Advanced

Functional Effects of Toll-Like Receptor (TLR)3, 7, 9, RIG-I and MDA-5 Stimulation in Nasal Epithelial Cells.

Tengroth, Lotta; Millrud, Camilla Rydberg; Kvarnhammar, Anne Månsson; Kumlien Georén, Susanna; Latif, Leith LU and Cardell, Lars-Olaf LU (2014) In PLoS ONE 9(6).
Abstract
The human nasal epithelium is an important physical barrier, and a part of the innate immune defense that protect against pathogens. The epithelial cells recognize microbial components by pattern-recognition receptors (PRRs), and thereby trigger an immune response. Even though TLR3, TLR7, TLR9, RIG-I and MDA-5 are all known to respond to viral stimulation, their potential role in chronic airway inflammation triggered by local cytokine release remains to be established.
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
PLoS ONE
volume
9
issue
6
publisher
Public Library of Science
external identifiers
  • pmid:24886842
  • wos:000336956300050
  • scopus:84902331442
ISSN
1932-6203
DOI
10.1371/journal.pone.0098239
language
English
LU publication?
yes
id
779e0947-9358-4602-b968-306f7822f6c2 (old id 4529429)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/24886842?dopt=Abstract
date added to LUP
2014-07-04 12:36:33
date last changed
2017-11-12 03:43:21
@article{779e0947-9358-4602-b968-306f7822f6c2,
  abstract     = {The human nasal epithelium is an important physical barrier, and a part of the innate immune defense that protect against pathogens. The epithelial cells recognize microbial components by pattern-recognition receptors (PRRs), and thereby trigger an immune response. Even though TLR3, TLR7, TLR9, RIG-I and MDA-5 are all known to respond to viral stimulation, their potential role in chronic airway inflammation triggered by local cytokine release remains to be established.},
  articleno    = {e98239},
  author       = {Tengroth, Lotta and Millrud, Camilla Rydberg and Kvarnhammar, Anne Månsson and Kumlien Georén, Susanna and Latif, Leith and Cardell, Lars-Olaf},
  issn         = {1932-6203},
  language     = {eng},
  number       = {6},
  publisher    = {Public Library of Science},
  series       = {PLoS ONE},
  title        = {Functional Effects of Toll-Like Receptor (TLR)3, 7, 9, RIG-I and MDA-5 Stimulation in Nasal Epithelial Cells.},
  url          = {http://dx.doi.org/10.1371/journal.pone.0098239},
  volume       = {9},
  year         = {2014},
}