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Metformin induces lactate production in peripheral blood mononuclear cells and platelets through specific mitochondrial complex I inhibition.

Piel, Sarah LU ; Ehinger, Johannes LU ; Elmer, Eskil LU and Hansson, Magnus LU (2015) In Acta Physiologica 213(1). p.171-180
Abstract
Metformin is a widely used antidiabetic drug associated with the rare side effect of lactic acidosis which has been proposed to be linked to drug-induced mitochondrial dysfunction. Using respirometry, the aim of this study was to evaluate mitochondrial toxicity of metformin to human blood cells in relation to that of phenformin, a biguanide analogue withdrawn in most countries due to a high incidence of lactic acidosis.
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Acta Physiologica
volume
213
issue
1
pages
171 - 180
publisher
Wiley-Blackwell
external identifiers
  • pmid:24801139
  • wos:000346475000012
  • scopus:84940845680
ISSN
1748-1708
DOI
10.1111/apha.12311
language
English
LU publication?
yes
id
c6f1f9fb-b61b-4cf3-b525-b6ab405663a7 (old id 4455749)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/24801139?dopt=Abstract
date added to LUP
2014-06-03 20:38:30
date last changed
2017-09-03 03:15:09
@article{c6f1f9fb-b61b-4cf3-b525-b6ab405663a7,
  abstract     = {Metformin is a widely used antidiabetic drug associated with the rare side effect of lactic acidosis which has been proposed to be linked to drug-induced mitochondrial dysfunction. Using respirometry, the aim of this study was to evaluate mitochondrial toxicity of metformin to human blood cells in relation to that of phenformin, a biguanide analogue withdrawn in most countries due to a high incidence of lactic acidosis.},
  author       = {Piel, Sarah and Ehinger, Johannes and Elmer, Eskil and Hansson, Magnus},
  issn         = {1748-1708},
  language     = {eng},
  number       = {1},
  pages        = {171--180},
  publisher    = {Wiley-Blackwell},
  series       = {Acta Physiologica},
  title        = {Metformin induces lactate production in peripheral blood mononuclear cells and platelets through specific mitochondrial complex I inhibition.},
  url          = {http://dx.doi.org/10.1111/apha.12311},
  volume       = {213},
  year         = {2015},
}