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Obese children aged 4–6 displayed decreased fasting and postprandial ghrelin levels in response to a test meal

Önnerfält, Jenny LU ; Erlanson-Albertsson, Charlotte LU ; Montelius, Caroline LU and Thorngren-Jerneck, Kristina LU (2018) In Acta Paediatrica, International Journal of Paediatrics 107(3). p.523-528
Abstract

Aim: Ghrelin is a hunger hormone that plays a role in glucose homoeostasis and its levels increase before a meal and decrease during and after eating. This study compared the fasting ghrelin and insulin levels of obese children aged 4–6 with those of normal weight children and tested postprandial ghrelin levels in the obese children after a standard breakfast. Methods: We recruited 67 children at Lund University Hospital from 2008 to 2011. They comprised 30 obese children from a weight study and 37 normal weight children receiving minor elective surgery. Their mean ages were 4.7 ± 0.6 and 4.3 ± 0.8 years, respectively. The obese children ate a standard breakfast, and postprandial ghrelin was measured after 60 minutes. Results: The obese... (More)

Aim: Ghrelin is a hunger hormone that plays a role in glucose homoeostasis and its levels increase before a meal and decrease during and after eating. This study compared the fasting ghrelin and insulin levels of obese children aged 4–6 with those of normal weight children and tested postprandial ghrelin levels in the obese children after a standard breakfast. Methods: We recruited 67 children at Lund University Hospital from 2008 to 2011. They comprised 30 obese children from a weight study and 37 normal weight children receiving minor elective surgery. Their mean ages were 4.7 ± 0.6 and 4.3 ± 0.8 years, respectively. The obese children ate a standard breakfast, and postprandial ghrelin was measured after 60 minutes. Results: The obese children had lower ghrelin levels than the controls (p < 0.01). A significant inverse relation was found between body mass index and fasting ghrelin levels. Obese children had significantly lower fasting ghrelin levels after a standard breakfast (p < 0.01), but there were no gender-related differences. Conclusion: Obese children aged 4–6 years had reduced ghrelin and increased insulin levels in the fasting state and postprandial ghrelin was suppressed, suggesting that their energy metabolism was already dysregulated at this young age. Early obesity interventions are essential.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Children, Ghrelin, Insulin, Obesity, Postprandial
in
Acta Paediatrica, International Journal of Paediatrics
volume
107
issue
3
pages
6 pages
publisher
Wiley-Blackwell Publishing Ltd
external identifiers
  • scopus:85041794294
ISSN
0803-5253
DOI
10.1111/apa.14165
language
English
LU publication?
yes
id
47afb64f-7b8b-4ebe-a678-e65b5a6fc604
date added to LUP
2018-02-20 14:17:59
date last changed
2018-05-29 11:16:46
@article{47afb64f-7b8b-4ebe-a678-e65b5a6fc604,
  abstract     = {<p>Aim: Ghrelin is a hunger hormone that plays a role in glucose homoeostasis and its levels increase before a meal and decrease during and after eating. This study compared the fasting ghrelin and insulin levels of obese children aged 4–6 with those of normal weight children and tested postprandial ghrelin levels in the obese children after a standard breakfast. Methods: We recruited 67 children at Lund University Hospital from 2008 to 2011. They comprised 30 obese children from a weight study and 37 normal weight children receiving minor elective surgery. Their mean ages were 4.7 ± 0.6 and 4.3 ± 0.8 years, respectively. The obese children ate a standard breakfast, and postprandial ghrelin was measured after 60 minutes. Results: The obese children had lower ghrelin levels than the controls (p &lt; 0.01). A significant inverse relation was found between body mass index and fasting ghrelin levels. Obese children had significantly lower fasting ghrelin levels after a standard breakfast (p &lt; 0.01), but there were no gender-related differences. Conclusion: Obese children aged 4–6 years had reduced ghrelin and increased insulin levels in the fasting state and postprandial ghrelin was suppressed, suggesting that their energy metabolism was already dysregulated at this young age. Early obesity interventions are essential.</p>},
  author       = {Önnerfält, Jenny and Erlanson-Albertsson, Charlotte and Montelius, Caroline and Thorngren-Jerneck, Kristina},
  issn         = {0803-5253},
  keyword      = {Children,Ghrelin,Insulin,Obesity,Postprandial},
  language     = {eng},
  number       = {3},
  pages        = {523--528},
  publisher    = {Wiley-Blackwell Publishing Ltd},
  series       = {Acta Paediatrica, International Journal of Paediatrics},
  title        = {Obese children aged 4–6 displayed decreased fasting and postprandial ghrelin levels in response to a test meal},
  url          = {http://dx.doi.org/10.1111/apa.14165},
  volume       = {107},
  year         = {2018},
}