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Collagenous colitis in systemic sclerosis: an overlooked and treatable complication.

Abignano, Giuseppina; Scott, Nigel; Wollheim, Frank LU ; Emery, Paul; Buch, Maya H and Del Galdo, Francesco (2014) In Journal of Clinical Rheumatology 20(5). p.278-282
Abstract
Collagenous colitis (CC) is an inflammatory bowel condition of unknown etiology. Systemic sclerosis (SSc) has been associated with CC in a few cases, but it is not clear whether CC could be considered an unusual manifestation of SSc or an independent condition. Here we present a case of SSc-associated CC and compare routine histology and immunofluorescence studies for allograft inflammatory factor 1 and caveolin 1 expression with other cases of CC and healthy controls. All CC biopsies showed characteristic sublaminal collagen accumulation and a decrease of caveolin 1 expression, this latter finding consistent with and common in any fibrotic reaction. In contrast, the expression of allograft inflammatory factor 1 was increased only in the... (More)
Collagenous colitis (CC) is an inflammatory bowel condition of unknown etiology. Systemic sclerosis (SSc) has been associated with CC in a few cases, but it is not clear whether CC could be considered an unusual manifestation of SSc or an independent condition. Here we present a case of SSc-associated CC and compare routine histology and immunofluorescence studies for allograft inflammatory factor 1 and caveolin 1 expression with other cases of CC and healthy controls. All CC biopsies showed characteristic sublaminal collagen accumulation and a decrease of caveolin 1 expression, this latter finding consistent with and common in any fibrotic reaction. In contrast, the expression of allograft inflammatory factor 1 was increased only in the SSc-CC specimen, suggesting a distinct pathogenesis. A literature review revealed 6 previously reported cases of SSc-CC with common clinical features. These observations suggest that CC should be suspected as a rare gastrointestinal complication of SSc and that clinicians should be aware of the possibility in SSc patients developing watery diarrhea. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Clinical Rheumatology
volume
20
issue
5
pages
278 - 282
publisher
Lippincott Williams & Wilkins
external identifiers
  • pmid:25036565
  • wos:000340374700008
  • scopus:84905123464
ISSN
1536-7355
DOI
10.1097/RHU.0000000000000121
language
English
LU publication?
yes
id
4be7433f-f898-40b3-97fd-7ab529e95c11 (old id 4581966)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/25036565?dopt=Abstract
date added to LUP
2014-08-08 17:30:05
date last changed
2017-01-01 04:05:13
@article{4be7433f-f898-40b3-97fd-7ab529e95c11,
  abstract     = {Collagenous colitis (CC) is an inflammatory bowel condition of unknown etiology. Systemic sclerosis (SSc) has been associated with CC in a few cases, but it is not clear whether CC could be considered an unusual manifestation of SSc or an independent condition. Here we present a case of SSc-associated CC and compare routine histology and immunofluorescence studies for allograft inflammatory factor 1 and caveolin 1 expression with other cases of CC and healthy controls. All CC biopsies showed characteristic sublaminal collagen accumulation and a decrease of caveolin 1 expression, this latter finding consistent with and common in any fibrotic reaction. In contrast, the expression of allograft inflammatory factor 1 was increased only in the SSc-CC specimen, suggesting a distinct pathogenesis. A literature review revealed 6 previously reported cases of SSc-CC with common clinical features. These observations suggest that CC should be suspected as a rare gastrointestinal complication of SSc and that clinicians should be aware of the possibility in SSc patients developing watery diarrhea.},
  author       = {Abignano, Giuseppina and Scott, Nigel and Wollheim, Frank and Emery, Paul and Buch, Maya H and Del Galdo, Francesco},
  issn         = {1536-7355},
  language     = {eng},
  number       = {5},
  pages        = {278--282},
  publisher    = {Lippincott Williams & Wilkins},
  series       = {Journal of Clinical Rheumatology},
  title        = {Collagenous colitis in systemic sclerosis: an overlooked and treatable complication.},
  url          = {http://dx.doi.org/10.1097/RHU.0000000000000121},
  volume       = {20},
  year         = {2014},
}