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Risk of cancer in patients with medically diagnosed hay fever or allergic rhinitis.

Hemminki, Kari LU ; Försti, Asta LU ; Fallah, Mahdi LU ; Sundquist, Jan LU ; Sundquist, Kristina LU and Ji, Jianguang LU (2014) In International Journal of Cancer 135(10). p.2397-2403
Abstract
Data on allergic conditions as risk or protective factors for cancer are controversial probably because most studies have used self-reported data on mixed groups of allergies in a case-control setting. We define cancer risks in medically diagnosed hay fever/allergic rhinitis patients in a nationwide cohort study. A total of 138,723 hay fever/allergic rhinitis patients were identified from three Swedish health care databases and standardized incidence ratios (SIRs) were calculated for subsequent cancers identified from the Swedish Cancer Registry. Overall cancer risk was not changed (SIR 1.03). For individual cancers, the highest SIR was observed for nasal cancer (SIR 2.63), followed by testicular (1.46) and endocrine tumors (1.42), and... (More)
Data on allergic conditions as risk or protective factors for cancer are controversial probably because most studies have used self-reported data on mixed groups of allergies in a case-control setting. We define cancer risks in medically diagnosed hay fever/allergic rhinitis patients in a nationwide cohort study. A total of 138,723 hay fever/allergic rhinitis patients were identified from three Swedish health care databases and standardized incidence ratios (SIRs) were calculated for subsequent cancers identified from the Swedish Cancer Registry. Overall cancer risk was not changed (SIR 1.03). For individual cancers, the highest SIR was observed for nasal cancer (SIR 2.63), followed by testicular (1.46) and endocrine tumors (1.42), and kidney (1.31), prostate (1.18) and breast (1.11) cancers. The results were consistent in the three sources of data and all SIRs were above unity, albeit mainly not statistically significant. The SIRs for nervous system tumors were above unity and of borderline significance. SIRs were decreased for esophageal (0.50), liver (0.62) and lung (0.78) cancers, and the three sources of data agreed in the direction of the effect. The increased risks for testicular, renal, prostate and endocrine cancers may be explained by immunological mechanisms. Excess risk for these cancer accounts for a significant population attributable fraction. Nervous system cancers showed a borderline increase and none of the histological types were significantly decreased, providing strong evidence against the published case-control studies, which have reported protective effects. The reasons for the reduced risks for esophageal, liver and lung cancer remain to be explained. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
International Journal of Cancer
volume
135
issue
10
pages
2397 - 2403
publisher
John Wiley & Sons
external identifiers
  • pmid:24692097
  • wos:000341984500019
  • scopus:84909950186
ISSN
0020-7136
DOI
10.1002/ijc.28873
language
English
LU publication?
yes
id
f33c942a-5c9b-4c3d-869e-954234a8cb3c (old id 4431294)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/24692097?dopt=Abstract
date added to LUP
2014-05-07 17:47:14
date last changed
2017-07-30 03:06:49
@article{f33c942a-5c9b-4c3d-869e-954234a8cb3c,
  abstract     = {Data on allergic conditions as risk or protective factors for cancer are controversial probably because most studies have used self-reported data on mixed groups of allergies in a case-control setting. We define cancer risks in medically diagnosed hay fever/allergic rhinitis patients in a nationwide cohort study. A total of 138,723 hay fever/allergic rhinitis patients were identified from three Swedish health care databases and standardized incidence ratios (SIRs) were calculated for subsequent cancers identified from the Swedish Cancer Registry. Overall cancer risk was not changed (SIR 1.03). For individual cancers, the highest SIR was observed for nasal cancer (SIR 2.63), followed by testicular (1.46) and endocrine tumors (1.42), and kidney (1.31), prostate (1.18) and breast (1.11) cancers. The results were consistent in the three sources of data and all SIRs were above unity, albeit mainly not statistically significant. The SIRs for nervous system tumors were above unity and of borderline significance. SIRs were decreased for esophageal (0.50), liver (0.62) and lung (0.78) cancers, and the three sources of data agreed in the direction of the effect. The increased risks for testicular, renal, prostate and endocrine cancers may be explained by immunological mechanisms. Excess risk for these cancer accounts for a significant population attributable fraction. Nervous system cancers showed a borderline increase and none of the histological types were significantly decreased, providing strong evidence against the published case-control studies, which have reported protective effects. The reasons for the reduced risks for esophageal, liver and lung cancer remain to be explained.},
  author       = {Hemminki, Kari and Försti, Asta and Fallah, Mahdi and Sundquist, Jan and Sundquist, Kristina and Ji, Jianguang},
  issn         = {0020-7136},
  language     = {eng},
  number       = {10},
  pages        = {2397--2403},
  publisher    = {John Wiley & Sons},
  series       = {International Journal of Cancer},
  title        = {Risk of cancer in patients with medically diagnosed hay fever or allergic rhinitis.},
  url          = {http://dx.doi.org/10.1002/ijc.28873},
  volume       = {135},
  year         = {2014},
}