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The influence of methylphenidate on auditory brainstem response patients with attention deficit hyperactivity disorder; an exploratory study

Claesdotter-Knutsson, Emma LU ; Källstrand, Johan ; Niklasson, Katalin LU ; Andersson, Mitchell LU orcid and Lindvall, Magnus LU (2023) In Journal of Public Health Research 12(4).
Abstract
Background:
Attention-deficit hyperactivity disorder (ADHD), characterized by periods of inattention, overactivity, and impulsiveness, is the most prevalent neurodevelopmental disorder among children. Auditory Brainstem Response (ABR) is a technique in which clickshaped sounds elicit potentials that are recorded from electrodes placed on a patient’s skull. Extant research indicates that ABR is frequently affected in neurodevelopmental disorders such as ADHD. Methylphenidate (MPH), a psychostimulant, is often prescribed to children with ADHD as a first-line pharmacological treatment. The aim of this study was to explore the effects of Methylphenidate treatment on previously observed amplitude alterations in the ABR of patients with... (More)
Background:
Attention-deficit hyperactivity disorder (ADHD), characterized by periods of inattention, overactivity, and impulsiveness, is the most prevalent neurodevelopmental disorder among children. Auditory Brainstem Response (ABR) is a technique in which clickshaped sounds elicit potentials that are recorded from electrodes placed on a patient’s skull. Extant research indicates that ABR is frequently affected in neurodevelopmental disorders such as ADHD. Methylphenidate (MPH), a psychostimulant, is often prescribed to children with ADHD as a first-line pharmacological treatment. The aim of this study was to explore the effects of Methylphenidate treatment on previously observed amplitude alterations in the ABR of patients with ADHD.
Methods:
We recruited 32 drug-naïve children and adolescents (19 males and 13 females; mean age 11 years) diagnosed with ADHD and 35 health controls (15 males and 20 females; mean age 12 years). The ADHD group was treated with Methylphenidate, and ABR was recorded before treatment and at a steady state of medical treatment.
Results:
Medicated ADHD patients exhibited increased activity in the right side ABR in Wave VI.
Conclusions:
A significant increase in activity was found in a part of the ABR thought to correspond to the thalamic area in medicated ADHD patients compared to the same area of non-medicated ADHD patients. The results add to the growing body of research suggesting that specific ABR peaks correlate to certain psychiatric symptoms. (Less)
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author
; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Public Health Research
volume
12
issue
4
publisher
Page Press
external identifiers
  • scopus:85175695054
ISSN
2279-9028
DOI
10.1177/22799036231204
language
English
LU publication?
yes
id
480ecb65-2f60-426b-b57e-cbda63bc4795
date added to LUP
2023-10-25 11:58:58
date last changed
2023-11-23 15:11:14
@article{480ecb65-2f60-426b-b57e-cbda63bc4795,
  abstract     = {{Background:<br/>Attention-deficit hyperactivity disorder (ADHD), characterized by periods of inattention, overactivity, and impulsiveness, is the most prevalent neurodevelopmental disorder among children. Auditory Brainstem Response (ABR) is a technique in which clickshaped sounds elicit potentials that are recorded from electrodes placed on a patient’s skull. Extant research indicates that ABR is frequently affected in neurodevelopmental disorders such as ADHD. Methylphenidate (MPH), a psychostimulant, is often prescribed to children with ADHD as a first-line pharmacological treatment. The aim of this study was to explore the effects of Methylphenidate treatment on previously observed amplitude alterations in the ABR of patients with ADHD.<br/>Methods:<br/>We recruited 32 drug-naïve children and adolescents (19 males and 13 females; mean age 11 years) diagnosed with ADHD and 35 health controls (15 males and 20 females; mean age 12 years). The ADHD group was treated with Methylphenidate, and ABR was recorded before treatment and at a steady state of medical treatment.<br/>Results:<br/>Medicated ADHD patients exhibited increased activity in the right side ABR in Wave VI.<br/>Conclusions:<br/>A significant increase in activity was found in a part of the ABR thought to correspond to the thalamic area in medicated ADHD patients compared to the same area of non-medicated ADHD patients. The results add to the growing body of research suggesting that specific ABR peaks correlate to certain psychiatric symptoms.}},
  author       = {{Claesdotter-Knutsson, Emma and Källstrand, Johan and Niklasson, Katalin and Andersson, Mitchell and Lindvall, Magnus}},
  issn         = {{2279-9028}},
  language     = {{eng}},
  number       = {{4}},
  publisher    = {{Page Press}},
  series       = {{Journal of Public Health Research}},
  title        = {{The influence of methylphenidate on auditory brainstem response patients with attention deficit hyperactivity disorder; an exploratory study}},
  url          = {{http://dx.doi.org/10.1177/22799036231204}},
  doi          = {{10.1177/22799036231204}},
  volume       = {{12}},
  year         = {{2023}},
}