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Epigenetic–smoking interaction reveals histologically heterogeneous effects of TRIM27 DNA methylation on overall survival among early-stage NSCLC patients

Ji, Xinyu ; Lin, Lijuan ; Shen, Sipeng ; Dong, Xuesi ; Chen, Chao ; Li, Yi ; Zhu, Ying ; Huang, Hui ; Chen, Jiajin and Chen, Xin , et al. (2020) In Molecular Oncology 14(11). p.2759-2774
Abstract

Tripartite motif containing 27 (TRIM27) is highly expressed in lung cancer, including non-small-cell lung cancer (NSCLC). Here, we profiled DNA methylation of lung adenocarcinoma (LUAD) and lung squamous cell carcinoma (LUSC) tumours from 613 early-stage NSCLC patients and evaluated associations between CpG methylation of TRIM27 and overall survival. Significant CpG probes were confirmed in 617 samples from The Cancer Genome Atlas. The methylation of the CpG probe cg05293407TRIM27 was significantly associated with overall survival in patients with LUSC (HR = 1.65, 95% CI: 1.30–2.09, P = 4.52 × 10−5), but not in patients with LUAD (HR = 1.08, 95% CI: 0.87–1.33, P = 0.493). As incidence of LUSC is associated with... (More)

Tripartite motif containing 27 (TRIM27) is highly expressed in lung cancer, including non-small-cell lung cancer (NSCLC). Here, we profiled DNA methylation of lung adenocarcinoma (LUAD) and lung squamous cell carcinoma (LUSC) tumours from 613 early-stage NSCLC patients and evaluated associations between CpG methylation of TRIM27 and overall survival. Significant CpG probes were confirmed in 617 samples from The Cancer Genome Atlas. The methylation of the CpG probe cg05293407TRIM27 was significantly associated with overall survival in patients with LUSC (HR = 1.65, 95% CI: 1.30–2.09, P = 4.52 × 10−5), but not in patients with LUAD (HR = 1.08, 95% CI: 0.87–1.33, P = 0.493). As incidence of LUSC is associated with higher smoking intensity compared to LUAD, we investigated whether smoking intensity impacted on the prognostic effect of cg05293407TRIM27 methylation in NSCLC. LUSC patients had a higher average pack-year of smoking (37.49LUAD vs 54.79LUSC, P = 1.03 × 10−19) and included a higher proportion of current smokers than LUAD patients (28.24%LUAD vs 34.09%LUSC, P = 0.037). cg05293407TRIM27 was significantly associated with overall survival only in NSCLC patients with medium–high pack-year of smoking (HR = 1.58, 95% CI: 1.26–1.96, P = 5.25 × 10−5). We conclude that cg05293407TRIM27 methylation is a potential predictor of LUSC prognosis, and smoking intensity may impact on its prognostic value across the various types of NSCLC.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
DNA methylation, interaction, non-small-cell lung cancer, overall survival, prognosis, TRIM27
in
Molecular Oncology
volume
14
issue
11
pages
16 pages
publisher
Elsevier
external identifiers
  • pmid:33448640
  • scopus:85090091990
ISSN
1574-7891
DOI
10.1002/1878-0261.12785
language
English
LU publication?
yes
id
487ca25d-fe41-4876-9e41-f765fbf0a438
date added to LUP
2020-09-28 09:39:28
date last changed
2024-03-05 09:40:35
@article{487ca25d-fe41-4876-9e41-f765fbf0a438,
  abstract     = {{<p>Tripartite motif containing 27 (TRIM27) is highly expressed in lung cancer, including non-small-cell lung cancer (NSCLC). Here, we profiled DNA methylation of lung adenocarcinoma (LUAD) and lung squamous cell carcinoma (LUSC) tumours from 613 early-stage NSCLC patients and evaluated associations between CpG methylation of TRIM27 and overall survival. Significant CpG probes were confirmed in 617 samples from The Cancer Genome Atlas. The methylation of the CpG probe cg05293407<sub>TRIM27</sub> was significantly associated with overall survival in patients with LUSC (HR = 1.65, 95% CI: 1.30–2.09, P = 4.52 × 10<sup>−5</sup>), but not in patients with LUAD (HR = 1.08, 95% CI: 0.87–1.33, P = 0.493). As incidence of LUSC is associated with higher smoking intensity compared to LUAD, we investigated whether smoking intensity impacted on the prognostic effect of cg05293407<sub>TRIM27</sub> methylation in NSCLC. LUSC patients had a higher average pack-year of smoking (37.49<sub>LUAD</sub> vs 54.79<sub>LUSC</sub>, P = 1.03 × 10<sup>−19</sup>) and included a higher proportion of current smokers than LUAD patients (28.24%<sub>LUAD</sub> vs 34.09%<sub>LUSC</sub>, P = 0.037). cg05293407<sub>TRIM27</sub> was significantly associated with overall survival only in NSCLC patients with medium–high pack-year of smoking (HR = 1.58, 95% CI: 1.26–1.96, P = 5.25 × 10<sup>−5</sup>). We conclude that cg05293407<sub>TRIM27</sub> methylation is a potential predictor of LUSC prognosis, and smoking intensity may impact on its prognostic value across the various types of NSCLC.</p>}},
  author       = {{Ji, Xinyu and Lin, Lijuan and Shen, Sipeng and Dong, Xuesi and Chen, Chao and Li, Yi and Zhu, Ying and Huang, Hui and Chen, Jiajin and Chen, Xin and Wei, Liangmin and He, Jieyu and Duan, Weiwei and Su, Li and Jiang, Yue and Fan, Juanjuan and Guan, Jinxing and You, Dongfang and Shafer, Andrea and Bjaanæs, Maria Moksnes and Karlsson, Anna and Planck, Maria and Staaf, Johan and Helland, Åslaug and Esteller, Manel and Wei, Yongyue and Zhang, Ruyang and Chen, Feng and Christiani, David C.}},
  issn         = {{1574-7891}},
  keywords     = {{DNA methylation; interaction; non-small-cell lung cancer; overall survival; prognosis; TRIM27}},
  language     = {{eng}},
  number       = {{11}},
  pages        = {{2759--2774}},
  publisher    = {{Elsevier}},
  series       = {{Molecular Oncology}},
  title        = {{Epigenetic–smoking interaction reveals histologically heterogeneous effects of TRIM27 DNA methylation on overall survival among early-stage NSCLC patients}},
  url          = {{http://dx.doi.org/10.1002/1878-0261.12785}},
  doi          = {{10.1002/1878-0261.12785}},
  volume       = {{14}},
  year         = {{2020}},
}