Lung deposition of surfactant delivered via a dedicated laryngeal mask airway in piglets
(2021) In Pharmaceutics 13(11).- Abstract
It is unknown if the lung deposition of surfactant administered via a catheter placed through a laryngeal mask airway (LMA) is equivalent to that obtained by bolus instillation through an endotracheal tube. We compare the lung deposition of surfactant delivered via two types of LMA with the standard technique of endotracheal instillation. 25 newborn piglets on continuous positive airway pressure support (CPAP) were randomized into three groups: 1—LMA-camera (integrated camera and catheter channel; catheter tip below vocal cords), 2—LMA-standard (no camera, no channel; catheter tip above the glottis), 3—InSurE (Intubation, Surfactant administration, Extubation; catheter tip below end of endotracheal tube). All animals received 100... (More)
It is unknown if the lung deposition of surfactant administered via a catheter placed through a laryngeal mask airway (LMA) is equivalent to that obtained by bolus instillation through an endotracheal tube. We compare the lung deposition of surfactant delivered via two types of LMA with the standard technique of endotracheal instillation. 25 newborn piglets on continuous positive airway pressure support (CPAP) were randomized into three groups: 1—LMA-camera (integrated camera and catheter channel; catheter tip below vocal cords), 2—LMA-standard (no camera, no channel; catheter tip above the glottis), 3—InSurE (Intubation, Surfactant administration, Extubation; catheter tip below end of endotracheal tube). All animals received 100 mg·kg−1 of poractant alfa mixed with99mTechnetium-nanocolloid. Surfactant deposition was measured by gamma scintigraphy as a percentage of the administered dose. The median (range) total lung surfactant deposition was 68% (10–85), 41% (5–88), and 88% (67–92) in LMA-camera, LMA-standard, and InSurE, respectively, which was higher (p < 0.05) in the latter. The deposition in the stomach and nasopharynx was higher with the LMA-standard. The surfactant deposition via an LMA was lower than that obtained with InSurE. Although not statistically significant, introducing the catheter below the vocal cords under visual control with an integrated camera improved surfactant LMA delivery by 65%.
(Less)
- author
- Nord, Anders LU ; Cunha-Goncalves, Doris LU ; Linnér, Rikard LU ; Bianco, Federico ; Salomone, Fabrizio ; Ricci, Francesca ; Lombardini, Marta ; Micaglio, Massimo ; Trevisanuto, Daniele and Perez-De-sa, Valeria LU
- organization
- publishing date
- 2021-11
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Laryngeal mask airway, Lung deposition, Newborn, Scintigraphy, Surfactant
- in
- Pharmaceutics
- volume
- 13
- issue
- 11
- article number
- 1858
- publisher
- MDPI AG
- external identifiers
-
- scopus:85118760054
- pmid:34834273
- ISSN
- 1999-4923
- DOI
- 10.3390/pharmaceutics13111858
- language
- English
- LU publication?
- yes
- additional info
- Publisher Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland.
- id
- 494376d4-50fd-4d6d-95f1-92b37a1e12f3
- date added to LUP
- 2021-12-03 14:34:14
- date last changed
- 2024-09-22 07:06:58
@article{494376d4-50fd-4d6d-95f1-92b37a1e12f3, abstract = {{<p>It is unknown if the lung deposition of surfactant administered via a catheter placed through a laryngeal mask airway (LMA) is equivalent to that obtained by bolus instillation through an endotracheal tube. We compare the lung deposition of surfactant delivered via two types of LMA with the standard technique of endotracheal instillation. 25 newborn piglets on continuous positive airway pressure support (CPAP) were randomized into three groups: 1—LMA-camera (integrated camera and catheter channel; catheter tip below vocal cords), 2—LMA-standard (no camera, no channel; catheter tip above the glottis), 3—InSurE (Intubation, Surfactant administration, Extubation; catheter tip below end of endotracheal tube). All animals received 100 mg·kg<sup>−1</sup> of poractant alfa mixed with<sup>99m</sup>Technetium-nanocolloid. Surfactant deposition was measured by gamma scintigraphy as a percentage of the administered dose. The median (range) total lung surfactant deposition was 68% (10–85), 41% (5–88), and 88% (67–92) in LMA-camera, LMA-standard, and InSurE, respectively, which was higher (p < 0.05) in the latter. The deposition in the stomach and nasopharynx was higher with the LMA-standard. The surfactant deposition via an LMA was lower than that obtained with InSurE. Although not statistically significant, introducing the catheter below the vocal cords under visual control with an integrated camera improved surfactant LMA delivery by 65%.</p>}}, author = {{Nord, Anders and Cunha-Goncalves, Doris and Linnér, Rikard and Bianco, Federico and Salomone, Fabrizio and Ricci, Francesca and Lombardini, Marta and Micaglio, Massimo and Trevisanuto, Daniele and Perez-De-sa, Valeria}}, issn = {{1999-4923}}, keywords = {{Laryngeal mask airway; Lung deposition; Newborn; Scintigraphy; Surfactant}}, language = {{eng}}, number = {{11}}, publisher = {{MDPI AG}}, series = {{Pharmaceutics}}, title = {{Lung deposition of surfactant delivered via a dedicated laryngeal mask airway in piglets}}, url = {{http://dx.doi.org/10.3390/pharmaceutics13111858}}, doi = {{10.3390/pharmaceutics13111858}}, volume = {{13}}, year = {{2021}}, }