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The Effect on Melanoma Risk of Genes Previously Associated With Telomere Length

Iles, Mark M.; Bishop, D. Timothy; Taylor, John C.; Hayward, Nicholas K.; Brossard, Myriam; Cust, Anne E.; Dunning, Alison M.; Lee, Jeffrey E.; Moses, Eric K. and Akslen, Lars A., et al. (2014) In Journal of the National Cancer Institute 106(10). p.267-267
Abstract
Telomere length has been associated with risk of many cancers, but results are inconsistent. Seven single nucleotide polymorphisms (SNPs) previously associated with mean leukocyte telomere length were either genotyped or well-imputed in 11 108 case patients and 13 933 control patients from Europe, Israel, the United States and Australia, four of the seven SNPs reached a P value under .05 (two-sided). A genetic score that predicts telomere length, derived from these seven SNPs, is strongly associated (P = 8.92x10(-9), two-sided) with melanoma risk. This demonstrates that the previously observed association between longer telomere length and increased melanoma risk is not attributable to confounding via shared environmental effects (such as... (More)
Telomere length has been associated with risk of many cancers, but results are inconsistent. Seven single nucleotide polymorphisms (SNPs) previously associated with mean leukocyte telomere length were either genotyped or well-imputed in 11 108 case patients and 13 933 control patients from Europe, Israel, the United States and Australia, four of the seven SNPs reached a P value under .05 (two-sided). A genetic score that predicts telomere length, derived from these seven SNPs, is strongly associated (P = 8.92x10(-9), two-sided) with melanoma risk. This demonstrates that the previously observed association between longer telomere length and increased melanoma risk is not attributable to confounding via shared environmental effects (such as ultraviolet exposure) or reverse causality. We provide the first proof that multiple germline genetic determinants of telomere length influence cancer risk. (Less)
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publication status
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Journal of the National Cancer Institute
volume
106
issue
10
pages
267 - 267
publisher
Oxford University Press
external identifiers
  • wos:000343038200014
  • scopus:84930397756
ISSN
1460-2105
DOI
10.1093/jnci/dju267
language
English
LU publication?
yes
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3819497b-2474-44d6-aa6a-aac2f02e43a1 (old id 4787379)
date added to LUP
2014-12-01 07:36:33
date last changed
2017-10-29 03:58:56
@article{3819497b-2474-44d6-aa6a-aac2f02e43a1,
  abstract     = {Telomere length has been associated with risk of many cancers, but results are inconsistent. Seven single nucleotide polymorphisms (SNPs) previously associated with mean leukocyte telomere length were either genotyped or well-imputed in 11 108 case patients and 13 933 control patients from Europe, Israel, the United States and Australia, four of the seven SNPs reached a P value under .05 (two-sided). A genetic score that predicts telomere length, derived from these seven SNPs, is strongly associated (P = 8.92x10(-9), two-sided) with melanoma risk. This demonstrates that the previously observed association between longer telomere length and increased melanoma risk is not attributable to confounding via shared environmental effects (such as ultraviolet exposure) or reverse causality. We provide the first proof that multiple germline genetic determinants of telomere length influence cancer risk.},
  author       = {Iles, Mark M. and Bishop, D. Timothy and Taylor, John C. and Hayward, Nicholas K. and Brossard, Myriam and Cust, Anne E. and Dunning, Alison M. and Lee, Jeffrey E. and Moses, Eric K. and Akslen, Lars A. and Andresen, Per A. and Avril, Marie-Francoise and Azizi, Esther and Scarra, Giovanna Bianchi and Brown, Kevin M. and Debniak, Tadeusz and Elder, David E. and Friedman, Eitan and Ghiorzo, Paola and Gillanders, Elizabeth M. and Goldstein, Alisa M. and Gruis, Nelleke A. and Hansson, Johan and Harland, Mark and Helsing, Per and Hocevar, Marko and Hoiom, Veronica and Ingvar, Christian and Kanetsky, Peter A. and Landi, Maria Teresa and Lang, Julie and Lathrop, G. Mark and Lubinski, Jan and Mackie, Rona M. and Martin, Nicholas G. and Molven, Anders and Montgomery, Grant W. and Novakovic, Srdjan and Olsson, Håkan and Puig, Susana and Anton Puig-Butille, Joan and Radford-Smith, Graham L. and Randerson-Moor, Juliette and van der Stoep, Nienke and van Doorn, Remco and Whiteman, David C. and MacGregor, Stuart and Pooley, Karen A. and Ward, Sarah V. and Mann, Graham J. and Amos, Christopher I. and Pharoah, Paul D. P. and Demenais, Florence and Law, Matthew H. and Bishop, Julia A. Newton and Barrett, Jennifer H.},
  issn         = {1460-2105},
  language     = {eng},
  number       = {10},
  pages        = {267--267},
  publisher    = {Oxford University Press},
  series       = {Journal of the National Cancer Institute},
  title        = {The Effect on Melanoma Risk of Genes Previously Associated With Telomere Length},
  url          = {http://dx.doi.org/10.1093/jnci/dju267},
  volume       = {106},
  year         = {2014},
}