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Tobacco and Alcohol in Relation to Male Breast Cancer: An Analysis of the Male Breast Cancer Pooling Project Consortium.

Cook, Michael B; Guenel, Pascal; Gapstur, Susan M; van den Brandt, Piet A; Michels, Karin B; Casagrande, John T; Cooke, Rosie; Van Den Eeden, Stephen K; Ewertz, Marianne and Falk, Roni T, et al. (2015) In Cancer Epidemiology Biomarkers & Prevention 24(3). p.520-531
Abstract
Background: The etiology of male breast cancer is poorly understood, partly due to its relative rarity. Although tobacco and alcohol exposures are known carcinogens, their association with male breast cancer risk remains ill-defined. Methods: The Male Breast Cancer Pooling Project consortium provided 2,378 cases and 51,959 controls for analysis from 10 case-control and 10 cohort studies. Individual participant data were harmonized and pooled. Unconditional logistic regression was used to estimate study design-specific (case-control/cohort) odds ratios (OR) and 95% confidence intervals (CI), which were then combined using fixed effects meta-analysis. Results: Cigarette smoking status, smoking pack-years, duration, intensity, and age at... (More)
Background: The etiology of male breast cancer is poorly understood, partly due to its relative rarity. Although tobacco and alcohol exposures are known carcinogens, their association with male breast cancer risk remains ill-defined. Methods: The Male Breast Cancer Pooling Project consortium provided 2,378 cases and 51,959 controls for analysis from 10 case-control and 10 cohort studies. Individual participant data were harmonized and pooled. Unconditional logistic regression was used to estimate study design-specific (case-control/cohort) odds ratios (OR) and 95% confidence intervals (CI), which were then combined using fixed effects meta-analysis. Results: Cigarette smoking status, smoking pack-years, duration, intensity, and age at initiation were not associated with male breast cancer risk. Relations with cigar and pipe smoking, tobacco chewing, and snuff use were also null. Recent alcohol consumption and average grams of alcohol consumed per day were also not associated with risk; only one sub-analysis of very high recent alcohol consumption (>60 grams/day) was tentatively associated with male breast cancer (ORunexposed referent=1.29, 95%CI:0.97-1.71; OR>0-<7 g/day referent=1.36, 95%CI:1.04-1.77). Specific alcoholic beverage types were not associated with male breast cancer. Relations were not altered when stratified by age or body mass index. Conclusions: In this analysis of the Male Breast Cancer Pooling Project we found little evidence that tobacco and alcohol exposures were associated with risk of male breast cancer. Impact: Tobacco and alcohol do not appear to be carcinogenic for male breast cancer. Future studies should aim to assess these exposures in relation to subtypes of male breast cancer. (Less)
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Cancer Epidemiology Biomarkers & Prevention
volume
24
issue
3
pages
520 - 531
publisher
American Association for Cancer Research
external identifiers
  • pmid:25515550
  • wos:000351953100007
  • scopus:84927719183
ISSN
1538-7755
DOI
10.1158/1055-9965.EPI-14-1009
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English
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yes
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0136352c-8069-499c-b183-91c69ecaea4a (old id 4908128)
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http://www.ncbi.nlm.nih.gov/pubmed/25515550?dopt=Abstract
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2015-01-07 16:20:33
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2017-11-19 03:08:45
@article{0136352c-8069-499c-b183-91c69ecaea4a,
  abstract     = {Background: The etiology of male breast cancer is poorly understood, partly due to its relative rarity. Although tobacco and alcohol exposures are known carcinogens, their association with male breast cancer risk remains ill-defined. Methods: The Male Breast Cancer Pooling Project consortium provided 2,378 cases and 51,959 controls for analysis from 10 case-control and 10 cohort studies. Individual participant data were harmonized and pooled. Unconditional logistic regression was used to estimate study design-specific (case-control/cohort) odds ratios (OR) and 95% confidence intervals (CI), which were then combined using fixed effects meta-analysis. Results: Cigarette smoking status, smoking pack-years, duration, intensity, and age at initiation were not associated with male breast cancer risk. Relations with cigar and pipe smoking, tobacco chewing, and snuff use were also null. Recent alcohol consumption and average grams of alcohol consumed per day were also not associated with risk; only one sub-analysis of very high recent alcohol consumption (&gt;60 grams/day) was tentatively associated with male breast cancer (ORunexposed referent=1.29, 95%CI:0.97-1.71; OR&gt;0-&lt;7 g/day referent=1.36, 95%CI:1.04-1.77). Specific alcoholic beverage types were not associated with male breast cancer. Relations were not altered when stratified by age or body mass index. Conclusions: In this analysis of the Male Breast Cancer Pooling Project we found little evidence that tobacco and alcohol exposures were associated with risk of male breast cancer. Impact: Tobacco and alcohol do not appear to be carcinogenic for male breast cancer. Future studies should aim to assess these exposures in relation to subtypes of male breast cancer.},
  author       = {Cook, Michael B and Guenel, Pascal and Gapstur, Susan M and van den Brandt, Piet A and Michels, Karin B and Casagrande, John T and Cooke, Rosie and Van Den Eeden, Stephen K and Ewertz, Marianne and Falk, Roni T and Gaudet, Mia M and Gkiokas, George and Habel, Laurel A and Hsing, Ann W and Johnson, Kenneth and Kolonel, Laurence N and La Vecchia, Carlo and Lynge, Elsebeth and Lubin, Jay H and McCormack, Valerie A and Negri, Eva and Olsson, Håkan and Parisi, Dominick and Petridou, Eleni Th and Riboli, Elio and Sesso, Howard D and Swerdlow, Anthony and Thomas, David B and Willett, Walter C and Brinton, Louise A},
  issn         = {1538-7755},
  language     = {eng},
  number       = {3},
  pages        = {520--531},
  publisher    = {American Association for Cancer Research},
  series       = {Cancer Epidemiology Biomarkers & Prevention},
  title        = {Tobacco and Alcohol in Relation to Male Breast Cancer: An Analysis of the Male Breast Cancer Pooling Project Consortium.},
  url          = {http://dx.doi.org/10.1158/1055-9965.EPI-14-1009},
  volume       = {24},
  year         = {2015},
}