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Beneficial effects of spermidine on cardiovascular health and longevity suggest a cell type-specific import of polyamines by cardiomyocytes

Nilsson, Bengt Olof LU and Persson, Lo LU (2018) In Biochemical Society Transactions 47(1). p.265-272
Abstract

Recent and exciting in vivo studies show that supplementation with the polyamine spermidine (Spd) is cardioprotective and prolongs lifespan in both mice and humans. The mechanisms behind Spd-induced cardioprotection are supposed to involve Spd-evoked stimulation of autophagy, mitophagy and mitochondrial respiration and improved the mechano-elastical function of cardiomyocytes. Although cellular uptake of Spd was not characterized, these results suggest that Spd is imported by the cardiomyocytes and acts intracellularly. In the light of these new and thrilling data, we discuss in the present review cellular polyamine import with a special focus on mechanisms that may be relevant for Spd uptake by electrically excitable cells such as... (More)

Recent and exciting in vivo studies show that supplementation with the polyamine spermidine (Spd) is cardioprotective and prolongs lifespan in both mice and humans. The mechanisms behind Spd-induced cardioprotection are supposed to involve Spd-evoked stimulation of autophagy, mitophagy and mitochondrial respiration and improved the mechano-elastical function of cardiomyocytes. Although cellular uptake of Spd was not characterized, these results suggest that Spd is imported by the cardiomyocytes and acts intracellularly. In the light of these new and thrilling data, we discuss in the present review cellular polyamine import with a special focus on mechanisms that may be relevant for Spd uptake by electrically excitable cells such as cardiomyocytes.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Biochemical Society Transactions
volume
47
issue
1
pages
8 pages
publisher
Biochemical Society
external identifiers
  • scopus:85062504381
ISSN
0300-5127
DOI
10.1042/BST20180622
language
English
LU publication?
yes
id
4a446d8b-17b1-4e9e-8ffd-2fb7c369e9b7
date added to LUP
2019-03-19 09:08:20
date last changed
2019-04-10 04:21:21
@article{4a446d8b-17b1-4e9e-8ffd-2fb7c369e9b7,
  abstract     = {<p>Recent and exciting in vivo studies show that supplementation with the polyamine spermidine (Spd) is cardioprotective and prolongs lifespan in both mice and humans. The mechanisms behind Spd-induced cardioprotection are supposed to involve Spd-evoked stimulation of autophagy, mitophagy and mitochondrial respiration and improved the mechano-elastical function of cardiomyocytes. Although cellular uptake of Spd was not characterized, these results suggest that Spd is imported by the cardiomyocytes and acts intracellularly. In the light of these new and thrilling data, we discuss in the present review cellular polyamine import with a special focus on mechanisms that may be relevant for Spd uptake by electrically excitable cells such as cardiomyocytes.</p>},
  author       = {Nilsson, Bengt Olof and Persson, Lo},
  issn         = {0300-5127},
  language     = {eng},
  number       = {1},
  pages        = {265--272},
  publisher    = {Biochemical Society},
  series       = {Biochemical Society Transactions},
  title        = {Beneficial effects of spermidine on cardiovascular health and longevity suggest a cell type-specific import of polyamines by cardiomyocytes},
  url          = {http://dx.doi.org/10.1042/BST20180622},
  volume       = {47},
  year         = {2018},
}