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Association of nuclear-localized nemo-like kinase with heat-shock protein 27 inhibits apoptosis in human breast cancer cells.

Hallgren, Gina LU ; Masoumi, Katarzyna LU ; Zarrizi, Reihaneh LU ; Hellman, Ulf; Karlsson, Per; Helou, Khalil and Massoumi, Ramin LU (2014) In PLoS ONE 9(5).
Abstract
Nemo-like kinase (NLK), a proline-directed serine/threonine kinase regulated by phosphorylation, can be localized in the cytosol or in the nucleus. Whether the localization of NLK can affect cell survival or cell apoptosis is yet to be disclosed. In the present study we found that NLK was mainly localized in the nuclei of breast cancer cells, in contrast to a cytosolic localization in non-cancerous breast epithelial cells. The nuclear localization of NLK was mediated through direct interaction with Heat shock protein 27 (HSP27) which further protected cancer cells from apoptosis. The present study provides evidence of a novel mechanism by which HSP27 recognizes NLK in the breast cancer cells and prevents NLK-mediated cell apoptosis.
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
PLoS ONE
volume
9
issue
5
publisher
Public Library of Science
external identifiers
  • pmid:24816797
  • wos:000336838000040
  • scopus:84901244666
ISSN
1932-6203
DOI
10.1371/journal.pone.0096506
language
English
LU publication?
yes
id
f19f71e7-d2c9-49ad-8c4a-f1c189504875 (old id 4455381)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/24816797?dopt=Abstract
date added to LUP
2014-06-03 23:05:21
date last changed
2017-03-05 03:41:43
@article{f19f71e7-d2c9-49ad-8c4a-f1c189504875,
  abstract     = {Nemo-like kinase (NLK), a proline-directed serine/threonine kinase regulated by phosphorylation, can be localized in the cytosol or in the nucleus. Whether the localization of NLK can affect cell survival or cell apoptosis is yet to be disclosed. In the present study we found that NLK was mainly localized in the nuclei of breast cancer cells, in contrast to a cytosolic localization in non-cancerous breast epithelial cells. The nuclear localization of NLK was mediated through direct interaction with Heat shock protein 27 (HSP27) which further protected cancer cells from apoptosis. The present study provides evidence of a novel mechanism by which HSP27 recognizes NLK in the breast cancer cells and prevents NLK-mediated cell apoptosis.},
  articleno    = {e96506},
  author       = {Hallgren, Gina and Masoumi, Katarzyna and Zarrizi, Reihaneh and Hellman, Ulf and Karlsson, Per and Helou, Khalil and Massoumi, Ramin},
  issn         = {1932-6203},
  language     = {eng},
  number       = {5},
  publisher    = {Public Library of Science},
  series       = {PLoS ONE},
  title        = {Association of nuclear-localized nemo-like kinase with heat-shock protein 27 inhibits apoptosis in human breast cancer cells.},
  url          = {http://dx.doi.org/10.1371/journal.pone.0096506},
  volume       = {9},
  year         = {2014},
}