Advanced

Magnetomotive Ultrasound Imaging Of Rat Lymph Nodes In Situ: Assessment Of Imaging Parameters

Evertsson, Maria LU ; Cinthio, Magnus LU ; Fredriksson, Sarah; Kjellman, Pontus LU ; in 't Zandt, René LU ; Olsson, Fredrik; Persson, Hans W LU and Jansson, Tomas LU (2013) IEEE International Ultrasonics Symposium (IUS), 2013 In 2013 IEEE International Ultrasonics Symposium (IUS) p.600-603
Abstract
Detection and removal sentinel lymph nodes (SLN) is important in the diagnosis and treatment of breast cancer and malignant melanoma. The SLN is the first regional lymph node draining the cancer tumor and if the cancer has spread it is most likely to find cancer cells in the SLN. In this study we have been able to detect multimodal superparamagnetic iron oxide nanoparticles (SPIO-NP) in rat SLNs in situ using magnetomotive ultrasound imaging (MMUS). In MMUS a time-varying external magnetic field acts to move the NPs and, thus, the NP-laden tissue. This movement can be detected by proper processing of ultrasound data. We have recently developed an MMUS algorithm, based on quadrature detection and phase gating at the frequency of NP... (More)
Detection and removal sentinel lymph nodes (SLN) is important in the diagnosis and treatment of breast cancer and malignant melanoma. The SLN is the first regional lymph node draining the cancer tumor and if the cancer has spread it is most likely to find cancer cells in the SLN. In this study we have been able to detect multimodal superparamagnetic iron oxide nanoparticles (SPIO-NP) in rat SLNs in situ using magnetomotive ultrasound imaging (MMUS). In MMUS a time-varying external magnetic field acts to move the NPs and, thus, the NP-laden tissue. This movement can be detected by proper processing of ultrasound data. We have recently developed an MMUS algorithm, based on quadrature detection and phase gating at the frequency of NP displacement, and this is the first study where the algorithm is evaluated in animals. For both higher NP-concentration, as well as smaller NPs, we found that the MMUS data showed a larger displacement (1.56 +/- 0.43 and 1.94 +/- 0.54 times larger, respectively). The MMUS displacement also increased with a lower excitation frequency (1.95 +/- 0.64 times larger for 5 Hz compared to 15 Hz) and higher excitation voltage (2.95 +/- 1.44 times larger for 30V compared to 10V). The results from this study show that the MMUS technique has potential to be used as bedside guidance during SLN surgery, well as being used as standalone technique in a number of other applications such as stem cell tracking and cardiovascular research. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Chapter in Book/Report/Conference proceeding
publication status
published
subject
keywords
Magnetomotive ultrasound imaging, multimodal imaging, molecular imaging, contrast agents, sentinel lymph nodes
in
2013 IEEE International Ultrasonics Symposium (IUS)
pages
600 - 603
publisher
IEEE--Institute of Electrical and Electronics Engineers Inc.
conference name
IEEE International Ultrasonics Symposium (IUS), 2013
external identifiers
  • wos:000336665300154
  • scopus:84894335884
ISBN
9781467356855
DOI
10.1109/ULTSYM.2013.0156
language
English
LU publication?
yes
id
6d07292d-69dc-4fd5-abbc-79156acb54c4 (old id 4558628)
date added to LUP
2014-07-24 11:18:38
date last changed
2017-02-14 13:00:00
@inproceedings{6d07292d-69dc-4fd5-abbc-79156acb54c4,
  abstract     = {Detection and removal sentinel lymph nodes (SLN) is important in the diagnosis and treatment of breast cancer and malignant melanoma. The SLN is the first regional lymph node draining the cancer tumor and if the cancer has spread it is most likely to find cancer cells in the SLN. In this study we have been able to detect multimodal superparamagnetic iron oxide nanoparticles (SPIO-NP) in rat SLNs in situ using magnetomotive ultrasound imaging (MMUS). In MMUS a time-varying external magnetic field acts to move the NPs and, thus, the NP-laden tissue. This movement can be detected by proper processing of ultrasound data. We have recently developed an MMUS algorithm, based on quadrature detection and phase gating at the frequency of NP displacement, and this is the first study where the algorithm is evaluated in animals. For both higher NP-concentration, as well as smaller NPs, we found that the MMUS data showed a larger displacement (1.56 +/- 0.43 and 1.94 +/- 0.54 times larger, respectively). The MMUS displacement also increased with a lower excitation frequency (1.95 +/- 0.64 times larger for 5 Hz compared to 15 Hz) and higher excitation voltage (2.95 +/- 1.44 times larger for 30V compared to 10V). The results from this study show that the MMUS technique has potential to be used as bedside guidance during SLN surgery, well as being used as standalone technique in a number of other applications such as stem cell tracking and cardiovascular research.},
  author       = {Evertsson, Maria and Cinthio, Magnus and Fredriksson, Sarah and Kjellman, Pontus and in 't Zandt, René and Olsson, Fredrik and Persson, Hans W and Jansson, Tomas},
  booktitle    = {2013 IEEE International Ultrasonics Symposium (IUS)},
  isbn         = {9781467356855},
  keyword      = {Magnetomotive ultrasound imaging,multimodal imaging,molecular imaging,contrast agents,sentinel lymph nodes},
  language     = {eng},
  pages        = {600--603},
  publisher    = {IEEE--Institute of Electrical and Electronics Engineers Inc.},
  title        = {Magnetomotive Ultrasound Imaging Of Rat Lymph Nodes In Situ: Assessment Of Imaging Parameters},
  url          = {http://dx.doi.org/10.1109/ULTSYM.2013.0156},
  year         = {2013},
}