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Modelling human rostro-caudal neural patterning with a microfluidic morphogenic gradient

Isaksson, Marc LU ; Rifes, Pedro LU ; Laurell, Thomas LU and Kirkeby, Agnete LU (2017) 21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017 In MicroTAS 2017. p.147-148
Abstract

The study of biological mechanisms involved in human fetal brain development requires suitable models. To date, most findings have been acquired from animal models that fail to account for human-specific developmental traits. To counteract this limitation, a novel in vitro model is proposed where human pluripotent stem cells are differentiated into a coherent fetal brain tissue in a gradient forming microfluidic system. Stainings show that the model can be used to investigate the patterning, an important developmental event, of stem cells into forebrain, midbrain and hindbrain. In conclusion, this model could provide a new platform for studying human-specific brain development.

Please use this url to cite or link to this publication:
author
; ; and
organization
publishing date
type
Chapter in Book/Report/Conference proceeding
publication status
published
subject
keywords
Human neural development, Microfluidics
host publication
MicroTAS 2017 : Savannah, Georgia, USA - Savannah, Georgia, USA
series title
MicroTAS
volume
2017
pages
2 pages
publisher
Chemical and Biological Microsystems Society
conference name
21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017
conference location
Savannah, United States
conference dates
2017-10-22 - 2017-10-26
external identifiers
  • scopus:85079690593
ISSN
1556-5904
ISBN
9780692941836
language
English
LU publication?
yes
id
4a254058-b1b9-4c5b-a783-cc476e59ebbe
date added to LUP
2020-03-05 10:55:44
date last changed
2023-09-24 00:59:11
@inproceedings{4a254058-b1b9-4c5b-a783-cc476e59ebbe,
  abstract     = {{<p>The study of biological mechanisms involved in human fetal brain development requires suitable models. To date, most findings have been acquired from animal models that fail to account for human-specific developmental traits. To counteract this limitation, a novel in vitro model is proposed where human pluripotent stem cells are differentiated into a coherent fetal brain tissue in a gradient forming microfluidic system. Stainings show that the model can be used to investigate the patterning, an important developmental event, of stem cells into forebrain, midbrain and hindbrain. In conclusion, this model could provide a new platform for studying human-specific brain development.</p>}},
  author       = {{Isaksson, Marc and Rifes, Pedro and Laurell, Thomas and Kirkeby, Agnete}},
  booktitle    = {{MicroTAS 2017 : Savannah, Georgia, USA}},
  isbn         = {{9780692941836}},
  issn         = {{1556-5904}},
  keywords     = {{Human neural development; Microfluidics}},
  language     = {{eng}},
  pages        = {{147--148}},
  publisher    = {{Chemical and Biological Microsystems Society}},
  series       = {{MicroTAS}},
  title        = {{Modelling human rostro-caudal neural patterning with a microfluidic morphogenic gradient}},
  volume       = {{2017}},
  year         = {{2017}},
}