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Monkey bone matrix induces bone formation in the athymic rat, but not in adult monkeys

Aspenberg, P. LU ; Lohmander, Stefan LU orcid and Thorngren, K. G. LU (1991) In Journal of Orthopaedic Research 9(1). p.20-25
Abstract

Demineralized bone matrix from young and adult monkeys was implanted intramuscularly for 6 weeks in athymic rats and adult monkeys. Cartilage and bone induction was evaluated by histology and calcium content. In the athymic rat, most implants induced cartilage or bone. In the monkeys, cartilage was formed only on rare occasions and there was no sign of bone formation. We conclude that (a) adult monkey bone matrix contains bone inductive properties; (b) these properties are not sufficient to induce bone formation in adult monkey muscle sites.

Please use this url to cite or link to this publication:
author
; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
demineralized bone matrix, bone, Animals
in
Journal of Orthopaedic Research
volume
9
issue
1
pages
6 pages
publisher
John Wiley & Sons Inc.
external identifiers
  • pmid:1984046
  • scopus:0026026776
ISSN
0736-0266
DOI
10.1002/jor.1100090104
language
English
LU publication?
yes
id
48888eb5-30a4-4cf0-bc60-9230661f563d
date added to LUP
2016-05-04 18:18:36
date last changed
2025-01-12 01:40:35
@article{48888eb5-30a4-4cf0-bc60-9230661f563d,
  abstract     = {{<p>Demineralized bone matrix from young and adult monkeys was implanted intramuscularly for 6 weeks in athymic rats and adult monkeys. Cartilage and bone induction was evaluated by histology and calcium content. In the athymic rat, most implants induced cartilage or bone. In the monkeys, cartilage was formed only on rare occasions and there was no sign of bone formation. We conclude that (a) adult monkey bone matrix contains bone inductive properties; (b) these properties are not sufficient to induce bone formation in adult monkey muscle sites.</p>}},
  author       = {{Aspenberg, P. and Lohmander, Stefan and Thorngren, K. G.}},
  issn         = {{0736-0266}},
  keywords     = {{demineralized bone matrix; bone; Animals}},
  language     = {{eng}},
  number       = {{1}},
  pages        = {{20--25}},
  publisher    = {{John Wiley & Sons Inc.}},
  series       = {{Journal of Orthopaedic Research}},
  title        = {{Monkey bone matrix induces bone formation in the athymic rat, but not in adult monkeys}},
  url          = {{http://dx.doi.org/10.1002/jor.1100090104}},
  doi          = {{10.1002/jor.1100090104}},
  volume       = {{9}},
  year         = {{1991}},
}