HLA-A*23 Is Associated With Lower Odds of Acute Retroviral Syndrome in Human Immunodeficiency Virus Type 1 Infection : A Multicenter Sub-Saharan African Study
(2024) In Open Forum Infectious Diseases 11(4).- Abstract
The role of human leukocyte antigen (HLA) class I and killer immunoglobulin-like receptor molecules in mediating acute retroviral syndrome (ARS) during human immunodeficiency virus type 1 (HIV-1) infection is unclear. Among 72 sub-Saharan African adults, HLA-A*23 was associated with lower odds of ARS (adjusted odds ratio, 0.10 [95% confidence interval, .01–.48]; P = .009), which warrants further studies to explore its role on HIV-1–specific immunopathogenesis.
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https://lup.lub.lu.se/record/4b176e80-4035-469a-ae8f-a2abcc08f06b
- author
- organization
- publishing date
- 2024
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- acute HIV infection, acute retroviral syndrome, Africa, HLA, KIR
- in
- Open Forum Infectious Diseases
- volume
- 11
- issue
- 4
- publisher
- Oxford University Press
- external identifiers
-
- pmid:38560608
- scopus:85189528453
- ISSN
- 2328-8957
- DOI
- 10.1093/ofid/ofae129
- language
- English
- LU publication?
- yes
- id
- 4b176e80-4035-469a-ae8f-a2abcc08f06b
- date added to LUP
- 2024-04-26 14:34:38
- date last changed
- 2024-06-07 18:52:44
@article{4b176e80-4035-469a-ae8f-a2abcc08f06b, abstract = {{<p>The role of human leukocyte antigen (HLA) class I and killer immunoglobulin-like receptor molecules in mediating acute retroviral syndrome (ARS) during human immunodeficiency virus type 1 (HIV-1) infection is unclear. Among 72 sub-Saharan African adults, HLA-A*23 was associated with lower odds of ARS (adjusted odds ratio, 0.10 [95% confidence interval, .01–.48]; P = .009), which warrants further studies to explore its role on HIV-1–specific immunopathogenesis.</p>}}, author = {{Lindquist, Lovisa and Kilembe, William and Karita, Etienne and Price, Matt A. and Kamali, Anatoli and Kaleebu, Pontiano and Tang, Jianming and Allen, Susan and Hunter, Eric and Gilmour, Jill and Rowland-Jones, Sarah L. and Sanders, Eduard J. and Hassan, Amin S. and Esbjörnsson, Joakim}}, issn = {{2328-8957}}, keywords = {{acute HIV infection; acute retroviral syndrome; Africa; HLA; KIR}}, language = {{eng}}, number = {{4}}, publisher = {{Oxford University Press}}, series = {{Open Forum Infectious Diseases}}, title = {{HLA-A*23 Is Associated With Lower Odds of Acute Retroviral Syndrome in Human Immunodeficiency Virus Type 1 Infection : A Multicenter Sub-Saharan African Study}}, url = {{http://dx.doi.org/10.1093/ofid/ofae129}}, doi = {{10.1093/ofid/ofae129}}, volume = {{11}}, year = {{2024}}, }