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Alcohol Consumption and Survival after a Breast Cancer Diagnosis: A Literature-Based Meta-analysis and Collaborative Analysis of Data for 29,239 Cases

Ali, Alaa M. G.; Schmidt, Marjanka K.; Bolla, Manjeet K.; Wang, Qin; Gago-Dominguez, M.; Esteban Castelao, J.; Carracedo, Angel; Munoz Garzon, Victor; Bojesen, Stig E. and Nordestgaard, Borge G., et al. (2014) In Cancer Epidemiology Biomarkers & Prevention 23(6). p.934-945
Abstract
Background: Evidence for an association of alcohol consumption with prognosis after a diagnosis of breast cancer has been inconsistent. We have reviewed and summarized the published evidence and evaluated the association using individual patient data from multiple case cohorts. Methods: A MEDLINE search to identify studies published up to January 2013 was performed. We combined published estimates of survival time for "moderate drinkers" versus nondrinkers. An analysis of individual participant data using Cox regression was carried out using data from 11 case cohorts. Results: We identified 11 published studies suitable for inclusion in the meta-analysis. Moderate postdiagnosis alcohol consumption was not associated with overall survival... (More)
Background: Evidence for an association of alcohol consumption with prognosis after a diagnosis of breast cancer has been inconsistent. We have reviewed and summarized the published evidence and evaluated the association using individual patient data from multiple case cohorts. Methods: A MEDLINE search to identify studies published up to January 2013 was performed. We combined published estimates of survival time for "moderate drinkers" versus nondrinkers. An analysis of individual participant data using Cox regression was carried out using data from 11 case cohorts. Results: We identified 11 published studies suitable for inclusion in the meta-analysis. Moderate postdiagnosis alcohol consumption was not associated with overall survival [HR, 0.95; 95% confidence interval (CI), 0.85-1.05], but there was some evidence of better survival associated with prediagnosis consumption (HR, 0.80; 95% CI, 0.73-0.88). Individual data on alcohol consumption for 29,239 cases with 4,839 deaths were available from the 11 case cohorts, all of which had data on estrogen receptor (ER) status. For women with ER-positive disease, there was little evidence that pre-or postdiagnosis alcohol consumption is associated with breast cancer-specific mortality, with some evidence of a negative association with all-cause mortality. On the basis of a single study, moderate postdiagnosis alcohol intake was associated with a small reduction in breast cancer-specific mortality for women with ER-negative disease. There was no association with prediagnosis intake for women with ER-negative disease. Conclusion: There was little evidence that pre- or post-diagnosis alcohol consumption is associated with breast cancer-specific mortality for women with ER-positive disease. There was weak evidence that moderate post-diagnosis alcohol intake is associated with a small reduction in breast cancer-specific mortality in ER-negative disease. Impact: Considering the totality of the evidence, moderate postdiagnosis alcohol consumption is unlikely to have a major adverse effect on the survival of women with breast cancer. (C) 2014 AACR. (Less)
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published
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Cancer Epidemiology Biomarkers & Prevention
volume
23
issue
6
pages
934 - 945
publisher
American Association for Cancer Research
external identifiers
  • wos:000345270800005
  • scopus:84903381193
ISSN
1538-7755
DOI
10.1158/1055-9965.EPI-13-0901
language
English
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yes
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4179cc51-5ed8-40f8-81d8-9b7f3602c0b9 (old id 4985682)
date added to LUP
2015-02-03 07:17:31
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2017-10-01 04:12:33
@article{4179cc51-5ed8-40f8-81d8-9b7f3602c0b9,
  abstract     = {Background: Evidence for an association of alcohol consumption with prognosis after a diagnosis of breast cancer has been inconsistent. We have reviewed and summarized the published evidence and evaluated the association using individual patient data from multiple case cohorts. Methods: A MEDLINE search to identify studies published up to January 2013 was performed. We combined published estimates of survival time for "moderate drinkers" versus nondrinkers. An analysis of individual participant data using Cox regression was carried out using data from 11 case cohorts. Results: We identified 11 published studies suitable for inclusion in the meta-analysis. Moderate postdiagnosis alcohol consumption was not associated with overall survival [HR, 0.95; 95% confidence interval (CI), 0.85-1.05], but there was some evidence of better survival associated with prediagnosis consumption (HR, 0.80; 95% CI, 0.73-0.88). Individual data on alcohol consumption for 29,239 cases with 4,839 deaths were available from the 11 case cohorts, all of which had data on estrogen receptor (ER) status. For women with ER-positive disease, there was little evidence that pre-or postdiagnosis alcohol consumption is associated with breast cancer-specific mortality, with some evidence of a negative association with all-cause mortality. On the basis of a single study, moderate postdiagnosis alcohol intake was associated with a small reduction in breast cancer-specific mortality for women with ER-negative disease. There was no association with prediagnosis intake for women with ER-negative disease. Conclusion: There was little evidence that pre- or post-diagnosis alcohol consumption is associated with breast cancer-specific mortality for women with ER-positive disease. There was weak evidence that moderate post-diagnosis alcohol intake is associated with a small reduction in breast cancer-specific mortality in ER-negative disease. Impact: Considering the totality of the evidence, moderate postdiagnosis alcohol consumption is unlikely to have a major adverse effect on the survival of women with breast cancer. (C) 2014 AACR.},
  author       = {Ali, Alaa M. G. and Schmidt, Marjanka K. and Bolla, Manjeet K. and Wang, Qin and Gago-Dominguez, M. and Esteban Castelao, J. and Carracedo, Angel and Munoz Garzon, Victor and Bojesen, Stig E. and Nordestgaard, Borge G. and Flyger, Henrik and Chang-Claude, Jenny and Vrieling, Alina and Rudolph, Anja and Seibold, Petra and Nevanlinna, Heli and Muranen, Taru A. and Aaltonen, Kirsimari and Blomqvist, Carl and Matsuo, Keitaro and Ito, Hidemi and Iwata, Hiroji and Horio, Akiyo and John, Esther M. and Sherman, Mark and Lissowska, Jolanta and Figueroa, Jonine and Garcia-Closas, Montserrat and Anton-Culver, Hoda and Shah, Mitul and Hopper, John L. and Trichopoulou, Antonia and Bueno-de-Mesquita, Bas and Krogh, Vittorio and Weiderpass, Elisabete and Andersson, Anne and Clavel-Chapelon, Francoise and Dossus, Laure and Fagherazzi, Guy and Peeters, Petra H. and Olsen, Anja and Wishart, Gordon C. and Easton, Douglas F. and Borgquist, Signe and Overvad, Kim and Barricarte, Aurelio and Gonzalez, Carlos A. and Sanchez, Maria-Jose and Amiano, Pilar and Riboli, Elio and Key, Tim and Pharoah, Paul D.},
  issn         = {1538-7755},
  language     = {eng},
  number       = {6},
  pages        = {934--945},
  publisher    = {American Association for Cancer Research},
  series       = {Cancer Epidemiology Biomarkers & Prevention},
  title        = {Alcohol Consumption and Survival after a Breast Cancer Diagnosis: A Literature-Based Meta-analysis and Collaborative Analysis of Data for 29,239 Cases},
  url          = {http://dx.doi.org/10.1158/1055-9965.EPI-13-0901},
  volume       = {23},
  year         = {2014},
}