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Optimal experimental design for filter exchange imaging: Apparent exchange rate measurements in the healthy brain and in intracranial tumors.

Lampinen, Björn LU ; Szczepankiewicz, Filip LU ; van Westen, Danielle LU ; Englund, Elisabet LU ; Sundgren, Pia LU ; Lätt, Jimmy LU ; Ståhlberg, Freddy LU and Nilsson, Markus LU (2017) In Magnetic Resonance in Medicine 77(3). p.1104-1114
Abstract

PURPOSE: Filter exchange imaging (FEXI) is sensitive to the rate of diffusional water exchange, which depends, eg, on the cell membrane permeability. The aim was to optimize and analyze the ability of FEXI to infer differences in the apparent exchange rate (AXR) in the brain between two populations.

METHODS: A FEXI protocol was optimized for minimal measurement variance in the AXR. The AXR variance was investigated by test-retest acquisitions in six brain regions in 18 healthy volunteers. Preoperative FEXI data and postoperative microphotos were obtained in six meningiomas and five astrocytomas.

RESULTS: Protocol optimization reduced the coefficient of variation of AXR by approximately 40%. Test-retest AXR values were... (More)

PURPOSE: Filter exchange imaging (FEXI) is sensitive to the rate of diffusional water exchange, which depends, eg, on the cell membrane permeability. The aim was to optimize and analyze the ability of FEXI to infer differences in the apparent exchange rate (AXR) in the brain between two populations.

METHODS: A FEXI protocol was optimized for minimal measurement variance in the AXR. The AXR variance was investigated by test-retest acquisitions in six brain regions in 18 healthy volunteers. Preoperative FEXI data and postoperative microphotos were obtained in six meningiomas and five astrocytomas.

RESULTS: Protocol optimization reduced the coefficient of variation of AXR by approximately 40%. Test-retest AXR values were heterogeneous across normal brain regions, from 0.3 ± 0.2 s-1 in the corpus callosum to 1.8 ± 0.3 s-1 in the frontal white matter. According to analysis of statistical power, in all brain regions except one, group differences of 0.3-0.5 s-1 in the AXR can be inferred using 5 to 10 subjects per group. An AXR difference of this magnitude was observed between meningiomas (0.6 ± 0.1 s-1 ) and astrocytomas (1.0 ± 0.3 s-1 ).

CONCLUSIONS: With the optimized protocol, FEXI has the ability to infer relevant differences in the AXR between two populations for small group sizes. Magn Reson Med 77:1104-1114, 2017.

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Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
cell membrane permeability, diffusion MRI, filter exchange imaging, study design
in
Magnetic Resonance in Medicine
volume
77
issue
3
pages
11 pages
publisher
John Wiley and Sons Inc.
external identifiers
  • pmid:26968557
  • scopus:84960539189
  • pmid:26968557
  • wos:000397407800019
  • scopus:85013127595
ISSN
1522-2594
DOI
10.1002/mrm.26195
language
English
LU publication?
yes
id
47603af2-eaac-4553-ad2e-63926adb0aa5 (old id 8852642)
date added to LUP
2016-04-01 10:45:31
date last changed
2020-08-05 01:30:27
@article{47603af2-eaac-4553-ad2e-63926adb0aa5,
  abstract     = {<p>PURPOSE: Filter exchange imaging (FEXI) is sensitive to the rate of diffusional water exchange, which depends, eg, on the cell membrane permeability. The aim was to optimize and analyze the ability of FEXI to infer differences in the apparent exchange rate (AXR) in the brain between two populations.</p><p>METHODS: A FEXI protocol was optimized for minimal measurement variance in the AXR. The AXR variance was investigated by test-retest acquisitions in six brain regions in 18 healthy volunteers. Preoperative FEXI data and postoperative microphotos were obtained in six meningiomas and five astrocytomas.</p><p>RESULTS: Protocol optimization reduced the coefficient of variation of AXR by approximately 40%. Test-retest AXR values were heterogeneous across normal brain regions, from 0.3 ± 0.2 s-1 in the corpus callosum to 1.8 ± 0.3 s-1 in the frontal white matter. According to analysis of statistical power, in all brain regions except one, group differences of 0.3-0.5 s-1 in the AXR can be inferred using 5 to 10 subjects per group. An AXR difference of this magnitude was observed between meningiomas (0.6 ± 0.1 s-1 ) and astrocytomas (1.0 ± 0.3 s-1 ).</p><p>CONCLUSIONS: With the optimized protocol, FEXI has the ability to infer relevant differences in the AXR between two populations for small group sizes. Magn Reson Med 77:1104-1114, 2017.</p>},
  author       = {Lampinen, Björn and Szczepankiewicz, Filip and van Westen, Danielle and Englund, Elisabet and Sundgren, Pia and Lätt, Jimmy and Ståhlberg, Freddy and Nilsson, Markus},
  issn         = {1522-2594},
  language     = {eng},
  number       = {3},
  pages        = {1104--1114},
  publisher    = {John Wiley and Sons Inc.},
  series       = {Magnetic Resonance in Medicine},
  title        = {Optimal experimental design for filter exchange imaging: Apparent exchange rate measurements in the healthy brain and in intracranial tumors.},
  url          = {http://dx.doi.org/10.1002/mrm.26195},
  doi          = {10.1002/mrm.26195},
  volume       = {77},
  year         = {2017},
}