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Desmopressin in treatment of haematological disorders and in prevention of surgical bleeding.

Svensson, Peter LU ; Bergqvist, Peter B F; Juul, Kristian Vinter and Berntorp, Erik LU (2014) In Blood Reviews 28(3). p.95-102
Abstract
Stimulation with the vasopressin analogue desmopressin (DDAVP) of extrarenal arginine vasopressin (AVP) V2-receptors in endothelial cells and possible in platelets increases the circulating levels of coagulation factor VIII (FVIII), von Willebrand factor (VWF) and tissue plasminogen activator (t-PA). The purpose of this paper is to provide an updated review of current information on the efficacy and safety of DDAVP in the treatment of haemophilia, von Willebrand disease (VWD), uremia, liver cirrhosis, and in congenital or drug-induced platelet dysfunction - under surgical or non-surgical conditions. In summary, desmopressin is an effective haemostatic drug that when administered i.v., s.c. or intranasally increases plasma levels of FVIII... (More)
Stimulation with the vasopressin analogue desmopressin (DDAVP) of extrarenal arginine vasopressin (AVP) V2-receptors in endothelial cells and possible in platelets increases the circulating levels of coagulation factor VIII (FVIII), von Willebrand factor (VWF) and tissue plasminogen activator (t-PA). The purpose of this paper is to provide an updated review of current information on the efficacy and safety of DDAVP in the treatment of haemophilia, von Willebrand disease (VWD), uremia, liver cirrhosis, and in congenital or drug-induced platelet dysfunction - under surgical or non-surgical conditions. In summary, desmopressin is an effective haemostatic drug that when administered i.v., s.c. or intranasally increases plasma levels of FVIII and VWF 2-6 times and improves platelet function. It has a proven haemostatic efficacy in mild haemophilia A and VWD as well as in uremia, liver cirrhosis and in congenital and acquired, drug induced platelet dysfunction. Desmopressin has few side effects but observation is advised in small children and elderly. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Blood Reviews
volume
28
issue
3
pages
95 - 102
publisher
Churchill Livingstone
external identifiers
  • wos:000337207100002
  • pmid:24703870
  • scopus:84900849295
ISSN
1532-1681
DOI
10.1016/j.blre.2014.03.001
language
English
LU publication?
yes
id
115f6324-d5c5-4b16-adf5-ed491359e36c (old id 4430811)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/24703870?dopt=Abstract
date added to LUP
2014-05-06 19:56:22
date last changed
2017-11-12 03:09:37
@article{115f6324-d5c5-4b16-adf5-ed491359e36c,
  abstract     = {Stimulation with the vasopressin analogue desmopressin (DDAVP) of extrarenal arginine vasopressin (AVP) V2-receptors in endothelial cells and possible in platelets increases the circulating levels of coagulation factor VIII (FVIII), von Willebrand factor (VWF) and tissue plasminogen activator (t-PA). The purpose of this paper is to provide an updated review of current information on the efficacy and safety of DDAVP in the treatment of haemophilia, von Willebrand disease (VWD), uremia, liver cirrhosis, and in congenital or drug-induced platelet dysfunction - under surgical or non-surgical conditions. In summary, desmopressin is an effective haemostatic drug that when administered i.v., s.c. or intranasally increases plasma levels of FVIII and VWF 2-6 times and improves platelet function. It has a proven haemostatic efficacy in mild haemophilia A and VWD as well as in uremia, liver cirrhosis and in congenital and acquired, drug induced platelet dysfunction. Desmopressin has few side effects but observation is advised in small children and elderly.},
  author       = {Svensson, Peter and Bergqvist, Peter B F and Juul, Kristian Vinter and Berntorp, Erik},
  issn         = {1532-1681},
  language     = {eng},
  number       = {3},
  pages        = {95--102},
  publisher    = {Churchill Livingstone},
  series       = {Blood Reviews},
  title        = {Desmopressin in treatment of haematological disorders and in prevention of surgical bleeding.},
  url          = {http://dx.doi.org/10.1016/j.blre.2014.03.001},
  volume       = {28},
  year         = {2014},
}