The age and genomic integrity of neurons after cortical stroke in humans.
(2014) In Nature Neuroscience 17(6). p.801-803- Abstract
- It has been unclear whether ischemic stroke induces neurogenesis or neuronal DNA rearrangements in the human neocortex. Using immunohistochemistry; transcriptome, genome and ploidy analyses; and determination of nuclear bomb test-derived (14)C concentration in neuronal DNA, we found neither to be the case. A large proportion of cortical neurons displayed DNA fragmentation and DNA repair a short time after stroke, whereas neurons at chronic stages after stroke showed DNA integrity, demonstrating the relevance of an intact genome for survival.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/4429760
- author
- Huttner, Hagen B
; Bergmann, Olaf
; Salehpour, Mehran
; Rácz, Attila
; Tatarishvili, Jemal
LU
; Lindgren, Emma
; Csonka, Tamás
; Csiba, László
; Hortobágyi, Tibor
; Méhes, Gábor
; Englund, Elisabet
LU
; Solnestam, Beata Werne
; Zdunek, Sofia
; Scharenberg, Christian
; Ström, Lena
; Ståhl, Patrik
; Sigurgeirsson, Benjamin
; Dahl, Andreas
; Schwab, Stefan
; Possnert, Göran
; Bernard, Samuel
; Kokaia, Zaal
LU
; Lindvall, Olle
LU
; Lundeberg, Joakim
and Frisén, Jonas
(Less) - organization
- publishing date
- 2014
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Nature Neuroscience
- volume
- 17
- issue
- 6
- pages
- 801 - 803
- publisher
- Nature Publishing Group
- external identifiers
-
- pmid:24747576
- wos:000336638000013
- scopus:84901670239
- pmid:24747576
- ISSN
- 1546-1726
- DOI
- 10.1038/nn.3706
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Pathology, (Lund) (013030000), Neurology, Lund (013027000)
- id
- 44b27ed0-0d59-44d5-8c9e-b43fdf67f3a7 (old id 4429760)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/24747576?dopt=Abstract
- date added to LUP
- 2016-04-01 11:07:09
- date last changed
- 2025-04-04 14:46:47
@article{44b27ed0-0d59-44d5-8c9e-b43fdf67f3a7,
abstract = {{It has been unclear whether ischemic stroke induces neurogenesis or neuronal DNA rearrangements in the human neocortex. Using immunohistochemistry; transcriptome, genome and ploidy analyses; and determination of nuclear bomb test-derived (14)C concentration in neuronal DNA, we found neither to be the case. A large proportion of cortical neurons displayed DNA fragmentation and DNA repair a short time after stroke, whereas neurons at chronic stages after stroke showed DNA integrity, demonstrating the relevance of an intact genome for survival.}},
author = {{Huttner, Hagen B and Bergmann, Olaf and Salehpour, Mehran and Rácz, Attila and Tatarishvili, Jemal and Lindgren, Emma and Csonka, Tamás and Csiba, László and Hortobágyi, Tibor and Méhes, Gábor and Englund, Elisabet and Solnestam, Beata Werne and Zdunek, Sofia and Scharenberg, Christian and Ström, Lena and Ståhl, Patrik and Sigurgeirsson, Benjamin and Dahl, Andreas and Schwab, Stefan and Possnert, Göran and Bernard, Samuel and Kokaia, Zaal and Lindvall, Olle and Lundeberg, Joakim and Frisén, Jonas}},
issn = {{1546-1726}},
language = {{eng}},
number = {{6}},
pages = {{801--803}},
publisher = {{Nature Publishing Group}},
series = {{Nature Neuroscience}},
title = {{The age and genomic integrity of neurons after cortical stroke in humans.}},
url = {{http://dx.doi.org/10.1038/nn.3706}},
doi = {{10.1038/nn.3706}},
volume = {{17}},
year = {{2014}},
}