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Regulation of Pancreatic Beta Cell Stimulus-Secretion Coupling by microRNAs.

Esguerra, Jonathan LU ; Mollet, Ines LU ; Salunkhe, Vishal Ashok LU ; Wendt, Anna LU and Eliasson, Lena LU (2014) In Genes 5(4). p.1018-1031
Abstract
Increased blood glucose after a meal is countered by the subsequent increased release of the hypoglycemic hormone insulin from the pancreatic beta cells. The cascade of molecular events encompassing the initial sensing and transport of glucose into the beta cell, culminating with the exocytosis of the insulin large dense core granules (LDCVs) is termed "stimulus-secretion coupling." Impairment in any of the relevant processes leads to insufficient insulin release, which contributes to the development of type 2 diabetes (T2D). The fate of the beta cell, when exposed to environmental triggers of the disease, is determined by the possibility to adapt to the new situation by regulation of gene expression. As established factors of... (More)
Increased blood glucose after a meal is countered by the subsequent increased release of the hypoglycemic hormone insulin from the pancreatic beta cells. The cascade of molecular events encompassing the initial sensing and transport of glucose into the beta cell, culminating with the exocytosis of the insulin large dense core granules (LDCVs) is termed "stimulus-secretion coupling." Impairment in any of the relevant processes leads to insufficient insulin release, which contributes to the development of type 2 diabetes (T2D). The fate of the beta cell, when exposed to environmental triggers of the disease, is determined by the possibility to adapt to the new situation by regulation of gene expression. As established factors of post-transcriptional regulation, microRNAs (miRNAs) are well-recognized mediators of beta cell plasticity and adaptation. Here, we put focus on the importance of comprehending the transcriptional regulation of miRNAs, and how miRNAs are implicated in stimulus-secretion coupling, specifically those influencing the late stages of insulin secretion. We suggest that efficient beta cell adaptation requires an optimal balance between transcriptional regulation of miRNAs themselves, and miRNA-dependent gene regulation. The increased knowledge of the beta cell transcriptional network inclusive of non-coding RNAs such as miRNAs is essential in identifying novel targets for the treatment of T2D. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Genes
volume
5
issue
4
pages
1018 - 1031
publisher
MDPI AG
external identifiers
  • pmid:25383562
  • wos:000348858000007
  • scopus:84908672563
ISSN
2073-4425
DOI
10.3390/genes5041018
language
English
LU publication?
yes
id
aa0c27ed-24f0-4a4c-a3fa-7ee0f2c3c84b (old id 4817068)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/25383562?dopt=Abstract
date added to LUP
2014-12-01 20:43:43
date last changed
2017-09-24 03:49:06
@article{aa0c27ed-24f0-4a4c-a3fa-7ee0f2c3c84b,
  abstract     = {Increased blood glucose after a meal is countered by the subsequent increased release of the hypoglycemic hormone insulin from the pancreatic beta cells. The cascade of molecular events encompassing the initial sensing and transport of glucose into the beta cell, culminating with the exocytosis of the insulin large dense core granules (LDCVs) is termed "stimulus-secretion coupling." Impairment in any of the relevant processes leads to insufficient insulin release, which contributes to the development of type 2 diabetes (T2D). The fate of the beta cell, when exposed to environmental triggers of the disease, is determined by the possibility to adapt to the new situation by regulation of gene expression. As established factors of post-transcriptional regulation, microRNAs (miRNAs) are well-recognized mediators of beta cell plasticity and adaptation. Here, we put focus on the importance of comprehending the transcriptional regulation of miRNAs, and how miRNAs are implicated in stimulus-secretion coupling, specifically those influencing the late stages of insulin secretion. We suggest that efficient beta cell adaptation requires an optimal balance between transcriptional regulation of miRNAs themselves, and miRNA-dependent gene regulation. The increased knowledge of the beta cell transcriptional network inclusive of non-coding RNAs such as miRNAs is essential in identifying novel targets for the treatment of T2D.},
  author       = {Esguerra, Jonathan and Mollet, Ines and Salunkhe, Vishal Ashok and Wendt, Anna and Eliasson, Lena},
  issn         = {2073-4425},
  language     = {eng},
  number       = {4},
  pages        = {1018--1031},
  publisher    = {MDPI AG},
  series       = {Genes},
  title        = {Regulation of Pancreatic Beta Cell Stimulus-Secretion Coupling by microRNAs.},
  url          = {http://dx.doi.org/10.3390/genes5041018},
  volume       = {5},
  year         = {2014},
}