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Xenotransplantation for CNS repair : immunological barriers and strategies to overcome them

Brevig, T; Holgersson, J. and Widner, Håkan LU (2000) In Trends in Neurosciences 23(8). p.44-337
Abstract

Neural transplantation holds promise for focal CNS repair. Owing to the shortage of human donor material, which is derived from aborted embryos, and ethical concerns over its use, animal donor tissue is now considered an appropriate alternative. In the USA, individuals suffering from Parkinson's disease, Huntington's disease, focal epilepsy or stroke have already received neural grafts from pig embryos. However, in animal models, neural tissue transplanted between species is usually promptly rejected, even when implanted in the brain. Some of the immunological mechanisms that underlie neural xenograft rejection have recently been elucidated, but others remain to be determined and controlled before individuals with neurological disorders... (More)

Neural transplantation holds promise for focal CNS repair. Owing to the shortage of human donor material, which is derived from aborted embryos, and ethical concerns over its use, animal donor tissue is now considered an appropriate alternative. In the USA, individuals suffering from Parkinson's disease, Huntington's disease, focal epilepsy or stroke have already received neural grafts from pig embryos. However, in animal models, neural tissue transplanted between species is usually promptly rejected, even when implanted in the brain. Some of the immunological mechanisms that underlie neural xenograft rejection have recently been elucidated, but others remain to be determined and controlled before individuals with neurological disorders can benefit from xenotransplantation.

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author
organization
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type
Contribution to journal
publication status
published
subject
keywords
Animals, Brain Tissue Transplantation, Central Nervous System, Humans, Transplantation, Heterologous, Journal Article, Review
in
Trends in Neurosciences
volume
23
issue
8
pages
8 pages
publisher
Elsevier
external identifiers
  • scopus:0034255153
ISSN
0166-2236
DOI
10.1016/S0166-2236(00)01605-2
language
English
LU publication?
yes
id
495d3846-5ea9-4054-85d5-fb4f7eea0c77
date added to LUP
2017-04-19 18:20:22
date last changed
2017-07-30 05:24:11
@article{495d3846-5ea9-4054-85d5-fb4f7eea0c77,
  abstract     = {<p>Neural transplantation holds promise for focal CNS repair. Owing to the shortage of human donor material, which is derived from aborted embryos, and ethical concerns over its use, animal donor tissue is now considered an appropriate alternative. In the USA, individuals suffering from Parkinson's disease, Huntington's disease, focal epilepsy or stroke have already received neural grafts from pig embryos. However, in animal models, neural tissue transplanted between species is usually promptly rejected, even when implanted in the brain. Some of the immunological mechanisms that underlie neural xenograft rejection have recently been elucidated, but others remain to be determined and controlled before individuals with neurological disorders can benefit from xenotransplantation.</p>},
  author       = {Brevig, T and Holgersson, J. and Widner, Håkan},
  issn         = {0166-2236},
  keyword      = {Animals,Brain Tissue Transplantation,Central Nervous System,Humans,Transplantation, Heterologous,Journal Article,Review},
  language     = {eng},
  number       = {8},
  pages        = {44--337},
  publisher    = {Elsevier},
  series       = {Trends in Neurosciences},
  title        = {Xenotransplantation for CNS repair : immunological barriers and strategies to overcome them},
  url          = {http://dx.doi.org/10.1016/S0166-2236(00)01605-2},
  volume       = {23},
  year         = {2000},
}