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SOCS6 is a selective suppressor of receptor tyrosine kinase signaling

Kabir, Nuzhat N.; Sun, Jianmin LU ; Rönnstrand, Lars LU and Kazi, Julhash U. LU (2014) In Tumor Biology 35(11). p.10581-10589
Abstract
The suppressors of cytokine signaling (SOCS) are well-known negative regulators of cytokine receptor signaling. SOCS6 is one of eight members of the SOCS family of proteins. Similar to other SOCS proteins, SOCS6 consists of an uncharacterized extended N-terminal region followed by an SH2 domain and a SOCS box. Unlike other SOCS proteins, SOCS6 is mainly involved in negative regulation of receptor tyrosine kinase signaling. SOCS6 is widely expressed in many tissues and is found to be downregulated in many cancers including colorectal cancer, gastric cancer, lung cancer, ovarian cancer, stomach cancer, thyroid cancer, hepatocellular carcinoma, and pancreatic cancer. SOCS6 is involved in negative regulation of receptor signaling by increasing... (More)
The suppressors of cytokine signaling (SOCS) are well-known negative regulators of cytokine receptor signaling. SOCS6 is one of eight members of the SOCS family of proteins. Similar to other SOCS proteins, SOCS6 consists of an uncharacterized extended N-terminal region followed by an SH2 domain and a SOCS box. Unlike other SOCS proteins, SOCS6 is mainly involved in negative regulation of receptor tyrosine kinase signaling. SOCS6 is widely expressed in many tissues and is found to be downregulated in many cancers including colorectal cancer, gastric cancer, lung cancer, ovarian cancer, stomach cancer, thyroid cancer, hepatocellular carcinoma, and pancreatic cancer. SOCS6 is involved in negative regulation of receptor signaling by increasing degradation mediated by ubiquitination of receptors or substrate proteins and induces apoptosis by targeting mitochondrial proteins. Therefore, SOCS6 turns out as an important regulator of survival signaling and its activity is required for controlling receptor tyrosine kinase signaling. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
SOCS, FLT3, KIT, INSR, SCF, Insulin, FL
in
Tumor Biology
volume
35
issue
11
pages
10581 - 10589
publisher
Springer
external identifiers
  • wos:000345413100001
  • scopus:84920938375
ISSN
1423-0380
DOI
10.1007/s13277-014-2542-4
language
English
LU publication?
yes
id
4691ac2a-0299-422b-964b-6828ecc5f17d (old id 4979644)
date added to LUP
2015-02-03 07:09:59
date last changed
2017-11-19 03:51:47
@article{4691ac2a-0299-422b-964b-6828ecc5f17d,
  abstract     = {The suppressors of cytokine signaling (SOCS) are well-known negative regulators of cytokine receptor signaling. SOCS6 is one of eight members of the SOCS family of proteins. Similar to other SOCS proteins, SOCS6 consists of an uncharacterized extended N-terminal region followed by an SH2 domain and a SOCS box. Unlike other SOCS proteins, SOCS6 is mainly involved in negative regulation of receptor tyrosine kinase signaling. SOCS6 is widely expressed in many tissues and is found to be downregulated in many cancers including colorectal cancer, gastric cancer, lung cancer, ovarian cancer, stomach cancer, thyroid cancer, hepatocellular carcinoma, and pancreatic cancer. SOCS6 is involved in negative regulation of receptor signaling by increasing degradation mediated by ubiquitination of receptors or substrate proteins and induces apoptosis by targeting mitochondrial proteins. Therefore, SOCS6 turns out as an important regulator of survival signaling and its activity is required for controlling receptor tyrosine kinase signaling.},
  author       = {Kabir, Nuzhat N. and Sun, Jianmin and Rönnstrand, Lars and Kazi, Julhash U.},
  issn         = {1423-0380},
  keyword      = {SOCS,FLT3,KIT,INSR,SCF,Insulin,FL},
  language     = {eng},
  number       = {11},
  pages        = {10581--10589},
  publisher    = {Springer},
  series       = {Tumor Biology},
  title        = {SOCS6 is a selective suppressor of receptor tyrosine kinase signaling},
  url          = {http://dx.doi.org/10.1007/s13277-014-2542-4},
  volume       = {35},
  year         = {2014},
}