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Interactions between polymorphisms in the aryl hydrocarbon receptor signalling pathway and exposure to persistent organochlorine pollutants affect human semen quality.

Brokken, Leon LU ; Lundberg, Johan P LU ; Spanò, M; Manicardi, G C; Pedersen, H S; Struciński, P; Góralczyk, K; Zviezdai, V; Jönsson, Bo A LU and Bonde, J P, et al. (2014) In Reproductive Toxicology 49(Jul 30). p.65-73
Abstract
Persistent organic pollutants (POPs) may affect male reproductive function. Many dioxin-like POPs exert their effects by activation of the aryl hydrocarbon receptor (AHR) signalling pathway. We analysed whether gene-environment interactions between polymorphisms in AHR (R554K) and AHR repressor (AHRR P185A) and serum levels of markers of POP exposure 1,1-bis-(4-chlorophenyl)-2,2-dichloroethene (p,p'-DDE) and 2,2',4,4',5,5'-hexachlorobiphenyl (CB-153) are associated with 21 parameters of male reproductive function in 581 proven-fertile European and Greenlandic men. In Greenlandic men, AHR variants significantly modified the association between serum levels of both p,p'-DDE and CB-153 and inhibin B levels, sperm chromatin integrity, and... (More)
Persistent organic pollutants (POPs) may affect male reproductive function. Many dioxin-like POPs exert their effects by activation of the aryl hydrocarbon receptor (AHR) signalling pathway. We analysed whether gene-environment interactions between polymorphisms in AHR (R554K) and AHR repressor (AHRR P185A) and serum levels of markers of POP exposure 1,1-bis-(4-chlorophenyl)-2,2-dichloroethene (p,p'-DDE) and 2,2',4,4',5,5'-hexachlorobiphenyl (CB-153) are associated with 21 parameters of male reproductive function in 581 proven-fertile European and Greenlandic men. In Greenlandic men, AHR variants significantly modified the association between serum levels of both p,p'-DDE and CB-153 and inhibin B levels, sperm chromatin integrity, and seminal zinc levels. In the total cohort, interactions between AHRR variants and serum levels of CB-153 were associated with sperm chromatin integrity and the expression of the pro-apoptotic marker protein Fas. The data indicate that susceptibility to adverse effects of POP exposure on male reproductive function is dependent on polymorphisms in genes involved in AHR signalling. (Less)
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Reproductive Toxicology
volume
49
issue
Jul 30
pages
65 - 73
publisher
Elsevier
external identifiers
  • pmid:25084496
  • wos:000345257900008
  • scopus:84907323511
ISSN
1873-1708
DOI
10.1016/j.reprotox.2014.07.073
language
English
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yes
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5a0aaef8-c16c-4470-8bec-d661e2b47012 (old id 4615701)
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http://www.ncbi.nlm.nih.gov/pubmed/25084496?dopt=Abstract
date added to LUP
2014-09-03 20:45:24
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2017-11-05 03:03:18
@article{5a0aaef8-c16c-4470-8bec-d661e2b47012,
  abstract     = {Persistent organic pollutants (POPs) may affect male reproductive function. Many dioxin-like POPs exert their effects by activation of the aryl hydrocarbon receptor (AHR) signalling pathway. We analysed whether gene-environment interactions between polymorphisms in AHR (R554K) and AHR repressor (AHRR P185A) and serum levels of markers of POP exposure 1,1-bis-(4-chlorophenyl)-2,2-dichloroethene (p,p'-DDE) and 2,2',4,4',5,5'-hexachlorobiphenyl (CB-153) are associated with 21 parameters of male reproductive function in 581 proven-fertile European and Greenlandic men. In Greenlandic men, AHR variants significantly modified the association between serum levels of both p,p'-DDE and CB-153 and inhibin B levels, sperm chromatin integrity, and seminal zinc levels. In the total cohort, interactions between AHRR variants and serum levels of CB-153 were associated with sperm chromatin integrity and the expression of the pro-apoptotic marker protein Fas. The data indicate that susceptibility to adverse effects of POP exposure on male reproductive function is dependent on polymorphisms in genes involved in AHR signalling.},
  author       = {Brokken, Leon and Lundberg, Johan P and Spanò, M and Manicardi, G C and Pedersen, H S and Struciński, P and Góralczyk, K and Zviezdai, V and Jönsson, Bo A and Bonde, J P and Toft, G and Giwercman, Yvonne and Giwercman, Aleksander},
  issn         = {1873-1708},
  language     = {eng},
  number       = {Jul 30},
  pages        = {65--73},
  publisher    = {Elsevier},
  series       = {Reproductive Toxicology},
  title        = {Interactions between polymorphisms in the aryl hydrocarbon receptor signalling pathway and exposure to persistent organochlorine pollutants affect human semen quality.},
  url          = {http://dx.doi.org/10.1016/j.reprotox.2014.07.073},
  volume       = {49},
  year         = {2014},
}