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Inflammation, oxidative stress and genotoxicity responses to biodiesel emissions in cultured mammalian cells and animals

Møller, Peter ; Scholten, Rebecca Harnung ; Roursgaard, Martin and Krais, Annette M. LU orcid (2020) In Critical Reviews in Toxicology 50(5). p.383-401
Abstract

Biodiesel fuels are alternatives to petrodiesel, especially in the transport sector where they have lower carbon footprint. Notwithstanding the environmental benefit, biodiesel fuels may have other toxicological properties than petrodiesel. Particulate matter (PM) from petrodiesel causes cancer in the lung as a consequence of delivery of genotoxic polycyclic aromatic hydrocarbons, oxidative stress and inflammation. We have reviewed articles from 2002 to 2019 (50% of the articles since 2015) that have described toxicological effects in terms of genotoxicity, oxidative stress and inflammation of biodiesel exhaust exposure in humans, animals and cell cultures. The studies have assessed first generation biodiesel from different feedstock... (More)

Biodiesel fuels are alternatives to petrodiesel, especially in the transport sector where they have lower carbon footprint. Notwithstanding the environmental benefit, biodiesel fuels may have other toxicological properties than petrodiesel. Particulate matter (PM) from petrodiesel causes cancer in the lung as a consequence of delivery of genotoxic polycyclic aromatic hydrocarbons, oxidative stress and inflammation. We have reviewed articles from 2002 to 2019 (50% of the articles since 2015) that have described toxicological effects in terms of genotoxicity, oxidative stress and inflammation of biodiesel exhaust exposure in humans, animals and cell cultures. The studies have assessed first generation biodiesel from different feedstock (e.g. rapeseed and soy), certain second generation fuels (e.g. waste oil), and hydrogenated vegetable oil. It is not possible to rank the potency of toxicological effects of specific biodiesel fuels. However, exposure to biodiesel exhaust causes oxidative stress, inflammation and genotoxicity in cell cultures. Three studies in animals have not indicated genotoxicity in lung tissue. The database on oxidative stress and inflammation in animal studies is larger (13 studies); ten studies have reported increased levels of oxidative stress biomarkers or inflammation, although the effects have been modest in most studies. The cell culture and animal studies have not consistently shown a different potency in effect between biodiesel and petrodiesel exhausts. Both increased and decreased potency have been reported, which might be due to differences in feedstock or combustion conditions. In conclusion, combustion products from biodiesel and petrodiesel fuel may evoke similar toxicological effects on genotoxicity, oxidative stress and inflammation.

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author
; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
animal models, Biodiesel, DNA damage, inflammation, in vitro, oxidative stress
in
Critical Reviews in Toxicology
volume
50
issue
5
pages
19 pages
publisher
Taylor & Francis
external identifiers
  • pmid:32543270
  • scopus:85086939515
ISSN
1040-8444
DOI
10.1080/10408444.2020.1762541
language
English
LU publication?
yes
id
47baf361-c992-4bcb-a415-733983feb879
date added to LUP
2020-07-13 11:45:07
date last changed
2024-08-22 00:13:47
@article{47baf361-c992-4bcb-a415-733983feb879,
  abstract     = {{<p>Biodiesel fuels are alternatives to petrodiesel, especially in the transport sector where they have lower carbon footprint. Notwithstanding the environmental benefit, biodiesel fuels may have other toxicological properties than petrodiesel. Particulate matter (PM) from petrodiesel causes cancer in the lung as a consequence of delivery of genotoxic polycyclic aromatic hydrocarbons, oxidative stress and inflammation. We have reviewed articles from 2002 to 2019 (50% of the articles since 2015) that have described toxicological effects in terms of genotoxicity, oxidative stress and inflammation of biodiesel exhaust exposure in humans, animals and cell cultures. The studies have assessed first generation biodiesel from different feedstock (e.g. rapeseed and soy), certain second generation fuels (e.g. waste oil), and hydrogenated vegetable oil. It is not possible to rank the potency of toxicological effects of specific biodiesel fuels. However, exposure to biodiesel exhaust causes oxidative stress, inflammation and genotoxicity in cell cultures. Three studies in animals have not indicated genotoxicity in lung tissue. The database on oxidative stress and inflammation in animal studies is larger (13 studies); ten studies have reported increased levels of oxidative stress biomarkers or inflammation, although the effects have been modest in most studies. The cell culture and animal studies have not consistently shown a different potency in effect between biodiesel and petrodiesel exhausts. Both increased and decreased potency have been reported, which might be due to differences in feedstock or combustion conditions. In conclusion, combustion products from biodiesel and petrodiesel fuel may evoke similar toxicological effects on genotoxicity, oxidative stress and inflammation.</p>}},
  author       = {{Møller, Peter and Scholten, Rebecca Harnung and Roursgaard, Martin and Krais, Annette M.}},
  issn         = {{1040-8444}},
  keywords     = {{animal models; Biodiesel; DNA damage; inflammation; in vitro; oxidative stress}},
  language     = {{eng}},
  month        = {{06}},
  number       = {{5}},
  pages        = {{383--401}},
  publisher    = {{Taylor & Francis}},
  series       = {{Critical Reviews in Toxicology}},
  title        = {{Inflammation, oxidative stress and genotoxicity responses to biodiesel emissions in cultured mammalian cells and animals}},
  url          = {{http://dx.doi.org/10.1080/10408444.2020.1762541}},
  doi          = {{10.1080/10408444.2020.1762541}},
  volume       = {{50}},
  year         = {{2020}},
}