Advanced

Local treatments for metastases of renal cell carcinoma: a systematic review

Dabestani, Saeed LU ; Marconi, Lorenzo; Hofmann, Fabian; Stewart, Fiona; Lam, Thomas B. L.; Canfield, Steven E.; Staehler, Michael; Powles, Thomas; Ljungberg, Boerje and Bex, Axel (2014) In The Lancet Oncology 15(12). p.549-561
Abstract
Local treatment of metastases such as metastasectomy or radiotherapy remains controversial in the treatment of metastatic renal cell carcinoma. To investigate the benefits and harms of various local treatments, we did a systematic review of all types of comparative studies on local treatment of metastases from renal cell carcinoma in any organ. Interventions included metastasectomy, radiotherapy modalities, and no local treatment. The results suggest that patients treated with complete metastasectomy have better survival and symptom control (including pain relief in bone metastases) than those treated with either incomplete or no metastasectomy. Nevertheless, the available evidence was marred by high risks of bias and confounding across... (More)
Local treatment of metastases such as metastasectomy or radiotherapy remains controversial in the treatment of metastatic renal cell carcinoma. To investigate the benefits and harms of various local treatments, we did a systematic review of all types of comparative studies on local treatment of metastases from renal cell carcinoma in any organ. Interventions included metastasectomy, radiotherapy modalities, and no local treatment. The results suggest that patients treated with complete metastasectomy have better survival and symptom control (including pain relief in bone metastases) than those treated with either incomplete or no metastasectomy. Nevertheless, the available evidence was marred by high risks of bias and confounding across all studies. Although the findings presented here should be interpreted with caution, they and the identified gaps in knowledge should provide guidance for clinicians and researchers, and directions for further research. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
The Lancet Oncology
volume
15
issue
12
pages
549 - 561
publisher
Elsevier
external identifiers
  • wos:000344546400023
  • pmid:25439697
  • scopus:84908590983
ISSN
1474-5488
DOI
10.1016/S1470-2045(14)70235-9
language
English
LU publication?
yes
id
4a5d5e59-fc00-42ef-8e44-3726b7c04bd9 (old id 4865350)
date added to LUP
2015-01-07 10:31:43
date last changed
2017-10-22 03:17:04
@article{4a5d5e59-fc00-42ef-8e44-3726b7c04bd9,
  abstract     = {Local treatment of metastases such as metastasectomy or radiotherapy remains controversial in the treatment of metastatic renal cell carcinoma. To investigate the benefits and harms of various local treatments, we did a systematic review of all types of comparative studies on local treatment of metastases from renal cell carcinoma in any organ. Interventions included metastasectomy, radiotherapy modalities, and no local treatment. The results suggest that patients treated with complete metastasectomy have better survival and symptom control (including pain relief in bone metastases) than those treated with either incomplete or no metastasectomy. Nevertheless, the available evidence was marred by high risks of bias and confounding across all studies. Although the findings presented here should be interpreted with caution, they and the identified gaps in knowledge should provide guidance for clinicians and researchers, and directions for further research.},
  author       = {Dabestani, Saeed and Marconi, Lorenzo and Hofmann, Fabian and Stewart, Fiona and Lam, Thomas B. L. and Canfield, Steven E. and Staehler, Michael and Powles, Thomas and Ljungberg, Boerje and Bex, Axel},
  issn         = {1474-5488},
  language     = {eng},
  number       = {12},
  pages        = {549--561},
  publisher    = {Elsevier},
  series       = {The Lancet Oncology},
  title        = {Local treatments for metastases of renal cell carcinoma: a systematic review},
  url          = {http://dx.doi.org/10.1016/S1470-2045(14)70235-9},
  volume       = {15},
  year         = {2014},
}