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Celiac disease screening in children : evaluating the evidence, benefits, and challenges

Naredi Scherman, Maria LU ; Melin, Jessica LU and Agardh, Daniel LU (2025) In Frontiers in Pediatrics 13.
Abstract

Comprehensive screening of the general population is the only approach capable of identifying the majority of cases with celiac disease. In 2023, the Italian Parliament enacted a law to implement nationwide screening for celiac disease and type 1 diabetes. However, critical decisions regarding the target population, optimal timing, and screening methods remain unresolved. Previous observational studies on birth cohorts of children with genetic risk for these conditions have demonstrated that the incidence peaks early in life and is influenced by HLA risk genotypes. This mini-review explores different aspects of screening for celiac disease, presenting the advantages and challenges of identifying children before onset of symptoms. In... (More)

Comprehensive screening of the general population is the only approach capable of identifying the majority of cases with celiac disease. In 2023, the Italian Parliament enacted a law to implement nationwide screening for celiac disease and type 1 diabetes. However, critical decisions regarding the target population, optimal timing, and screening methods remain unresolved. Previous observational studies on birth cohorts of children with genetic risk for these conditions have demonstrated that the incidence peaks early in life and is influenced by HLA risk genotypes. This mini-review explores different aspects of screening for celiac disease, presenting the advantages and challenges of identifying children before onset of symptoms. In addition, we summarize the current knowledge and gaps in understanding related to screening programs for celiac disease in children and adolescents and discuss health benefits, psychosocial aspects and cost-effectiveness, and their potential implications for future public health strategies.

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Please use this url to cite or link to this publication:
author
; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
celiac disease, children, costeffectiveness, HLA, population, quality of life, screening, transglutaminase antibody
in
Frontiers in Pediatrics
volume
13
article number
1562073
publisher
Frontiers Media S. A.
external identifiers
  • scopus:105002703188
  • pmid:40248017
ISSN
2296-2360
DOI
10.3389/fped.2025.1562073
language
English
LU publication?
yes
id
46830478-5a9e-48c7-9f6b-fe748fe91975
date added to LUP
2025-08-29 12:01:12
date last changed
2025-08-30 03:00:08
@article{46830478-5a9e-48c7-9f6b-fe748fe91975,
  abstract     = {{<p>Comprehensive screening of the general population is the only approach capable of identifying the majority of cases with celiac disease. In 2023, the Italian Parliament enacted a law to implement nationwide screening for celiac disease and type 1 diabetes. However, critical decisions regarding the target population, optimal timing, and screening methods remain unresolved. Previous observational studies on birth cohorts of children with genetic risk for these conditions have demonstrated that the incidence peaks early in life and is influenced by HLA risk genotypes. This mini-review explores different aspects of screening for celiac disease, presenting the advantages and challenges of identifying children before onset of symptoms. In addition, we summarize the current knowledge and gaps in understanding related to screening programs for celiac disease in children and adolescents and discuss health benefits, psychosocial aspects and cost-effectiveness, and their potential implications for future public health strategies.</p>}},
  author       = {{Naredi Scherman, Maria and Melin, Jessica and Agardh, Daniel}},
  issn         = {{2296-2360}},
  keywords     = {{celiac disease; children; costeffectiveness; HLA; population; quality of life; screening; transglutaminase antibody}},
  language     = {{eng}},
  publisher    = {{Frontiers Media S. A.}},
  series       = {{Frontiers in Pediatrics}},
  title        = {{Celiac disease screening in children : evaluating the evidence, benefits, and challenges}},
  url          = {{http://dx.doi.org/10.3389/fped.2025.1562073}},
  doi          = {{10.3389/fped.2025.1562073}},
  volume       = {{13}},
  year         = {{2025}},
}