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Effects of a healthy Nordic diet on plasma 25-hydroxyvitamin D concentration in subjects with metabolic syndrome: a randomized, placebo-controlled trial (SYSDIET)

Brader, Lea; Rejnmark, Lars; Carlberg, Carsten; Schwab, Ursula; Kolehmainen, Marjukka; Rosqvist, Fredrik; Cloetens, Lieselotte LU ; Landin-Olsson, Mona LU ; Gunnarsdottir, Ingibjorg and Poutanen, Kaisa S., et al. (2014) In European Journal of Nutrition 53(4). p.1123-1134
Abstract
At northern latitudes, vitamin D is not synthesized endogenously during winter, causing low plasma 25-hydroxyvitamin D (25(OH)D) concentrations. Therefore, we evaluated the effects of a healthy Nordic diet based on Nordic nutrition recommendations (NNR) on plasma 25(OH)D and explored its dietary predictors. In a Nordic multi-centre trial, subjects (n = 213) with metabolic syndrome were randomized to a control or a healthy Nordic diet favouring fish (a parts per thousand yen300 g/week, including a parts per thousand yen200 g/week fatty fish), whole-grain products, berries, fruits, vegetables, rapeseed oil and low-fat dairy products. Plasma 25(OH)D and parathyroid hormone were analysed before and after 18- to 24-week intervention. At... (More)
At northern latitudes, vitamin D is not synthesized endogenously during winter, causing low plasma 25-hydroxyvitamin D (25(OH)D) concentrations. Therefore, we evaluated the effects of a healthy Nordic diet based on Nordic nutrition recommendations (NNR) on plasma 25(OH)D and explored its dietary predictors. In a Nordic multi-centre trial, subjects (n = 213) with metabolic syndrome were randomized to a control or a healthy Nordic diet favouring fish (a parts per thousand yen300 g/week, including a parts per thousand yen200 g/week fatty fish), whole-grain products, berries, fruits, vegetables, rapeseed oil and low-fat dairy products. Plasma 25(OH)D and parathyroid hormone were analysed before and after 18- to 24-week intervention. At baseline, 45 % had vitamin D inadequacy (< 50 nmol/l), whereas 8 % had deficiency (< 25 nmol/l). Dietary vitamin D intake was increased by the healthy Nordic diet (P < 0.001). The healthy Nordic and the control diet reduced the prevalence of vitamin D inadequacy by 42 % (P < 0.001) and 19 % (P = 0.002), respectively, without between-group difference (P = 0.142). Compared with control, plasma 25(OH)D (P = 0.208) and parathyroid hormone (P = 0.207) were not altered by the healthy Nordic diet. Predictors for 25(OH)D were intake of vitamin D, eicosapentaenoic acids (EPA), docosahexaenoic acids (DHA), vitamin D supplement, plasma EPA and plasma DHA. Nevertheless, only vitamin D intake and season predicted the 25(OH)D changes. Consuming a healthy Nordic diet based on NNR increased vitamin D intake but not plasma 25(OH)D concentration. The reason why fish consumption did not improve vitamin D status might be that many fish are farmed and might contain little vitamin D or that frying fish may result in vitamin D extraction. Additional ways to improve vitamin D status in Nordic countries may be needed. (Less)
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keywords
Vitamin D, 25-hydroxyvitamin D, Healthy Nordic diet, Nordic nutrition, recommendations, Metabolic syndrome
in
European Journal of Nutrition
volume
53
issue
4
pages
1123 - 1134
publisher
Springer
external identifiers
  • wos:000336801700012
  • scopus:84903448252
ISSN
1436-6215
DOI
10.1007/s00394-014-0674-3
language
English
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yes
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2d079190-3229-4202-b4da-07c241b4f06d (old id 4552435)
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2014-08-01 07:38:23
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2017-07-02 03:02:09
@article{2d079190-3229-4202-b4da-07c241b4f06d,
  abstract     = {At northern latitudes, vitamin D is not synthesized endogenously during winter, causing low plasma 25-hydroxyvitamin D (25(OH)D) concentrations. Therefore, we evaluated the effects of a healthy Nordic diet based on Nordic nutrition recommendations (NNR) on plasma 25(OH)D and explored its dietary predictors. In a Nordic multi-centre trial, subjects (n = 213) with metabolic syndrome were randomized to a control or a healthy Nordic diet favouring fish (a parts per thousand yen300 g/week, including a parts per thousand yen200 g/week fatty fish), whole-grain products, berries, fruits, vegetables, rapeseed oil and low-fat dairy products. Plasma 25(OH)D and parathyroid hormone were analysed before and after 18- to 24-week intervention. At baseline, 45 % had vitamin D inadequacy (&lt; 50 nmol/l), whereas 8 % had deficiency (&lt; 25 nmol/l). Dietary vitamin D intake was increased by the healthy Nordic diet (P &lt; 0.001). The healthy Nordic and the control diet reduced the prevalence of vitamin D inadequacy by 42 % (P &lt; 0.001) and 19 % (P = 0.002), respectively, without between-group difference (P = 0.142). Compared with control, plasma 25(OH)D (P = 0.208) and parathyroid hormone (P = 0.207) were not altered by the healthy Nordic diet. Predictors for 25(OH)D were intake of vitamin D, eicosapentaenoic acids (EPA), docosahexaenoic acids (DHA), vitamin D supplement, plasma EPA and plasma DHA. Nevertheless, only vitamin D intake and season predicted the 25(OH)D changes. Consuming a healthy Nordic diet based on NNR increased vitamin D intake but not plasma 25(OH)D concentration. The reason why fish consumption did not improve vitamin D status might be that many fish are farmed and might contain little vitamin D or that frying fish may result in vitamin D extraction. Additional ways to improve vitamin D status in Nordic countries may be needed.},
  author       = {Brader, Lea and Rejnmark, Lars and Carlberg, Carsten and Schwab, Ursula and Kolehmainen, Marjukka and Rosqvist, Fredrik and Cloetens, Lieselotte and Landin-Olsson, Mona and Gunnarsdottir, Ingibjorg and Poutanen, Kaisa S. and Herzig, Karl-Heinz and Riserus, Ulf and Savolainen, Markku J. and Thorsdottir, Inga and Uusitupa, Matti and Hermansen, Kjeld},
  issn         = {1436-6215},
  keyword      = {Vitamin D,25-hydroxyvitamin D,Healthy Nordic diet,Nordic nutrition,recommendations,Metabolic syndrome},
  language     = {eng},
  number       = {4},
  pages        = {1123--1134},
  publisher    = {Springer},
  series       = {European Journal of Nutrition},
  title        = {Effects of a healthy Nordic diet on plasma 25-hydroxyvitamin D concentration in subjects with metabolic syndrome: a randomized, placebo-controlled trial (SYSDIET)},
  url          = {http://dx.doi.org/10.1007/s00394-014-0674-3},
  volume       = {53},
  year         = {2014},
}