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Associations between cadmium exposure and circulating levels of sex hormones in postmenopausal women.

Ali, Imran; Engström, Annette; Vahter, Marie; Skerfving, Staffan LU ; Lundh, Thomas LU ; Lidfeldt, Jonas LU ; Samsioe, Göran LU ; Halldin, Krister and Akesson, Agneta (2014) In Environmental Research 134. p.265-269
Abstract
Recent epidemiological as well as in vivo and in vitro studies collectively suggest that the metalloestrogen cadmium (Cd) could be a potential risk factor for hormone-related cancers in particularly breast cancer. Assessment of the association between Cd exposure and levels of endogenous sex hormones is of pivotal importance, as increased levels of such have been associated with a higher risk of breast cancer in postmenopausal women. The present study investigated the perceived relationship (multivariable-adjusted linear regression analyses) between Cd exposure [blood Cd (B-Cd) and urinary Cd (U-Cd)], and serum levels of androstenedione, testosterone, estradiol, and sex-hormone binding globulin (SHBG), in 438 postmenopausal Swedish women... (More)
Recent epidemiological as well as in vivo and in vitro studies collectively suggest that the metalloestrogen cadmium (Cd) could be a potential risk factor for hormone-related cancers in particularly breast cancer. Assessment of the association between Cd exposure and levels of endogenous sex hormones is of pivotal importance, as increased levels of such have been associated with a higher risk of breast cancer in postmenopausal women. The present study investigated the perceived relationship (multivariable-adjusted linear regression analyses) between Cd exposure [blood Cd (B-Cd) and urinary Cd (U-Cd)], and serum levels of androstenedione, testosterone, estradiol, and sex-hormone binding globulin (SHBG), in 438 postmenopausal Swedish women without hormone replacement therapy (HRT). A significant positive association between B-Cd (median 3.4nmol/L) and serum testosterone levels, as well as a significant inverse association between B-Cd and serum estradiol levels and with the estradiol/testosterone ratio were encountered. However, U-Cd (median 0.69nmol/mmol creatinine) was inversely associated with serum estradiol levels only. Our data may suggest that Cd interferes with the levels of testosterone and estradiol in postmenopausal women, which might have implications for breast cancer risk. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Environmental Research
volume
134
pages
265 - 269
publisher
Elsevier
external identifiers
  • pmid:25173093
  • wos:000346817100036
  • scopus:84907379372
ISSN
1096-0953
DOI
10.1016/j.envres.2014.08.009
language
English
LU publication?
yes
id
c7c5b810-a656-45fc-bb68-846d66372192 (old id 4692854)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/25173093?dopt=Abstract
date added to LUP
2014-10-01 11:15:50
date last changed
2017-01-01 03:11:02
@article{c7c5b810-a656-45fc-bb68-846d66372192,
  abstract     = {Recent epidemiological as well as in vivo and in vitro studies collectively suggest that the metalloestrogen cadmium (Cd) could be a potential risk factor for hormone-related cancers in particularly breast cancer. Assessment of the association between Cd exposure and levels of endogenous sex hormones is of pivotal importance, as increased levels of such have been associated with a higher risk of breast cancer in postmenopausal women. The present study investigated the perceived relationship (multivariable-adjusted linear regression analyses) between Cd exposure [blood Cd (B-Cd) and urinary Cd (U-Cd)], and serum levels of androstenedione, testosterone, estradiol, and sex-hormone binding globulin (SHBG), in 438 postmenopausal Swedish women without hormone replacement therapy (HRT). A significant positive association between B-Cd (median 3.4nmol/L) and serum testosterone levels, as well as a significant inverse association between B-Cd and serum estradiol levels and with the estradiol/testosterone ratio were encountered. However, U-Cd (median 0.69nmol/mmol creatinine) was inversely associated with serum estradiol levels only. Our data may suggest that Cd interferes with the levels of testosterone and estradiol in postmenopausal women, which might have implications for breast cancer risk.},
  author       = {Ali, Imran and Engström, Annette and Vahter, Marie and Skerfving, Staffan and Lundh, Thomas and Lidfeldt, Jonas and Samsioe, Göran and Halldin, Krister and Akesson, Agneta},
  issn         = {1096-0953},
  language     = {eng},
  pages        = {265--269},
  publisher    = {Elsevier},
  series       = {Environmental Research},
  title        = {Associations between cadmium exposure and circulating levels of sex hormones in postmenopausal women.},
  url          = {http://dx.doi.org/10.1016/j.envres.2014.08.009},
  volume       = {134},
  year         = {2014},
}