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Increased survival among HIV-1 and HIV-2 dual-infected individuals compared to HIV-1 single-infected individuals

Esbjörnsson, Joakim LU ; Månsson, Fredrik LU ; Kvist, Anders LU ; Isberg, Per-Erik LU ; Biague, Antonio J.; da Silva, Zacarias J.; Jansson, Marianne LU ; Fenyö, Eva Maria LU ; Norrgren, Hans LU and Medstrand, Patrik LU (2014) In AIDS 28(7). p.949-957
Abstract
Objective: To compare survival times of HIV-1 single and HIV-1 and HIV-2 dual-infected individuals. Design: Prospective open cohort study. Methods: We analysed data from 259 HIV-1-seroincident cases (either HIV-1 single or HIV-1 and HIV-2 dual-infected) from a cohort with long follow-up (similar to 20 years) in order to study the influence of type of infection and infection order on mortality. Sex and age at HIV-1 infection date was controlled for in a Cox proportional-hazards model. Results: Dual-infected individuals had a 42% longer time from HIV-1 infection to death compared with single-infected individuals, adjusting for age asymmetries between groups. Dual-infected individuals with an HIV-2 infection preceding the HIV-1 infection had... (More)
Objective: To compare survival times of HIV-1 single and HIV-1 and HIV-2 dual-infected individuals. Design: Prospective open cohort study. Methods: We analysed data from 259 HIV-1-seroincident cases (either HIV-1 single or HIV-1 and HIV-2 dual-infected) from a cohort with long follow-up (similar to 20 years) in order to study the influence of type of infection and infection order on mortality. Sex and age at HIV-1 infection date was controlled for in a Cox proportional-hazards model. Results: Dual-infected individuals had a 42% longer time from HIV-1 infection to death compared with single-infected individuals, adjusting for age asymmetries between groups. Dual-infected individuals with an HIV-2 infection preceding the HIV-1 infection had a more than two-fold lower mortality risk during follow-up than HIV-1 single-infected individuals. Conclusion: Survival time is longer and the risk of progression to death is lower among HIV-1 and HIV-2 dual-infected individuals compared to HIV-1 single-infected individuals. This natural inhibition could have implications for the development of future HIV-1 vaccines and therapeutics. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
dual infection, HIV-2, mortality, HIV-1, survival
in
AIDS
volume
28
issue
7
pages
949 - 957
publisher
Lippincott Williams & Wilkins
external identifiers
  • wos:000335350900003
  • scopus:84897491606
ISSN
1473-5571
DOI
10.1097/QAD.0000000000000101
language
English
LU publication?
yes
id
3842a644-5e30-45d0-b5bf-13431f1cb675 (old id 4479340)
date added to LUP
2014-06-19 14:57:13
date last changed
2017-01-01 03:51:51
@article{3842a644-5e30-45d0-b5bf-13431f1cb675,
  abstract     = {Objective: To compare survival times of HIV-1 single and HIV-1 and HIV-2 dual-infected individuals. Design: Prospective open cohort study. Methods: We analysed data from 259 HIV-1-seroincident cases (either HIV-1 single or HIV-1 and HIV-2 dual-infected) from a cohort with long follow-up (similar to 20 years) in order to study the influence of type of infection and infection order on mortality. Sex and age at HIV-1 infection date was controlled for in a Cox proportional-hazards model. Results: Dual-infected individuals had a 42% longer time from HIV-1 infection to death compared with single-infected individuals, adjusting for age asymmetries between groups. Dual-infected individuals with an HIV-2 infection preceding the HIV-1 infection had a more than two-fold lower mortality risk during follow-up than HIV-1 single-infected individuals. Conclusion: Survival time is longer and the risk of progression to death is lower among HIV-1 and HIV-2 dual-infected individuals compared to HIV-1 single-infected individuals. This natural inhibition could have implications for the development of future HIV-1 vaccines and therapeutics.},
  author       = {Esbjörnsson, Joakim and Månsson, Fredrik and Kvist, Anders and Isberg, Per-Erik and Biague, Antonio J. and da Silva, Zacarias J. and Jansson, Marianne and Fenyö, Eva Maria and Norrgren, Hans and Medstrand, Patrik},
  issn         = {1473-5571},
  keyword      = {dual infection,HIV-2,mortality,HIV-1,survival},
  language     = {eng},
  number       = {7},
  pages        = {949--957},
  publisher    = {Lippincott Williams & Wilkins},
  series       = {AIDS},
  title        = {Increased survival among HIV-1 and HIV-2 dual-infected individuals compared to HIV-1 single-infected individuals},
  url          = {http://dx.doi.org/10.1097/QAD.0000000000000101},
  volume       = {28},
  year         = {2014},
}