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Eosinophil Cationic Protein, Carotid Plaque, and Incidence of Stroke

Sundström, Johannes ; Söderholm, Martin LU ; Borné, Yan LU ; Nilsson, Jan LU ; Persson, Margaretha LU orcid ; Östling, Gerd LU ; Melander, Olle LU orcid ; Orho-Melander, Marju LU and Engström, Gunnar LU (2017) In Stroke 48(10). p.2686-2692
Abstract

BACKGROUND AND PURPOSE: ECP (eosinophil cationic protein) is a marker of eosinophil activity and degranulation, which has been linked to atherosclerosis and cardiovascular disease. We examined the relationship between ECP, carotid plaque, and incidence of stroke in a prospective population-based cohort.

METHODS: The subjects participated in the Malmö Diet and Cancer Study between 1991 and 1994. A total of 4706 subjects with no history of stroke were included (40% men; mean age, 57.5 years). Carotid plaque was determined by B-mode ultrasound of the right carotid artery. Incidence of stroke was followed up during a mean period of 16.5 years in relation to plasma ECP levels.

RESULTS: Subjects in the third tertile (versus first... (More)

BACKGROUND AND PURPOSE: ECP (eosinophil cationic protein) is a marker of eosinophil activity and degranulation, which has been linked to atherosclerosis and cardiovascular disease. We examined the relationship between ECP, carotid plaque, and incidence of stroke in a prospective population-based cohort.

METHODS: The subjects participated in the Malmö Diet and Cancer Study between 1991 and 1994. A total of 4706 subjects with no history of stroke were included (40% men; mean age, 57.5 years). Carotid plaque was determined by B-mode ultrasound of the right carotid artery. Incidence of stroke was followed up during a mean period of 16.5 years in relation to plasma ECP levels.

RESULTS: Subjects in the third tertile (versus first tertile) of ECP tended to have higher prevalence of carotid plaque (odds ratio: 1.18; 95% confidence interval: 1.003-1.39; P=0.044 after multivariate adjustments). A total of 258 subjects were diagnosed with ischemic stroke (IS) during follow-up. ECP was associated with increased incidence of IS after risk factor adjustment (hazard ratio, 1.57; 95% confidence interval: 1.13-2.18; for third versus first tertile; P=0.007). High ECP was associated with increased risk of IS in subjects with carotid plaque. The risk factor-adjusted hazard ratio for IS was 1.86 (95% confidence interval: 1.32-2.63) in subjects with carotid plaque and ECP in the top tertile, compared with those without plaque and ECP in the first or second tertiles.

CONCLUSIONS: High ECP is associated with increased incidence of IS. The association between ECP and IS was also present in the subgroup with carotid plaque.

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author
; ; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
cohort studies, eosinophil cationic protein, epidemiology, risk factors, stroke
in
Stroke
volume
48
issue
10
pages
7 pages
publisher
American Heart Association
external identifiers
  • scopus:85030995981
  • pmid:28904229
  • wos:000411572500030
ISSN
1524-4628
DOI
10.1161/STROKEAHA.117.018450
language
English
LU publication?
yes
id
4928e124-d423-45c4-a483-cb2321ecb094
date added to LUP
2017-11-07 09:19:40
date last changed
2025-10-14 13:19:22
@article{4928e124-d423-45c4-a483-cb2321ecb094,
  abstract     = {{<p>BACKGROUND AND PURPOSE: ECP (eosinophil cationic protein) is a marker of eosinophil activity and degranulation, which has been linked to atherosclerosis and cardiovascular disease. We examined the relationship between ECP, carotid plaque, and incidence of stroke in a prospective population-based cohort.</p><p>METHODS: The subjects participated in the Malmö Diet and Cancer Study between 1991 and 1994. A total of 4706 subjects with no history of stroke were included (40% men; mean age, 57.5 years). Carotid plaque was determined by B-mode ultrasound of the right carotid artery. Incidence of stroke was followed up during a mean period of 16.5 years in relation to plasma ECP levels.</p><p>RESULTS: Subjects in the third tertile (versus first tertile) of ECP tended to have higher prevalence of carotid plaque (odds ratio: 1.18; 95% confidence interval: 1.003-1.39; P=0.044 after multivariate adjustments). A total of 258 subjects were diagnosed with ischemic stroke (IS) during follow-up. ECP was associated with increased incidence of IS after risk factor adjustment (hazard ratio, 1.57; 95% confidence interval: 1.13-2.18; for third versus first tertile; P=0.007). High ECP was associated with increased risk of IS in subjects with carotid plaque. The risk factor-adjusted hazard ratio for IS was 1.86 (95% confidence interval: 1.32-2.63) in subjects with carotid plaque and ECP in the top tertile, compared with those without plaque and ECP in the first or second tertiles.</p><p>CONCLUSIONS: High ECP is associated with increased incidence of IS. The association between ECP and IS was also present in the subgroup with carotid plaque.</p>}},
  author       = {{Sundström, Johannes and Söderholm, Martin and Borné, Yan and Nilsson, Jan and Persson, Margaretha and Östling, Gerd and Melander, Olle and Orho-Melander, Marju and Engström, Gunnar}},
  issn         = {{1524-4628}},
  keywords     = {{cohort studies; eosinophil cationic protein; epidemiology; risk factors; stroke}},
  language     = {{eng}},
  month        = {{10}},
  number       = {{10}},
  pages        = {{2686--2692}},
  publisher    = {{American Heart Association}},
  series       = {{Stroke}},
  title        = {{Eosinophil Cationic Protein, Carotid Plaque, and Incidence of Stroke}},
  url          = {{http://dx.doi.org/10.1161/STROKEAHA.117.018450}},
  doi          = {{10.1161/STROKEAHA.117.018450}},
  volume       = {{48}},
  year         = {{2017}},
}