Changes in complex spike activity during classical conditioning
(2014) In Frontiers in Neural Circuits 8(90). p.13-90- Abstract
- The cerebellar cortex is necessary for adaptively timed conditioned responses (CRs) in eyeblink conditioning. During conditioning, Purkinje cells acquire pause responses or "Purkinje cell CRs" to the conditioned stimuli (CS), resulting in disinhibition of the cerebellar nuclei (CN), allowing them to activate motor nuclei that control eyeblinks. This disinhibition also causes inhibition of the inferior olive (IO), via the nucleo-olivary pathway (N-O). Activation of the IO, which relays the unconditional stimulus (US) to the cortex, elicits characteristic complex spikes in Purkinje cells. Although Purkinje cell activity, as well as stimulation of the CN, is known to influence IO activity, much remains to be learned about the way that learned... (More)
- The cerebellar cortex is necessary for adaptively timed conditioned responses (CRs) in eyeblink conditioning. During conditioning, Purkinje cells acquire pause responses or "Purkinje cell CRs" to the conditioned stimuli (CS), resulting in disinhibition of the cerebellar nuclei (CN), allowing them to activate motor nuclei that control eyeblinks. This disinhibition also causes inhibition of the inferior olive (IO), via the nucleo-olivary pathway (N-O). Activation of the IO, which relays the unconditional stimulus (US) to the cortex, elicits characteristic complex spikes in Purkinje cells. Although Purkinje cell activity, as well as stimulation of the CN, is known to influence IO activity, much remains to be learned about the way that learned changes in simple spike firing affects the IO. In the present study, we analyzed changes in simple and complex spike firing, in extracellular Purkinje cell records, from the C3 zone, in decerebrate ferrets undergoing training in a conditioning paradigm. In agreement with the N-O feedback hypothesis, acquisition resulted in a gradual decrease in complex spike activity during the conditioned stimulus, with a delay that is consistent with the long N-O latency. Also supporting the feedback hypothesis, training with a short interstimulus interval (ISI), which does not lead to acquisition of a Purkinje cell CR, did not cause a suppression of complex spike activity. In contrast, observations that extinction did not lead to a recovery in complex spike activity and the irregular patterns of simple and complex spike activity after the conditioned stimulus are less conclusive. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/4614245
- author
- Rasmussen, Anders
LU
; Jirenhed, Dan-Anders LU ; Wetmore, Daniel LU and Hesslow, Germund LU
- organization
- publishing date
- 2014
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Frontiers in Neural Circuits
- volume
- 8
- issue
- 90
- pages
- 13 - 90
- publisher
- Frontiers Media S. A.
- external identifiers
-
- pmid:25140129
- wos:000340084100001
- scopus:84905594072
- pmid:25140129
- ISSN
- 1662-5110
- DOI
- 10.3389/fncir.2014.00090
- project
- Thinking in Time: Cognition, Communication and Learning
- language
- English
- LU publication?
- yes
- id
- 2ce7e2e1-a6fb-4821-957a-c315ada0cc09 (old id 4614245)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/25140129?dopt=Abstract
- date added to LUP
- 2016-04-01 14:13:25
- date last changed
- 2022-05-16 12:08:52
@article{2ce7e2e1-a6fb-4821-957a-c315ada0cc09, abstract = {{The cerebellar cortex is necessary for adaptively timed conditioned responses (CRs) in eyeblink conditioning. During conditioning, Purkinje cells acquire pause responses or "Purkinje cell CRs" to the conditioned stimuli (CS), resulting in disinhibition of the cerebellar nuclei (CN), allowing them to activate motor nuclei that control eyeblinks. This disinhibition also causes inhibition of the inferior olive (IO), via the nucleo-olivary pathway (N-O). Activation of the IO, which relays the unconditional stimulus (US) to the cortex, elicits characteristic complex spikes in Purkinje cells. Although Purkinje cell activity, as well as stimulation of the CN, is known to influence IO activity, much remains to be learned about the way that learned changes in simple spike firing affects the IO. In the present study, we analyzed changes in simple and complex spike firing, in extracellular Purkinje cell records, from the C3 zone, in decerebrate ferrets undergoing training in a conditioning paradigm. In agreement with the N-O feedback hypothesis, acquisition resulted in a gradual decrease in complex spike activity during the conditioned stimulus, with a delay that is consistent with the long N-O latency. Also supporting the feedback hypothesis, training with a short interstimulus interval (ISI), which does not lead to acquisition of a Purkinje cell CR, did not cause a suppression of complex spike activity. In contrast, observations that extinction did not lead to a recovery in complex spike activity and the irregular patterns of simple and complex spike activity after the conditioned stimulus are less conclusive.}}, author = {{Rasmussen, Anders and Jirenhed, Dan-Anders and Wetmore, Daniel and Hesslow, Germund}}, issn = {{1662-5110}}, language = {{eng}}, number = {{90}}, pages = {{13--90}}, publisher = {{Frontiers Media S. A.}}, series = {{Frontiers in Neural Circuits}}, title = {{Changes in complex spike activity during classical conditioning}}, url = {{https://lup.lub.lu.se/search/files/3853116/7864279.pdf}}, doi = {{10.3389/fncir.2014.00090}}, volume = {{8}}, year = {{2014}}, }