Mucoadhesion : mucin-polymer molecular interactions
Pham, Quoc Dat LU ; Nöjd, Sofi LU ; Edman, Martin ; Lindell, Katarina ; Topgaard, Daniel LU and Wahlgren, Marie LU
(2021)
In International Journal of Pharmaceutics
610.
- Abstract
Mucoadhesion, adhesion of a material to a mucous membrane or a mucus-covered surface, has been employed in drug delivery to prolong contact with adsorption sites and consequently a likely improvement of drug absorption. Mucoadhesion in the oral cavity also provides additional effects on tactile mouthfeel and extended flavor delivery, which impact consumer perception. The mechanisms behind mucoadhesion have not been well understood and there are contradictory literature results on the ranking of mucoadhesive properties of different polymers based on what in-vitro methods that are used. We herein examine the molecular interactions of different polymers with mucin from bovine submaxillary glands at pH 6.6 by using 1H NMR... (More)
Mucoadhesion, adhesion of a material to a mucous membrane or a mucus-covered surface, has been employed in drug delivery to prolong contact with adsorption sites and consequently a likely improvement of drug absorption. Mucoadhesion in the oral cavity also provides additional effects on tactile mouthfeel and extended flavor delivery, which impact consumer perception. The mechanisms behind mucoadhesion have not been well understood and there are contradictory literature results on the ranking of mucoadhesive properties of different polymers based on what in-vitro methods that are used. We herein examine the molecular interactions of different polymers with mucin from bovine submaxillary glands at pH 6.6 by using 1H NMR (Nuclear Magnetic Resonance) that provides atomically resolved information on conformational mobility of the mucin. Studying different types of polymers with different chemical structures and degrees of polymerization (DP), we can via the NMR linewidths and the signal intensities distinguish if the polymers interact with specific segments of the mucin or if they have a universal effect on the mobility of all the molecular segments of the mucin. The specific interaction sites on the mucin for positively charged polymer poly(ethyleneimine) are shown to be different from those for negatively and neutrally charged polymers. In addition, the interactions are also driven by the DP, the concentration of the polymers, and the dehydration. Deepened understanding of molecular effects of the different polymers on the mucin can therefore have strong impact on the development of mucoadhesive products in pharmaceutical and food applications. Finally, we raise awareness of the interpretation of rheological data in terms of mucoadhesion.
(Less)
- author
- Pham, Quoc Dat
LU
; Nöjd, Sofi
LU
; Edman, Martin
; Lindell, Katarina
; Topgaard, Daniel
LU
and Wahlgren, Marie
LU
- organization
- publishing date
- 2021-12-15
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Dynamics, Hydration, Mobility, NMR, Rheology
- in
- International Journal of Pharmaceutics
- volume
- 610
- article number
- 121245
- pages
- 9 pages
- publisher
- Elsevier
- external identifiers
-
- scopus:85118583283
- pmid:34755651
- ISSN
- 0378-5173
- DOI
- 10.1016/j.ijpharm.2021.121245
- language
- English
- LU publication?
- yes
- additional info
- Publisher Copyright: © 2021 The Authors
- id
- 4720635e-a337-4f4e-8ab0-9a4019f027c6
- date added to LUP
- 2021-11-17 21:57:20
- date last changed
- 2024-04-20 16:36:35
@article{4720635e-a337-4f4e-8ab0-9a4019f027c6,
abstract = {{<p>Mucoadhesion, adhesion of a material to a mucous membrane or a mucus-covered surface, has been employed in drug delivery to prolong contact with adsorption sites and consequently a likely improvement of drug absorption. Mucoadhesion in the oral cavity also provides additional effects on tactile mouthfeel and extended flavor delivery, which impact consumer perception. The mechanisms behind mucoadhesion have not been well understood and there are contradictory literature results on the ranking of mucoadhesive properties of different polymers based on what in-vitro methods that are used. We herein examine the molecular interactions of different polymers with mucin from bovine submaxillary glands at pH 6.6 by using <sup>1</sup>H NMR (Nuclear Magnetic Resonance) that provides atomically resolved information on conformational mobility of the mucin. Studying different types of polymers with different chemical structures and degrees of polymerization (DP), we can via the NMR linewidths and the signal intensities distinguish if the polymers interact with specific segments of the mucin or if they have a universal effect on the mobility of all the molecular segments of the mucin. The specific interaction sites on the mucin for positively charged polymer poly(ethyleneimine) are shown to be different from those for negatively and neutrally charged polymers. In addition, the interactions are also driven by the DP, the concentration of the polymers, and the dehydration. Deepened understanding of molecular effects of the different polymers on the mucin can therefore have strong impact on the development of mucoadhesive products in pharmaceutical and food applications. Finally, we raise awareness of the interpretation of rheological data in terms of mucoadhesion.</p>}},
author = {{Pham, Quoc Dat and Nöjd, Sofi and Edman, Martin and Lindell, Katarina and Topgaard, Daniel and Wahlgren, Marie}},
issn = {{0378-5173}},
keywords = {{Dynamics; Hydration; Mobility; NMR; Rheology}},
language = {{eng}},
month = {{12}},
publisher = {{Elsevier}},
series = {{International Journal of Pharmaceutics}},
title = {{Mucoadhesion : mucin-polymer molecular interactions}},
url = {{http://dx.doi.org/10.1016/j.ijpharm.2021.121245}},
doi = {{10.1016/j.ijpharm.2021.121245}},
volume = {{610}},
year = {{2021}},
}