Skip to main content

Lund University Publications

LUND UNIVERSITY LIBRARIES

Increased survival among HIV-1 and HIV-2 dual-infected individuals compared to HIV-1 single-infected individuals

Esbjörnsson, Joakim LU orcid ; Månsson, Fredrik LU ; Kvist, Anders LU orcid ; Isberg, Per-Erik LU ; Biague, Antonio J. ; da Silva, Zacarias J. ; Jansson, Marianne LU ; Fenyö, Eva Maria LU ; Norrgren, Hans LU and Medstrand, Patrik LU orcid (2014) In AIDS 28(7). p.949-957
Abstract
Objective: To compare survival times of HIV-1 single and HIV-1 and HIV-2 dual-infected individuals. Design: Prospective open cohort study. Methods: We analysed data from 259 HIV-1-seroincident cases (either HIV-1 single or HIV-1 and HIV-2 dual-infected) from a cohort with long follow-up (similar to 20 years) in order to study the influence of type of infection and infection order on mortality. Sex and age at HIV-1 infection date was controlled for in a Cox proportional-hazards model. Results: Dual-infected individuals had a 42% longer time from HIV-1 infection to death compared with single-infected individuals, adjusting for age asymmetries between groups. Dual-infected individuals with an HIV-2 infection preceding the HIV-1 infection had... (More)
Objective: To compare survival times of HIV-1 single and HIV-1 and HIV-2 dual-infected individuals. Design: Prospective open cohort study. Methods: We analysed data from 259 HIV-1-seroincident cases (either HIV-1 single or HIV-1 and HIV-2 dual-infected) from a cohort with long follow-up (similar to 20 years) in order to study the influence of type of infection and infection order on mortality. Sex and age at HIV-1 infection date was controlled for in a Cox proportional-hazards model. Results: Dual-infected individuals had a 42% longer time from HIV-1 infection to death compared with single-infected individuals, adjusting for age asymmetries between groups. Dual-infected individuals with an HIV-2 infection preceding the HIV-1 infection had a more than two-fold lower mortality risk during follow-up than HIV-1 single-infected individuals. Conclusion: Survival time is longer and the risk of progression to death is lower among HIV-1 and HIV-2 dual-infected individuals compared to HIV-1 single-infected individuals. This natural inhibition could have implications for the development of future HIV-1 vaccines and therapeutics. (Less)
Please use this url to cite or link to this publication:
author
; ; ; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
dual infection, HIV-2, mortality, HIV-1, survival
in
AIDS
volume
28
issue
7
pages
949 - 957
publisher
Lippincott Williams & Wilkins
external identifiers
  • wos:000335350900003
  • scopus:84897491606
  • pmid:24361623
ISSN
1473-5571
DOI
10.1097/QAD.0000000000000101
language
English
LU publication?
yes
additional info
The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Division of Infection Medicine (SUS) (013008000), Division of Medical Microbiology (013250400), Department of Statistics (012014000), Oncology, MV (013035000), Infectious Diseases Research Unit (013242010), Clinical Virology, Malmö (013017580)
id
3842a644-5e30-45d0-b5bf-13431f1cb675 (old id 4479340)
date added to LUP
2016-04-01 10:44:53
date last changed
2024-10-07 12:31:00
@article{3842a644-5e30-45d0-b5bf-13431f1cb675,
  abstract     = {{Objective: To compare survival times of HIV-1 single and HIV-1 and HIV-2 dual-infected individuals. Design: Prospective open cohort study. Methods: We analysed data from 259 HIV-1-seroincident cases (either HIV-1 single or HIV-1 and HIV-2 dual-infected) from a cohort with long follow-up (similar to 20 years) in order to study the influence of type of infection and infection order on mortality. Sex and age at HIV-1 infection date was controlled for in a Cox proportional-hazards model. Results: Dual-infected individuals had a 42% longer time from HIV-1 infection to death compared with single-infected individuals, adjusting for age asymmetries between groups. Dual-infected individuals with an HIV-2 infection preceding the HIV-1 infection had a more than two-fold lower mortality risk during follow-up than HIV-1 single-infected individuals. Conclusion: Survival time is longer and the risk of progression to death is lower among HIV-1 and HIV-2 dual-infected individuals compared to HIV-1 single-infected individuals. This natural inhibition could have implications for the development of future HIV-1 vaccines and therapeutics.}},
  author       = {{Esbjörnsson, Joakim and Månsson, Fredrik and Kvist, Anders and Isberg, Per-Erik and Biague, Antonio J. and da Silva, Zacarias J. and Jansson, Marianne and Fenyö, Eva Maria and Norrgren, Hans and Medstrand, Patrik}},
  issn         = {{1473-5571}},
  keywords     = {{dual infection; HIV-2; mortality; HIV-1; survival}},
  language     = {{eng}},
  number       = {{7}},
  pages        = {{949--957}},
  publisher    = {{Lippincott Williams & Wilkins}},
  series       = {{AIDS}},
  title        = {{Increased survival among HIV-1 and HIV-2 dual-infected individuals compared to HIV-1 single-infected individuals}},
  url          = {{http://dx.doi.org/10.1097/QAD.0000000000000101}},
  doi          = {{10.1097/QAD.0000000000000101}},
  volume       = {{28}},
  year         = {{2014}},
}