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Generation of a human induced pluripotent stem cell line (CSC-42) from a patient with sporadic form of Parkinson's disease

Savchenko, Ekaterina LU ; Marote, Ana LU ; Russ, Kaspar LU ; Collin, Anna LU ; Goldwurm, Stefano; Roybon, Laurent LU and Pomeshchik, Yuriy LU (2018) In Stem Cell Research 27. p.78-81
Abstract

Skin fibroblasts were collected from a 44-year-old patient with sporadic case of Parkinson's disease (PD). The non-integrating Sendai virus vector encoding OCT3/4, SOX2, c-MYC and KLF4 was used to reprogram fibroblasts into induced pluripotent stem cells (iPSCs). Generated iPSCs had normal karyotypes, expressed common stem cell markers, and were capable of differentiating into all three germ layers. Generated line could be used for PD modeling to understand the mechanisms that influence the disorder.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Stem Cell Research
volume
27
pages
4 pages
publisher
Elsevier
external identifiers
  • scopus:85040374604
ISSN
1873-5061
DOI
10.1016/j.scr.2018.01.002
language
English
LU publication?
yes
id
4a46a736-36f8-4bea-b3e0-1da986bbbd70
date added to LUP
2018-01-22 09:00:17
date last changed
2018-01-23 03:00:14
@article{4a46a736-36f8-4bea-b3e0-1da986bbbd70,
  abstract     = {<p>Skin fibroblasts were collected from a 44-year-old patient with sporadic case of Parkinson's disease (PD). The non-integrating Sendai virus vector encoding OCT3/4, SOX2, c-MYC and KLF4 was used to reprogram fibroblasts into induced pluripotent stem cells (iPSCs). Generated iPSCs had normal karyotypes, expressed common stem cell markers, and were capable of differentiating into all three germ layers. Generated line could be used for PD modeling to understand the mechanisms that influence the disorder.</p>},
  author       = {Savchenko, Ekaterina and Marote, Ana and Russ, Kaspar and Collin, Anna and Goldwurm, Stefano and Roybon, Laurent and Pomeshchik, Yuriy},
  issn         = {1873-5061},
  language     = {eng},
  month        = {03},
  pages        = {78--81},
  publisher    = {Elsevier},
  series       = {Stem Cell Research},
  title        = {Generation of a human induced pluripotent stem cell line (CSC-42) from a patient with sporadic form of Parkinson's disease},
  url          = {http://dx.doi.org/10.1016/j.scr.2018.01.002},
  volume       = {27},
  year         = {2018},
}