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The age and genomic integrity of neurons after cortical stroke in humans.

Huttner, Hagen B; Bergmann, Olaf; Salehpour, Mehran; Rácz, Attila; Tatarishvili, Jemal LU ; Lindgren, Emma; Csonka, Tamás; Csiba, László; Hortobágyi, Tibor and Méhes, Gábor, et al. (2014) In Nature Neuroscience 17(6). p.801-803
Abstract
It has been unclear whether ischemic stroke induces neurogenesis or neuronal DNA rearrangements in the human neocortex. Using immunohistochemistry; transcriptome, genome and ploidy analyses; and determination of nuclear bomb test-derived (14)C concentration in neuronal DNA, we found neither to be the case. A large proportion of cortical neurons displayed DNA fragmentation and DNA repair a short time after stroke, whereas neurons at chronic stages after stroke showed DNA integrity, demonstrating the relevance of an intact genome for survival.
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Contribution to journal
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published
subject
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Nature Neuroscience
volume
17
issue
6
pages
801 - 803
publisher
Nature Publishing Group
external identifiers
  • pmid:24747576
  • wos:000336638000013
  • scopus:84901670239
ISSN
1546-1726
DOI
10.1038/nn.3706
language
English
LU publication?
yes
id
44b27ed0-0d59-44d5-8c9e-b43fdf67f3a7 (old id 4429760)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/24747576?dopt=Abstract
date added to LUP
2014-05-05 13:27:19
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2017-08-13 03:24:26
@article{44b27ed0-0d59-44d5-8c9e-b43fdf67f3a7,
  abstract     = {It has been unclear whether ischemic stroke induces neurogenesis or neuronal DNA rearrangements in the human neocortex. Using immunohistochemistry; transcriptome, genome and ploidy analyses; and determination of nuclear bomb test-derived (14)C concentration in neuronal DNA, we found neither to be the case. A large proportion of cortical neurons displayed DNA fragmentation and DNA repair a short time after stroke, whereas neurons at chronic stages after stroke showed DNA integrity, demonstrating the relevance of an intact genome for survival.},
  author       = {Huttner, Hagen B and Bergmann, Olaf and Salehpour, Mehran and Rácz, Attila and Tatarishvili, Jemal and Lindgren, Emma and Csonka, Tamás and Csiba, László and Hortobágyi, Tibor and Méhes, Gábor and Englund, Elisabet and Solnestam, Beata Werne and Zdunek, Sofia and Scharenberg, Christian and Ström, Lena and Ståhl, Patrik and Sigurgeirsson, Benjamin and Dahl, Andreas and Schwab, Stefan and Possnert, Göran and Bernard, Samuel and Kokaia, Zaal and Lindvall, Olle and Lundeberg, Joakim and Frisén, Jonas},
  issn         = {1546-1726},
  language     = {eng},
  number       = {6},
  pages        = {801--803},
  publisher    = {Nature Publishing Group},
  series       = {Nature Neuroscience},
  title        = {The age and genomic integrity of neurons after cortical stroke in humans.},
  url          = {http://dx.doi.org/10.1038/nn.3706},
  volume       = {17},
  year         = {2014},
}