Advanced

Effects of palmitate on genome-wide mRNA expression and DNA methylation patterns in human pancreatic islets.

Hall, Elin LU ; Volkov, Petr LU ; Dayeh, Tasnim LU ; Bacos, Karl LU ; Rönn, Tina LU ; Dekker Nitert, Marloes LU and Ling, Charlotte LU (2014) In BMC Medicine 12(1).
Abstract
Circulating free fatty acids are often elevated in patients with type 2 diabetes (T2D) and obese individuals. Chronic exposure to high levels of saturated fatty acids has detrimental effects on islet function and insulin secretion. Altered gene expression and epigenetics may contribute to T2D and obesity. However, there is limited information on whether fatty acids alter the genome-wide transcriptome profile in conjunction with DNA methylation patterns in human pancreatic islets. To dissect the molecular mechanisms linking lipotoxicity to impaired insulin secretion, we investigated the effects of a 48 h palmitate treatment in vitro on genome-wide mRNA expression and DNA methylation patterns in human pancreatic islets.
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
BMC Medicine
volume
12
issue
1
publisher
BioMed Central
external identifiers
  • pmid:24953961
  • wos:000338252100001
  • scopus:84902987423
ISSN
1741-7015
DOI
10.1186/1741-7015-12-103
language
English
LU publication?
yes
id
0f9ff8c4-1a21-4b97-aaab-1935001d62e6 (old id 4527097)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/24953961?dopt=Abstract
date added to LUP
2014-07-06 20:51:12
date last changed
2017-10-08 03:55:40
@article{0f9ff8c4-1a21-4b97-aaab-1935001d62e6,
  abstract     = {Circulating free fatty acids are often elevated in patients with type 2 diabetes (T2D) and obese individuals. Chronic exposure to high levels of saturated fatty acids has detrimental effects on islet function and insulin secretion. Altered gene expression and epigenetics may contribute to T2D and obesity. However, there is limited information on whether fatty acids alter the genome-wide transcriptome profile in conjunction with DNA methylation patterns in human pancreatic islets. To dissect the molecular mechanisms linking lipotoxicity to impaired insulin secretion, we investigated the effects of a 48 h palmitate treatment in vitro on genome-wide mRNA expression and DNA methylation patterns in human pancreatic islets.},
  articleno    = {103},
  author       = {Hall, Elin and Volkov, Petr and Dayeh, Tasnim and Bacos, Karl and Rönn, Tina and Dekker Nitert, Marloes and Ling, Charlotte},
  issn         = {1741-7015},
  language     = {eng},
  number       = {1},
  publisher    = {BioMed Central},
  series       = {BMC Medicine},
  title        = {Effects of palmitate on genome-wide mRNA expression and DNA methylation patterns in human pancreatic islets.},
  url          = {http://dx.doi.org/10.1186/1741-7015-12-103},
  volume       = {12},
  year         = {2014},
}