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Suicidal patients are deficient in vitamin D, associated with a pro-inflammatory status in the blood.

Grudet, Cécile LU ; Malm, Johan LU ; Westrin, Åsa LU and Brundin, Lena LU (2014) In Psychoneuroendocrinology 50. p.210-219
Abstract
Low levels of vitamin D may play a role in psychiatric disorders, as cross-sectional studies show an association between vitamin D deficiency and depression, schizophrenia and psychotic symptoms. The underlying mechanisms are not well understood, although vitamin D is known to influence the immune system to promote a T helper (Th)-2 phenotype. At the same time, increased inflammation might be of importance in the pathophysiology of depression and suicide. We therefore hypothesized that suicidal patients would be deficient in vitamin D, which could be responsible for the inflammatory changes observed in these patients.
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Psychoneuroendocrinology
volume
50
pages
210 - 219
publisher
Elsevier
external identifiers
  • pmid:25240206
  • wos:000345061000020
  • scopus:84908413262
ISSN
1873-3360
DOI
10.1016/j.psyneuen.2014.08.016
language
English
LU publication?
yes
id
f9985da7-fb8e-44f5-beee-b9cfd55a9a45 (old id 4691155)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/25240206?dopt=Abstract
date added to LUP
2014-10-07 22:28:50
date last changed
2017-09-10 03:01:40
@article{f9985da7-fb8e-44f5-beee-b9cfd55a9a45,
  abstract     = {Low levels of vitamin D may play a role in psychiatric disorders, as cross-sectional studies show an association between vitamin D deficiency and depression, schizophrenia and psychotic symptoms. The underlying mechanisms are not well understood, although vitamin D is known to influence the immune system to promote a T helper (Th)-2 phenotype. At the same time, increased inflammation might be of importance in the pathophysiology of depression and suicide. We therefore hypothesized that suicidal patients would be deficient in vitamin D, which could be responsible for the inflammatory changes observed in these patients.},
  author       = {Grudet, Cécile and Malm, Johan and Westrin, Åsa and Brundin, Lena},
  issn         = {1873-3360},
  language     = {eng},
  pages        = {210--219},
  publisher    = {Elsevier},
  series       = {Psychoneuroendocrinology},
  title        = {Suicidal patients are deficient in vitamin D, associated with a pro-inflammatory status in the blood.},
  url          = {http://dx.doi.org/10.1016/j.psyneuen.2014.08.016},
  volume       = {50},
  year         = {2014},
}