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Evaluation of Algorithms for the Treatment of Problem Bleeding Episodes in Patients With Hemophilia Having Inhibitors.

Young, Guy; Teitel, Jerome; d'Oiron, Roseline; Leissinger, Cindy and Berntorp, Erik LU (2015) In Clinical and Applied Thrombosis/Hemostasis 21(1). p.10-18
Abstract
The correlation between real-world clinical decisions and adherence to published treatment algorithms for problem bleeding episodes in patients with severe hemophilia and inhibitors and the resultant impact on clinical outcomes were assessed. Nine cases documenting treatment for problem bleeding episodes in patients with severe hemophilia and inhibitors were retrospectively reviewed. Adherence to treatment algorithms was rated on a scale of 1 to 5, 1 being no adherence and 5 being very high adherence. Adherence ratings >3 were assigned to 7 cases in which high adherence was associated with ≤4 days to achieve hemostatic control; hospitalization for ≤7 days was noted in 6 of these cases. In cases rated ≤3 (n = 2), time to hemostatic... (More)
The correlation between real-world clinical decisions and adherence to published treatment algorithms for problem bleeding episodes in patients with severe hemophilia and inhibitors and the resultant impact on clinical outcomes were assessed. Nine cases documenting treatment for problem bleeding episodes in patients with severe hemophilia and inhibitors were retrospectively reviewed. Adherence to treatment algorithms was rated on a scale of 1 to 5, 1 being no adherence and 5 being very high adherence. Adherence ratings >3 were assigned to 7 cases in which high adherence was associated with ≤4 days to achieve hemostatic control; hospitalization for ≤7 days was noted in 6 of these cases. In cases rated ≤3 (n = 2), time to hemostatic control ranged from 5 to 8 days and hospitalization duration ranged from 10 to 16 days. These findings suggest that adherence to treatment algorithms may be beneficial in treating problem bleeding events in patients with hemophilia and inhibitors. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Clinical and Applied Thrombosis/Hemostasis
volume
21
issue
1
pages
10 - 18
external identifiers
  • pmid:25343956
  • wos:000345894700002
  • scopus:84914146074
ISSN
1938-2723
DOI
10.1177/1076029614554993
language
English
LU publication?
yes
id
e602a20b-a947-4f5d-99c4-6020d11f5868 (old id 4733282)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/25343956?dopt=Abstract
date added to LUP
2014-11-10 18:53:51
date last changed
2017-07-23 03:30:36
@article{e602a20b-a947-4f5d-99c4-6020d11f5868,
  abstract     = {The correlation between real-world clinical decisions and adherence to published treatment algorithms for problem bleeding episodes in patients with severe hemophilia and inhibitors and the resultant impact on clinical outcomes were assessed. Nine cases documenting treatment for problem bleeding episodes in patients with severe hemophilia and inhibitors were retrospectively reviewed. Adherence to treatment algorithms was rated on a scale of 1 to 5, 1 being no adherence and 5 being very high adherence. Adherence ratings >3 were assigned to 7 cases in which high adherence was associated with ≤4 days to achieve hemostatic control; hospitalization for ≤7 days was noted in 6 of these cases. In cases rated ≤3 (n = 2), time to hemostatic control ranged from 5 to 8 days and hospitalization duration ranged from 10 to 16 days. These findings suggest that adherence to treatment algorithms may be beneficial in treating problem bleeding events in patients with hemophilia and inhibitors.},
  author       = {Young, Guy and Teitel, Jerome and d'Oiron, Roseline and Leissinger, Cindy and Berntorp, Erik},
  issn         = {1938-2723},
  language     = {eng},
  number       = {1},
  pages        = {10--18},
  series       = {Clinical and Applied Thrombosis/Hemostasis},
  title        = {Evaluation of Algorithms for the Treatment of Problem Bleeding Episodes in Patients With Hemophilia Having Inhibitors.},
  url          = {http://dx.doi.org/10.1177/1076029614554993},
  volume       = {21},
  year         = {2015},
}