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How Might Novel Technologies Such as Optogenetics Lead to Better Treatments in Epilepsy?

Krook-Magnuson, Esther ; Ledri, Marco LU ; Soltesz, Ivan and Kokaia, Merab LU (2014) In Advances in Experimental Medicine and Biology 813. p.319-336
Abstract
Recent technological advances open exciting avenues for improving the understanding of mechanisms in a broad range of epilepsies. This chapter focuses on the development of optogenetics and on-demand technologies for the study of epilepsy and the control of seizures. Optogenetics is a technique which, through cell-type selective expression of light-sensitive proteins called opsins, allows temporally precise control via light delivery of specific populations of neurons. Therefore, it is now possible not only to record interictal and ictal neuronal activity, but also to test causality and identify potential new therapeutic approaches. We first discuss the benefits and caveats to using optogenetic approaches and recent advances in... (More)
Recent technological advances open exciting avenues for improving the understanding of mechanisms in a broad range of epilepsies. This chapter focuses on the development of optogenetics and on-demand technologies for the study of epilepsy and the control of seizures. Optogenetics is a technique which, through cell-type selective expression of light-sensitive proteins called opsins, allows temporally precise control via light delivery of specific populations of neurons. Therefore, it is now possible not only to record interictal and ictal neuronal activity, but also to test causality and identify potential new therapeutic approaches. We first discuss the benefits and caveats to using optogenetic approaches and recent advances in optogenetics related tools. We then turn to the use of optogenetics, including on-demand optogenetics in the study of epilepsies, which highlights the powerful potential of optogenetics for epilepsy research. (Less)
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author
; ; and
organization
publishing date
type
Chapter in Book/Report/Conference proceeding
publication status
published
subject
keywords
On-demand, Responsive, Channelrhodopsin, Halorhodopsin, Arch, AAV, Optrode, Seizure
host publication
Issues in Clinical Epileptology: A View From the Bench
series title
Advances in Experimental Medicine and Biology
editor
Scharfman, Helen E. and Buckmaster, Paul S.
volume
813
pages
319 - 336
publisher
Springer
external identifiers
  • wos:000346021700028
  • pmid:25012388
  • scopus:84934444701
ISSN
0065-2598
ISBN
978-94-017-8914-1
DOI
10.1007/978-94-017-8914-1_26
language
English
LU publication?
yes
id
218e2095-0a68-4597-a670-a83c11a58baa (old id 4962505)
date added to LUP
2016-04-01 13:06:17
date last changed
2021-09-01 05:41:42
@inbook{218e2095-0a68-4597-a670-a83c11a58baa,
  abstract     = {Recent technological advances open exciting avenues for improving the understanding of mechanisms in a broad range of epilepsies. This chapter focuses on the development of optogenetics and on-demand technologies for the study of epilepsy and the control of seizures. Optogenetics is a technique which, through cell-type selective expression of light-sensitive proteins called opsins, allows temporally precise control via light delivery of specific populations of neurons. Therefore, it is now possible not only to record interictal and ictal neuronal activity, but also to test causality and identify potential new therapeutic approaches. We first discuss the benefits and caveats to using optogenetic approaches and recent advances in optogenetics related tools. We then turn to the use of optogenetics, including on-demand optogenetics in the study of epilepsies, which highlights the powerful potential of optogenetics for epilepsy research.},
  author       = {Krook-Magnuson, Esther and Ledri, Marco and Soltesz, Ivan and Kokaia, Merab},
  booktitle    = {Issues in Clinical Epileptology: A View From the Bench},
  editor       = {Scharfman, Helen E. and Buckmaster, Paul S.},
  isbn         = {978-94-017-8914-1},
  issn         = {0065-2598},
  language     = {eng},
  pages        = {319--336},
  publisher    = {Springer},
  series       = {Advances in Experimental Medicine and Biology},
  title        = {How Might Novel Technologies Such as Optogenetics Lead to Better Treatments in Epilepsy?},
  url          = {http://dx.doi.org/10.1007/978-94-017-8914-1_26},
  doi          = {10.1007/978-94-017-8914-1_26},
  volume       = {813},
  year         = {2014},
}