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Familial Risks for Liver, Gallbladder and Bile Duct Cancers and for Their Risk Factors in Sweden, a Low-Incidence Country

Hemminki, Kari LU ; Sundquist, Kristina LU ; Sundquist, Jan LU ; Försti, Asta LU ; Liska, Vaclav ; Hemminki, Akseli and Li, Xinjun LU (2022) In Cancers 14(8).
Abstract

We used the Swedish Cancer Registry data to address familial risks for concordant (same) and discordant (different) hepatobiliary cancers, including their associations with any other cancers and with known risk factors. Risks were also assessed between spouses. The analysis covered Swedish families and their cancers between years 1958 and 2018. Adjusted familial risks were expressed as standardized incidence ratios (SIRs). Familial SIRs for concordant hepatocellular carcinoma (HCC) were 2.60, and for gallbladder cancer they were at the same level (2.76). Familial risk was also found for intrahepatic bile duct cancer and for female extrahepatic bile duct cancer. HCC was associated with lung and cervical cancers; extrahepatic bile duct... (More)

We used the Swedish Cancer Registry data to address familial risks for concordant (same) and discordant (different) hepatobiliary cancers, including their associations with any other cancers and with known risk factors. Risks were also assessed between spouses. The analysis covered Swedish families and their cancers between years 1958 and 2018. Adjusted familial risks were expressed as standardized incidence ratios (SIRs). Familial SIRs for concordant hepatocellular carcinoma (HCC) were 2.60, and for gallbladder cancer they were at the same level (2.76). Familial risk was also found for intrahepatic bile duct cancer and for female extrahepatic bile duct cancer. HCC was associated with lung and cervical cancers; extrahepatic bile duct and ampullary cancers were associated with colon and pancreatic cancers, suggesting Lynch syndrome. Among spouses, hepatobiliary cancer was associated with HCC, stomach, pancreatic, cervical and upper aerodigestive tract cancers. Among risk factors, family members diagnosed with alcohol-related disease showed association with HCC. The observed familial risks for hepatobiliary cancers were relatively high, and considering the poor prognosis of these cancers, prevention is of the utmost importance and should focus on moderation of alcohol consumption, vaccination/treatment of hepatitis viral infections and avoidance of overweight and other risk factors of type 2 diabetes.

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author
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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
alcohol, discordant familial risks, gallbladder cancer, hepatocellular carcinoma, risk factors, spouse correlation
in
Cancers
volume
14
issue
8
article number
1938
publisher
MDPI AG
external identifiers
  • pmid:35454845
  • scopus:85127978845
ISSN
2072-6694
DOI
10.3390/cancers14081938
language
English
LU publication?
yes
id
44ce6493-544d-496f-a456-6d21a1c0fa21
date added to LUP
2022-06-09 11:26:11
date last changed
2024-04-18 10:39:05
@article{44ce6493-544d-496f-a456-6d21a1c0fa21,
  abstract     = {{<p>We used the Swedish Cancer Registry data to address familial risks for concordant (same) and discordant (different) hepatobiliary cancers, including their associations with any other cancers and with known risk factors. Risks were also assessed between spouses. The analysis covered Swedish families and their cancers between years 1958 and 2018. Adjusted familial risks were expressed as standardized incidence ratios (SIRs). Familial SIRs for concordant hepatocellular carcinoma (HCC) were 2.60, and for gallbladder cancer they were at the same level (2.76). Familial risk was also found for intrahepatic bile duct cancer and for female extrahepatic bile duct cancer. HCC was associated with lung and cervical cancers; extrahepatic bile duct and ampullary cancers were associated with colon and pancreatic cancers, suggesting Lynch syndrome. Among spouses, hepatobiliary cancer was associated with HCC, stomach, pancreatic, cervical and upper aerodigestive tract cancers. Among risk factors, family members diagnosed with alcohol-related disease showed association with HCC. The observed familial risks for hepatobiliary cancers were relatively high, and considering the poor prognosis of these cancers, prevention is of the utmost importance and should focus on moderation of alcohol consumption, vaccination/treatment of hepatitis viral infections and avoidance of overweight and other risk factors of type 2 diabetes.</p>}},
  author       = {{Hemminki, Kari and Sundquist, Kristina and Sundquist, Jan and Försti, Asta and Liska, Vaclav and Hemminki, Akseli and Li, Xinjun}},
  issn         = {{2072-6694}},
  keywords     = {{alcohol; discordant familial risks; gallbladder cancer; hepatocellular carcinoma; risk factors; spouse correlation}},
  language     = {{eng}},
  month        = {{04}},
  number       = {{8}},
  publisher    = {{MDPI AG}},
  series       = {{Cancers}},
  title        = {{Familial Risks for Liver, Gallbladder and Bile Duct Cancers and for Their Risk Factors in Sweden, a Low-Incidence Country}},
  url          = {{http://dx.doi.org/10.3390/cancers14081938}},
  doi          = {{10.3390/cancers14081938}},
  volume       = {{14}},
  year         = {{2022}},
}