogens for increased survival in the human host. The respiratory pathogen Moraxella catarrhalis that resides in the mucosa is highly serum resistant and causes otitis media in children and respiratory tract infections in individuals with underlying diseases. In this study, we show that M. catarrhalis binds factor H via the outer membrane protein OlpA. M. catarrhalis serum resistance was dramatically decreased in the absence of either OlpA or factor H, demonstrating that this inhibition of the alternative pathway significantly contributes to the virulence of M. catarrhalis.
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Infectious Diseases
volume
210
issue
8
pages
1306 - 1310
publisher
Oxford University Press
external identifiers
  • pmid:24771863
  • wos:000344609600016
  • scopus:84910011400
ISSN
1537-6613
DOI
10.1093/infdis/jiu241
language
English
LU publication?
yes
id
295670d1-e441-4401-b10c-eb73d462499b (old id 4429388)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/24771863?dopt=Abstract
date added to LUP
2014-05-02 23:20:24
date last changed
2017-11-12 03:00:20
@article{295670d1-e441-4401-b10c-eb73d462499b,
  abstract     = {Factor H is an important complement regulator of the alternative pathway commonly recruited by pathogens for increased survival in the human host. The respiratory pathogen Moraxella catarrhalis that resides in the mucosa is highly serum resistant and causes otitis media in children and respiratory tract infections in individuals with underlying diseases. In this study, we show that M. catarrhalis binds factor H via the outer membrane protein OlpA. M. catarrhalis serum resistance was dramatically decreased in the absence of either OlpA or factor H, demonstrating that this inhibition of the alternative pathway significantly contributes to the virulence of M. catarrhalis.},
  author       = {Bernhard, Sara and Fleury, Christophe and Su, Shanice YC and Zipfel, Peter and Koske, Iris and Nordström, Therése and Riesbeck, Kristian},
  issn         = {1537-6613},
  language     = {eng},
  number       = {8},
  pages        = {1306--1310},
  publisher    = {Oxford University Press},
  series       = {Journal of Infectious Diseases},
  title        = {The outer membrane protein OlpA contributes to Moraxella catarrhalis serum resistance via interaction with factor H and the alternative pathway.},
  url          = {http://dx.doi.org/10.1093/infdis/jiu241},
  volume       = {210},
  year         = {2014},
}