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Association between insulin-like growth factor-1 receptor (IGF1R) negativity and poor prognosis in a cohort of women with primary breast cancer.

Aaltonen, Kristina LU ; Rosendahl, Ann LU ; Olsson, Hans; Malmström, Per LU ; Werner Hartman, Linda LU and Fernö, Mårten LU (2014) In BMC Cancer 14.
Abstract
Resistance towards endocrine therapy is a great concern in breast cancer treatment and may partly be explained by the activation of compensatory signaling pathways. The aim of the present study was to investigate if the insulin-like growth factor-1 receptor (IGF1R) signaling pathway was activated or deregulated in breast cancer patients and to explore if any of the markers were prognostic, with or without adjuvant tamoxifen. This signaling pathway has been suggested to cause estrogen independent cell growth and thus contribute to resistance to endocrine treatment in estrogen receptor (ER) positive breast cancer.
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
BMC Cancer
volume
14
publisher
BioMed Central
external identifiers
  • pmid:25362932
  • wos:000345113300001
  • scopus:84920811592
ISSN
1471-2407
DOI
10.1186/1471-2407-14-794
language
English
LU publication?
yes
id
a96728c4-f469-44df-90d5-598b0e200400 (old id 4820413)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/25362932?dopt=Abstract
date added to LUP
2014-12-01 18:33:37
date last changed
2017-05-28 04:11:12
@article{a96728c4-f469-44df-90d5-598b0e200400,
  abstract     = {Resistance towards endocrine therapy is a great concern in breast cancer treatment and may partly be explained by the activation of compensatory signaling pathways. The aim of the present study was to investigate if the insulin-like growth factor-1 receptor (IGF1R) signaling pathway was activated or deregulated in breast cancer patients and to explore if any of the markers were prognostic, with or without adjuvant tamoxifen. This signaling pathway has been suggested to cause estrogen independent cell growth and thus contribute to resistance to endocrine treatment in estrogen receptor (ER) positive breast cancer.},
  articleno    = {794},
  author       = {Aaltonen, Kristina and Rosendahl, Ann and Olsson, Hans and Malmström, Per and Werner Hartman, Linda and Fernö, Mårten},
  issn         = {1471-2407},
  language     = {eng},
  publisher    = {BioMed Central},
  series       = {BMC Cancer},
  title        = {Association between insulin-like growth factor-1 receptor (IGF1R) negativity and poor prognosis in a cohort of women with primary breast cancer.},
  url          = {http://dx.doi.org/10.1186/1471-2407-14-794},
  volume       = {14},
  year         = {2014},
}