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Association between high dietary intake of the n-3 polyunsaturated fatty acid docosahexaenoic acid and reduced risk of Crohn's disease

Chan, S. S. M.; Luben, R.; Olsen, A.; Tjonneland, A.; Kaaks, R.; Lindgren, Stefan LU ; Grip, Olof LU ; Bergmann, M. M.; Boeing, H. and Hallmans, G., et al. (2014) In Alimentary Pharmacology & Therapeutics 39(8). p.834-842
Abstract
Background There are plausible mechanisms for how dietary docosahexaenoic acid (DHA), an n-3 polyunsaturated fatty acid, could prevent Crohn's disease (CD). Aim To conduct a prospective study to investigate the association between increased intake of DHA and risk of CD. Methods Overall, 229702 participants were recruited from nine European centres between 1991 and 1998. At recruitment, dietary intakes of DHA and fatty acids were measured using validated food frequency questionnaires. The cohort was monitored through to June 2004 to identify participants who developed incident CD. In a nested case-control analysis, each case was matched with four controls; odds ratios (ORs) were calculated for quintiles of DHA intake, adjusted for total... (More)
Background There are plausible mechanisms for how dietary docosahexaenoic acid (DHA), an n-3 polyunsaturated fatty acid, could prevent Crohn's disease (CD). Aim To conduct a prospective study to investigate the association between increased intake of DHA and risk of CD. Methods Overall, 229702 participants were recruited from nine European centres between 1991 and 1998. At recruitment, dietary intakes of DHA and fatty acids were measured using validated food frequency questionnaires. The cohort was monitored through to June 2004 to identify participants who developed incident CD. In a nested case-control analysis, each case was matched with four controls; odds ratios (ORs) were calculated for quintiles of DHA intake, adjusted for total energy intake, smoking, other dietary fatty acids, dietary vitamin D and body mass index. Results Seventy-three participants developed incident CD. All higher quintiles of DHA intake were inversely associated with development of CD; the highest quintile had the greatest effect size (OR=0.07; 95% CI=0.02-0.81). The OR trend across quintiles of DHA was 0.54 (95% CI=0.30-0.99, P-trend=0.04). Including BMI in the multivariate analysis, due to its correlation with dietary fat showed similar associations. There were no associations with the other dietary fatty acids studied. Conclusion There were inverse associations, with a biological gradient between increasing dietary docosahexaenoic acid intakes and incident Crohn's disease. Further studies in other populations should measure docosahexaenoic acid to determine if the association is consistent and the hypothesis tested in randomised controlled trials of purely docosahexaenoic acid supplementation. (Less)
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publication status
published
subject
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Alimentary Pharmacology & Therapeutics
volume
39
issue
8
pages
834 - 842
publisher
Wiley-Blackwell
external identifiers
  • wos:000332796200009
  • scopus:84896395415
ISSN
0269-2813
DOI
10.1111/apt.12670
language
English
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yes
id
d654a6a5-cec8-4cfd-aff5-3485b7f62b71 (old id 4439573)
date added to LUP
2014-07-01 07:44:18
date last changed
2017-11-05 03:53:25
@article{d654a6a5-cec8-4cfd-aff5-3485b7f62b71,
  abstract     = {Background There are plausible mechanisms for how dietary docosahexaenoic acid (DHA), an n-3 polyunsaturated fatty acid, could prevent Crohn's disease (CD). Aim To conduct a prospective study to investigate the association between increased intake of DHA and risk of CD. Methods Overall, 229702 participants were recruited from nine European centres between 1991 and 1998. At recruitment, dietary intakes of DHA and fatty acids were measured using validated food frequency questionnaires. The cohort was monitored through to June 2004 to identify participants who developed incident CD. In a nested case-control analysis, each case was matched with four controls; odds ratios (ORs) were calculated for quintiles of DHA intake, adjusted for total energy intake, smoking, other dietary fatty acids, dietary vitamin D and body mass index. Results Seventy-three participants developed incident CD. All higher quintiles of DHA intake were inversely associated with development of CD; the highest quintile had the greatest effect size (OR=0.07; 95% CI=0.02-0.81). The OR trend across quintiles of DHA was 0.54 (95% CI=0.30-0.99, P-trend=0.04). Including BMI in the multivariate analysis, due to its correlation with dietary fat showed similar associations. There were no associations with the other dietary fatty acids studied. Conclusion There were inverse associations, with a biological gradient between increasing dietary docosahexaenoic acid intakes and incident Crohn's disease. Further studies in other populations should measure docosahexaenoic acid to determine if the association is consistent and the hypothesis tested in randomised controlled trials of purely docosahexaenoic acid supplementation.},
  author       = {Chan, S. S. M. and Luben, R. and Olsen, A. and Tjonneland, A. and Kaaks, R. and Lindgren, Stefan and Grip, Olof and Bergmann, M. M. and Boeing, H. and Hallmans, G. and Karling, P. and Overvad, K. and Veno, S. K. and van Schaik, F. and Bueno-de-Mesquita, B. and Oldenburg, B. and Khaw, K. -T. and Riboli, E. and Hart, A. R.},
  issn         = {0269-2813},
  language     = {eng},
  number       = {8},
  pages        = {834--842},
  publisher    = {Wiley-Blackwell},
  series       = {Alimentary Pharmacology & Therapeutics},
  title        = {Association between high dietary intake of the n-3 polyunsaturated fatty acid docosahexaenoic acid and reduced risk of Crohn's disease},
  url          = {http://dx.doi.org/10.1111/apt.12670},
  volume       = {39},
  year         = {2014},
}