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Association of nuclear-localized nemo-like kinase with heat-shock protein 27 inhibits apoptosis in human breast cancer cells.

Hallgren, Gina LU ; Masoumi, Katarzyna LU ; Zarrizi, Reihaneh LU ; Hellman, Ulf ; Karlsson, Per ; Helou, Khalil and Massoumi, Ramin LU (2014) In PLoS ONE 9(5).
Abstract
Nemo-like kinase (NLK), a proline-directed serine/threonine kinase regulated by phosphorylation, can be localized in the cytosol or in the nucleus. Whether the localization of NLK can affect cell survival or cell apoptosis is yet to be disclosed. In the present study we found that NLK was mainly localized in the nuclei of breast cancer cells, in contrast to a cytosolic localization in non-cancerous breast epithelial cells. The nuclear localization of NLK was mediated through direct interaction with Heat shock protein 27 (HSP27) which further protected cancer cells from apoptosis. The present study provides evidence of a novel mechanism by which HSP27 recognizes NLK in the breast cancer cells and prevents NLK-mediated cell apoptosis.
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author
; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
PLoS ONE
volume
9
issue
5
article number
e96506
publisher
Public Library of Science (PLoS)
external identifiers
  • pmid:24816797
  • wos:000336838000040
  • scopus:84901244666
  • pmid:24816797
ISSN
1932-6203
DOI
10.1371/journal.pone.0096506
language
English
LU publication?
yes
additional info
The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Division of Translational Cancer Research (013250500), Molecular Tumor Pathology (013017570)
id
f19f71e7-d2c9-49ad-8c4a-f1c189504875 (old id 4455381)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/24816797?dopt=Abstract
date added to LUP
2016-04-01 12:55:12
date last changed
2021-09-15 02:53:20
@article{f19f71e7-d2c9-49ad-8c4a-f1c189504875,
  abstract     = {Nemo-like kinase (NLK), a proline-directed serine/threonine kinase regulated by phosphorylation, can be localized in the cytosol or in the nucleus. Whether the localization of NLK can affect cell survival or cell apoptosis is yet to be disclosed. In the present study we found that NLK was mainly localized in the nuclei of breast cancer cells, in contrast to a cytosolic localization in non-cancerous breast epithelial cells. The nuclear localization of NLK was mediated through direct interaction with Heat shock protein 27 (HSP27) which further protected cancer cells from apoptosis. The present study provides evidence of a novel mechanism by which HSP27 recognizes NLK in the breast cancer cells and prevents NLK-mediated cell apoptosis.},
  author       = {Hallgren, Gina and Masoumi, Katarzyna and Zarrizi, Reihaneh and Hellman, Ulf and Karlsson, Per and Helou, Khalil and Massoumi, Ramin},
  issn         = {1932-6203},
  language     = {eng},
  number       = {5},
  publisher    = {Public Library of Science (PLoS)},
  series       = {PLoS ONE},
  title        = {Association of nuclear-localized nemo-like kinase with heat-shock protein 27 inhibits apoptosis in human breast cancer cells.},
  url          = {https://lup.lub.lu.se/search/files/3045833/4936668.pdf},
  doi          = {10.1371/journal.pone.0096506},
  volume       = {9},
  year         = {2014},
}