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Flavonoid and lignan intake in relation to bladder cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) study.

Zamora-Ros, R; Sacerdote, C; Ricceri, F; Weiderpass, E; Roswall, N; Buckland, G; St-Jules, D E; Overvad, K; Kyrø, C and Fagherazzi, G, et al. (2014) In British Journal of Cancer 111(9). p.1870-1880
Abstract
Background:There is growing evidence of the protective role of dietary intake of flavonoids and lignans on cancer, but the association with bladder cancer has not been thoroughly investigated in epidemiological studies. We evaluated the association between dietary intakes of total and subclasses of flavonoids and lignans and risk of bladder cancer and its main morphological type, urothelial cell carcinoma (UCC), within the European Prospective Investigation into Cancer and Nutrition (EPIC) study.Methods:A cohort of 477 312 men and women mostly aged 35-70 years, were recruited in 10 European countries. At baseline, dietary flavonoid and lignan intakes were estimated using centre-specific validated questionnaires and a food composition... (More)
Background:There is growing evidence of the protective role of dietary intake of flavonoids and lignans on cancer, but the association with bladder cancer has not been thoroughly investigated in epidemiological studies. We evaluated the association between dietary intakes of total and subclasses of flavonoids and lignans and risk of bladder cancer and its main morphological type, urothelial cell carcinoma (UCC), within the European Prospective Investigation into Cancer and Nutrition (EPIC) study.Methods:A cohort of 477 312 men and women mostly aged 35-70 years, were recruited in 10 European countries. At baseline, dietary flavonoid and lignan intakes were estimated using centre-specific validated questionnaires and a food composition database based on the Phenol-Explorer, the UK Food Standards Agency and the US Department of Agriculture databases.Results:During an average of 11 years of follow-up, 1575 new cases of primary bladder cancer were identified, of which 1425 were UCC (classified into aggressive (n=430) and non-aggressive (n=413) UCC). No association was found between total flavonoid intake and bladder cancer risk. Among flavonoid subclasses, significant inverse associations with bladder cancer risk were found for intakes of flavonol (hazard ratio comparing fifth with first quintile (HRQ5-Q1) 0.74, 95% confidence interval (CI): 0.61-0.91; P-trend=0.009) and lignans (HRQ5-Q1 0.78, 95% CI: 0.62-0.96; P-trend=0.046). Similar results were observed for overall UCC and aggressive UCC, but not for non-aggressive UCC.Conclusions:Our study suggests an inverse association between the dietary intakes of flavonols and lignans and risk of bladder cancer, particularly aggressive UCC.British Journal of Cancer advance online publication, 14 August 2014; doi:10.1038/bjc.2014.459 www.bjcancer.com. (Less)
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British Journal of Cancer
volume
111
issue
9
pages
1870 - 1880
publisher
Nature Publishing Group
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  • pmid:25121955
  • wos:000344568600026
  • scopus:84908607376
ISSN
1532-1827
DOI
10.1038/bjc.2014.459
language
English
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yes
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61e600ae-383b-49db-a820-aad09f3ac748 (old id 4614727)
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http://www.ncbi.nlm.nih.gov/pubmed/25121955?dopt=Abstract
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2014-09-06 23:26:46
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2017-09-10 03:26:37
@article{61e600ae-383b-49db-a820-aad09f3ac748,
  abstract     = {Background:There is growing evidence of the protective role of dietary intake of flavonoids and lignans on cancer, but the association with bladder cancer has not been thoroughly investigated in epidemiological studies. We evaluated the association between dietary intakes of total and subclasses of flavonoids and lignans and risk of bladder cancer and its main morphological type, urothelial cell carcinoma (UCC), within the European Prospective Investigation into Cancer and Nutrition (EPIC) study.Methods:A cohort of 477 312 men and women mostly aged 35-70 years, were recruited in 10 European countries. At baseline, dietary flavonoid and lignan intakes were estimated using centre-specific validated questionnaires and a food composition database based on the Phenol-Explorer, the UK Food Standards Agency and the US Department of Agriculture databases.Results:During an average of 11 years of follow-up, 1575 new cases of primary bladder cancer were identified, of which 1425 were UCC (classified into aggressive (n=430) and non-aggressive (n=413) UCC). No association was found between total flavonoid intake and bladder cancer risk. Among flavonoid subclasses, significant inverse associations with bladder cancer risk were found for intakes of flavonol (hazard ratio comparing fifth with first quintile (HRQ5-Q1) 0.74, 95% confidence interval (CI): 0.61-0.91; P-trend=0.009) and lignans (HRQ5-Q1 0.78, 95% CI: 0.62-0.96; P-trend=0.046). Similar results were observed for overall UCC and aggressive UCC, but not for non-aggressive UCC.Conclusions:Our study suggests an inverse association between the dietary intakes of flavonols and lignans and risk of bladder cancer, particularly aggressive UCC.British Journal of Cancer advance online publication, 14 August 2014; doi:10.1038/bjc.2014.459 www.bjcancer.com.},
  author       = {Zamora-Ros, R and Sacerdote, C and Ricceri, F and Weiderpass, E and Roswall, N and Buckland, G and St-Jules, D E and Overvad, K and Kyrø, C and Fagherazzi, G and Kvaskoff, M and Severi, G and Chang-Claude, J and Kaaks, R and Nöthlings, U and Trichopoulou, A and Naska, A and Trichopoulos, D and Palli, D and Grioni, S and Mattiello, A and Tumino, R and Gram, I T and Engeset, D and Huerta, J M and Molina-Montes, E and Argüelles, M and Amiano, P and Ardanaz, E and Ericson, Ulrika and Lindkvist, B and Nilsson, L M and Kiemeney, L A and Ros, M and Bueno-de-Mesquita, H B and Peeters, P H M and Khaw, K-T and Wareham, N J and Knaze, V and Romieu, I and Scalbert, A and Brennan, P and Wark, P and Vineis, P and Riboli, E and González, C A},
  issn         = {1532-1827},
  language     = {eng},
  number       = {9},
  pages        = {1870--1880},
  publisher    = {Nature Publishing Group},
  series       = {British Journal of Cancer},
  title        = {Flavonoid and lignan intake in relation to bladder cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) study.},
  url          = {http://dx.doi.org/10.1038/bjc.2014.459},
  volume       = {111},
  year         = {2014},
}