Screening Detects a High Proportion of Celiac Disease in Young HLA-genotyped Children.
(2010) In Journal of Pediatric Gastroenterology and Nutrition - Jpgn 50. p.49-53- Abstract
- BACKGROUND AND AIMS:: Celiac disease is associated with tissue transglutaminase autoantibodies (tTGAb) and the human leukocyte antigen (HLA)-risk alleles DQB1*02 and DQB1*0302. The aim was to estimate the proportion of undiagnosed celiac disease in children with HLA risk at 3 years of age. PATIENTS AND METHODS:: From a population-based HLA-DQ screening study of newborns born between June 2001 and August 2004 in the southern part of Sweden, 6206 children with HLA-risk alleles were identified and asked to participate at a mean 3.3 +/- 0.4 years of age. As controls, 7654 children with HLA-nonrisk alleles were asked to participate. In all, 1620 (26.1%) children with HLA risk and 1815 (23.7%) controls were screened for tTGAb using... (More)
- BACKGROUND AND AIMS:: Celiac disease is associated with tissue transglutaminase autoantibodies (tTGAb) and the human leukocyte antigen (HLA)-risk alleles DQB1*02 and DQB1*0302. The aim was to estimate the proportion of undiagnosed celiac disease in children with HLA risk at 3 years of age. PATIENTS AND METHODS:: From a population-based HLA-DQ screening study of newborns born between June 2001 and August 2004 in the southern part of Sweden, 6206 children with HLA-risk alleles were identified and asked to participate at a mean 3.3 +/- 0.4 years of age. As controls, 7654 children with HLA-nonrisk alleles were asked to participate. In all, 1620 (26.1%) children with HLA risk and 1815 (23.7%) controls were screened for tTGAb using radioligand-binding assays. Celiac disease was established by intestinal biopsy in children with a confirmed positive tTGAb test. RESULTS:: Twenty-three children reported already having clinically diagnosed celiac disease and did not participate further. In children with HLA-risk genotypes, 73 of 1620 (4.5%, 95% CI 3.5%-5.5%) were tTGAb-positive compared with none of 1815 from the controls (P < 0.0001). Seventy-one children underwent biopsy (1 refused biopsy and 1 biopsy failed), of whom 56 of 1618 (3.5%, 95% CI 2.6%-4.4%) had damaged intestinal mucosa classified as celiac disease. The ratio between clinically and screening detected celiac disease in this study was 1:2.4 (23:56). CONCLUSIONS:: The proportion of clinically undetected celiac disease may be particularly high among 3-year-old children with HLA-DQB1*02 and DQB1*0302 in Sweden, where these 2 HLA-risk alleles frequently occur. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1511905
- author
- Björck, Sara LU ; Brundin, Charlotte LU ; Lörinc, Ester LU ; Lynch, Kristian LU and Agardh, Daniel LU
- organization
- publishing date
- 2010
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Journal of Pediatric Gastroenterology and Nutrition - Jpgn
- volume
- 50
- pages
- 49 - 53
- publisher
- Lippincott Williams & Wilkins
- external identifiers
-
- wos:000273173700015
- pmid:19915493
- scopus:76149091543
- pmid:19915493
- ISSN
- 1536-4801
- DOI
- 10.1097/MPG.0b013e3181b477a6
- language
- English
- LU publication?
- yes
- id
- 45abf83d-a250-4cff-8efc-6f04ac360ad6 (old id 1511905)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/19915493?dopt=Abstract
- date added to LUP
- 2016-04-04 07:55:33
- date last changed
- 2022-02-20 21:02:17
@article{45abf83d-a250-4cff-8efc-6f04ac360ad6, abstract = {{BACKGROUND AND AIMS:: Celiac disease is associated with tissue transglutaminase autoantibodies (tTGAb) and the human leukocyte antigen (HLA)-risk alleles DQB1*02 and DQB1*0302. The aim was to estimate the proportion of undiagnosed celiac disease in children with HLA risk at 3 years of age. PATIENTS AND METHODS:: From a population-based HLA-DQ screening study of newborns born between June 2001 and August 2004 in the southern part of Sweden, 6206 children with HLA-risk alleles were identified and asked to participate at a mean 3.3 +/- 0.4 years of age. As controls, 7654 children with HLA-nonrisk alleles were asked to participate. In all, 1620 (26.1%) children with HLA risk and 1815 (23.7%) controls were screened for tTGAb using radioligand-binding assays. Celiac disease was established by intestinal biopsy in children with a confirmed positive tTGAb test. RESULTS:: Twenty-three children reported already having clinically diagnosed celiac disease and did not participate further. In children with HLA-risk genotypes, 73 of 1620 (4.5%, 95% CI 3.5%-5.5%) were tTGAb-positive compared with none of 1815 from the controls (P < 0.0001). Seventy-one children underwent biopsy (1 refused biopsy and 1 biopsy failed), of whom 56 of 1618 (3.5%, 95% CI 2.6%-4.4%) had damaged intestinal mucosa classified as celiac disease. The ratio between clinically and screening detected celiac disease in this study was 1:2.4 (23:56). CONCLUSIONS:: The proportion of clinically undetected celiac disease may be particularly high among 3-year-old children with HLA-DQB1*02 and DQB1*0302 in Sweden, where these 2 HLA-risk alleles frequently occur.}}, author = {{Björck, Sara and Brundin, Charlotte and Lörinc, Ester and Lynch, Kristian and Agardh, Daniel}}, issn = {{1536-4801}}, language = {{eng}}, pages = {{49--53}}, publisher = {{Lippincott Williams & Wilkins}}, series = {{Journal of Pediatric Gastroenterology and Nutrition - Jpgn}}, title = {{Screening Detects a High Proportion of Celiac Disease in Young HLA-genotyped Children.}}, url = {{http://dx.doi.org/10.1097/MPG.0b013e3181b477a6}}, doi = {{10.1097/MPG.0b013e3181b477a6}}, volume = {{50}}, year = {{2010}}, }