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Neuropeptide Y is a minor autoantigen in newly diagnosed type 1 diabetes patients.

Skärstrand, Hanna LU ; Vaziri Sani, Fariba LU ; Delli, Ahmed LU ; Törn, Carina LU ; Larsson, Helena LU ; Ivarsson, Sten LU ; Agardh, Daniel LU and Lernmark, Åke LU (2015) In Pediatric Diabetes 16(8). p.621-628
Abstract
Autoantibodies (A) against Neuropeptide Y (NPY), was reported in 9% newly diagnosed type 1 diabetes (T1D) patients. A single nucleotide polymorphism (SNP) at rs16139 (T1128C) within the NPY-gene identified an amino acid substitution from leucine (L) to proline (P) (L7P) associated with both glucose tolerance and type 2 diabetes. We aimed to determine: (i) the influence of autoantibodies to leucine neuropeptide Y (NPY-LA) and autoantibodies to proline neuropeptide Y (NPY-PA) on the diagnostic sensitivity of type 1 diabetes (T1D), (ii) the association of NPYA with major islet autoantibodies, and (iii) the association of NPYA with HLA-DQ genotypes in newly diagnosed T1D patients.
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Pediatric Diabetes
volume
16
issue
8
pages
621 - 628
publisher
Wiley-Blackwell
external identifiers
  • pmid:25258030
  • wos:000363929400009
  • scopus:84946476107
ISSN
1399-543X
DOI
10.1111/pedi.12222
language
English
LU publication?
yes
id
4ee07cca-b889-4aea-8f18-aa024f6cd775 (old id 4690890)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/25258030?dopt=Abstract
date added to LUP
2014-10-08 16:23:40
date last changed
2017-06-11 03:13:00
@article{4ee07cca-b889-4aea-8f18-aa024f6cd775,
  abstract     = {Autoantibodies (A) against Neuropeptide Y (NPY), was reported in 9% newly diagnosed type 1 diabetes (T1D) patients. A single nucleotide polymorphism (SNP) at rs16139 (T1128C) within the NPY-gene identified an amino acid substitution from leucine (L) to proline (P) (L7P) associated with both glucose tolerance and type 2 diabetes. We aimed to determine: (i) the influence of autoantibodies to leucine neuropeptide Y (NPY-LA) and autoantibodies to proline neuropeptide Y (NPY-PA) on the diagnostic sensitivity of type 1 diabetes (T1D), (ii) the association of NPYA with major islet autoantibodies, and (iii) the association of NPYA with HLA-DQ genotypes in newly diagnosed T1D patients.},
  author       = {Skärstrand, Hanna and Vaziri Sani, Fariba and Delli, Ahmed and Törn, Carina and Larsson, Helena and Ivarsson, Sten and Agardh, Daniel and Lernmark, Åke},
  issn         = {1399-543X},
  language     = {eng},
  number       = {8},
  pages        = {621--628},
  publisher    = {Wiley-Blackwell},
  series       = {Pediatric Diabetes},
  title        = {Neuropeptide Y is a minor autoantigen in newly diagnosed type 1 diabetes patients.},
  url          = {http://dx.doi.org/10.1111/pedi.12222},
  volume       = {16},
  year         = {2015},
}