Modelling human rostro-caudal neural patterning with a microfluidic morphogenic gradient
(2017) 21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017 In MicroTAS 2017. p.147-148- Abstract
The study of biological mechanisms involved in human fetal brain development requires suitable models. To date, most findings have been acquired from animal models that fail to account for human-specific developmental traits. To counteract this limitation, a novel in vitro model is proposed where human pluripotent stem cells are differentiated into a coherent fetal brain tissue in a gradient forming microfluidic system. Stainings show that the model can be used to investigate the patterning, an important developmental event, of stem cells into forebrain, midbrain and hindbrain. In conclusion, this model could provide a new platform for studying human-specific brain development.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/4a254058-b1b9-4c5b-a783-cc476e59ebbe
- author
- Isaksson, Marc LU ; Rifes, Pedro LU ; Laurell, Thomas LU and Kirkeby, Agnete LU
- organization
-
- MultiPark: Multidisciplinary research focused on ParkinsonĀ“s disease
- Department of Biomedical Engineering
- Wallenberg Neuroscience Centre, Lund
- Human Neural Developmental Biology (research group)
- NanoLund: Centre for Nanoscience
- BioCARE: Biomarkers in Cancer Medicine improving Health Care, Education and Innovation
- publishing date
- 2017
- type
- Chapter in Book/Report/Conference proceeding
- publication status
- published
- subject
- keywords
- Human neural development, Microfluidics
- host publication
- MicroTAS 2017 : Savannah, Georgia, USA - Savannah, Georgia, USA
- series title
- MicroTAS
- volume
- 2017
- pages
- 2 pages
- publisher
- Chemical and Biological Microsystems Society
- conference name
- 21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017
- conference location
- Savannah, United States
- conference dates
- 2017-10-22 - 2017-10-26
- external identifiers
-
- scopus:85079690593
- ISSN
- 1556-5904
- ISBN
- 9780692941836
- language
- English
- LU publication?
- yes
- id
- 4a254058-b1b9-4c5b-a783-cc476e59ebbe
- date added to LUP
- 2020-03-05 10:55:44
- date last changed
- 2023-09-24 00:59:11
@inproceedings{4a254058-b1b9-4c5b-a783-cc476e59ebbe, abstract = {{<p>The study of biological mechanisms involved in human fetal brain development requires suitable models. To date, most findings have been acquired from animal models that fail to account for human-specific developmental traits. To counteract this limitation, a novel in vitro model is proposed where human pluripotent stem cells are differentiated into a coherent fetal brain tissue in a gradient forming microfluidic system. Stainings show that the model can be used to investigate the patterning, an important developmental event, of stem cells into forebrain, midbrain and hindbrain. In conclusion, this model could provide a new platform for studying human-specific brain development.</p>}}, author = {{Isaksson, Marc and Rifes, Pedro and Laurell, Thomas and Kirkeby, Agnete}}, booktitle = {{MicroTAS 2017 : Savannah, Georgia, USA}}, isbn = {{9780692941836}}, issn = {{1556-5904}}, keywords = {{Human neural development; Microfluidics}}, language = {{eng}}, pages = {{147--148}}, publisher = {{Chemical and Biological Microsystems Society}}, series = {{MicroTAS}}, title = {{Modelling human rostro-caudal neural patterning with a microfluidic morphogenic gradient}}, volume = {{2017}}, year = {{2017}}, }