Theoretical considerations for understanding a Purkinje cell timing mechanism
(2014) In Communicative & Integrative Biology 7(6). p.994376-994376- Abstract
- In classical conditioning, cerebellar Purkinje cells learn an adaptively timed pause in spontaneous firing. This pause reaches its maximum near the end of the interstimulus interval. While it was thought that this timing was due to temporal patterns in the input signal and selective engagement of changes in synapse strength, we have shown Purkinje cells learn timed responses even when the conditional stimulus is delivered to its immediate afferents.(1) This shows that Purkinje cells have a cellular timing mechanism. The cellular models of intrinsic timing we are aware of are based on adapting the rise time of the concentration of a given ion. As an alternative, we here propose a selection mechanism in abstract terms for how a Purkinje cell... (More)
- In classical conditioning, cerebellar Purkinje cells learn an adaptively timed pause in spontaneous firing. This pause reaches its maximum near the end of the interstimulus interval. While it was thought that this timing was due to temporal patterns in the input signal and selective engagement of changes in synapse strength, we have shown Purkinje cells learn timed responses even when the conditional stimulus is delivered to its immediate afferents.(1) This shows that Purkinje cells have a cellular timing mechanism. The cellular models of intrinsic timing we are aware of are based on adapting the rise time of the concentration of a given ion. As an alternative, we here propose a selection mechanism in abstract terms for how a Purkinje cell could learn to respond at a particular time after an external trigger. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/4698371
- author
- Johansson, Fredrik LU and Hesslow, Germund LU
- organization
- publishing date
- 2014
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Communicative & Integrative Biology
- volume
- 7
- issue
- 6
- pages
- 994376 - 994376
- publisher
- Landes Bioscience
- external identifiers
-
- pmid:26479712
- scopus:84922962665
- pmid:26479712
- ISSN
- 1942-0889
- DOI
- 10.4161/19420889.2014.994376
- project
- Thinking in Time: Cognition, Communication and Learning
- language
- English
- LU publication?
- yes
- id
- 5081507a-cec1-4f34-b239-ba84389f5890 (old id 4698371)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/26479712?dopt=Abstract
- date added to LUP
- 2016-04-01 14:37:41
- date last changed
- 2022-03-29 22:03:05
@article{5081507a-cec1-4f34-b239-ba84389f5890,
abstract = {{In classical conditioning, cerebellar Purkinje cells learn an adaptively timed pause in spontaneous firing. This pause reaches its maximum near the end of the interstimulus interval. While it was thought that this timing was due to temporal patterns in the input signal and selective engagement of changes in synapse strength, we have shown Purkinje cells learn timed responses even when the conditional stimulus is delivered to its immediate afferents.(1) This shows that Purkinje cells have a cellular timing mechanism. The cellular models of intrinsic timing we are aware of are based on adapting the rise time of the concentration of a given ion. As an alternative, we here propose a selection mechanism in abstract terms for how a Purkinje cell could learn to respond at a particular time after an external trigger.}},
author = {{Johansson, Fredrik and Hesslow, Germund}},
issn = {{1942-0889}},
language = {{eng}},
number = {{6}},
pages = {{994376--994376}},
publisher = {{Landes Bioscience}},
series = {{Communicative & Integrative Biology}},
title = {{Theoretical considerations for understanding a Purkinje cell timing mechanism}},
url = {{https://lup.lub.lu.se/search/files/4073497/7754308}},
doi = {{10.4161/19420889.2014.994376}},
volume = {{7}},
year = {{2014}},
}