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Lung tissue bioengineering for transplantation and modelling of development, disease and regeneration

De Santis, Martina M. LU orcid ; Michielin, Federica ; Shibuya, Soichi ; Coppi, Paolo de and Wagner, Darcy E. LU orcid (2021) In ERS Monograph 2021(91). p.248-272
Abstract

The lung is a vital and dynamic organ that serves as a critical first barrier to environmental stimuli and facilitates gas exchange from birth until death. Developmental or genetic defects that impair lung function severely impact quality of life. Minor defects present in early life increase the likelihood that patients will develop chronic lung diseases in adulthood that have no cure. Current therapies aim to slow disease progression, with lung transplantation remaining the only option at end-stage disease. While a number of discoveries have been made using conventional cell culture and in vivo animal studies, new approaches are needed to develop effective therapies. Recent advances using bioengineering have created new models that... (More)

The lung is a vital and dynamic organ that serves as a critical first barrier to environmental stimuli and facilitates gas exchange from birth until death. Developmental or genetic defects that impair lung function severely impact quality of life. Minor defects present in early life increase the likelihood that patients will develop chronic lung diseases in adulthood that have no cure. Current therapies aim to slow disease progression, with lung transplantation remaining the only option at end-stage disease. While a number of discoveries have been made using conventional cell culture and in vivo animal studies, new approaches are needed to develop effective therapies. Recent advances using bioengineering have created new models that more closely recapitulate human development and disease. In parallel, progress has been made towards generating lung tissue in the laboratory with the ultimate aim of transplantation. This chapter covers the progress and recent advances in applying bioengineering approaches towards improving our understanding of lung development, disease and regeneration.

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Please use this url to cite or link to this publication:
author
; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
ERS Monograph
volume
2021
issue
91
pages
248 - 272
publisher
European Respiratory Society
external identifiers
  • scopus:85143111054
ISSN
2312-508X
DOI
10.1183/2312508X.10011020
language
English
LU publication?
yes
additional info
Publisher Copyright: © ERS 2021.
id
461e920e-ce7c-43d5-b8de-1bf3b3513947
date added to LUP
2023-07-16 19:19:37
date last changed
2023-07-24 15:35:07
@article{461e920e-ce7c-43d5-b8de-1bf3b3513947,
  abstract     = {{<p>The lung is a vital and dynamic organ that serves as a critical first barrier to environmental stimuli and facilitates gas exchange from birth until death. Developmental or genetic defects that impair lung function severely impact quality of life. Minor defects present in early life increase the likelihood that patients will develop chronic lung diseases in adulthood that have no cure. Current therapies aim to slow disease progression, with lung transplantation remaining the only option at end-stage disease. While a number of discoveries have been made using conventional cell culture and in vivo animal studies, new approaches are needed to develop effective therapies. Recent advances using bioengineering have created new models that more closely recapitulate human development and disease. In parallel, progress has been made towards generating lung tissue in the laboratory with the ultimate aim of transplantation. This chapter covers the progress and recent advances in applying bioengineering approaches towards improving our understanding of lung development, disease and regeneration.</p>}},
  author       = {{De Santis, Martina M. and Michielin, Federica and Shibuya, Soichi and Coppi, Paolo de and Wagner, Darcy E.}},
  issn         = {{2312-508X}},
  language     = {{eng}},
  number       = {{91}},
  pages        = {{248--272}},
  publisher    = {{European Respiratory Society}},
  series       = {{ERS Monograph}},
  title        = {{Lung tissue bioengineering for transplantation and modelling of development, disease and regeneration}},
  url          = {{http://dx.doi.org/10.1183/2312508X.10011020}},
  doi          = {{10.1183/2312508X.10011020}},
  volume       = {{2021}},
  year         = {{2021}},
}