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HLA-A*23 Is Associated With Lower Odds of Acute Retroviral Syndrome in Human Immunodeficiency Virus Type 1 Infection : A Multicenter Sub-Saharan African Study

Lindquist, Lovisa ; Kilembe, William ; Karita, Etienne ; Price, Matt A. ; Kamali, Anatoli ; Kaleebu, Pontiano ; Tang, Jianming ; Allen, Susan ; Hunter, Eric and Gilmour, Jill , et al. (2024) In Open Forum Infectious Diseases 11(4).
Abstract

The role of human leukocyte antigen (HLA) class I and killer immunoglobulin-like receptor molecules in mediating acute retroviral syndrome (ARS) during human immunodeficiency virus type 1 (HIV-1) infection is unclear. Among 72 sub-Saharan African adults, HLA-A*23 was associated with lower odds of ARS (adjusted odds ratio, 0.10 [95% confidence interval, .01–.48]; P = .009), which warrants further studies to explore its role on HIV-1–specific immunopathogenesis.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
acute HIV infection, acute retroviral syndrome, Africa, HLA, KIR
in
Open Forum Infectious Diseases
volume
11
issue
4
publisher
Oxford University Press
external identifiers
  • pmid:38560608
  • scopus:85189528453
ISSN
2328-8957
DOI
10.1093/ofid/ofae129
language
English
LU publication?
yes
id
4b176e80-4035-469a-ae8f-a2abcc08f06b
date added to LUP
2024-04-26 14:34:38
date last changed
2024-06-07 18:52:44
@article{4b176e80-4035-469a-ae8f-a2abcc08f06b,
  abstract     = {{<p>The role of human leukocyte antigen (HLA) class I and killer immunoglobulin-like receptor molecules in mediating acute retroviral syndrome (ARS) during human immunodeficiency virus type 1 (HIV-1) infection is unclear. Among 72 sub-Saharan African adults, HLA-A*23 was associated with lower odds of ARS (adjusted odds ratio, 0.10 [95% confidence interval, .01–.48]; P = .009), which warrants further studies to explore its role on HIV-1–specific immunopathogenesis.</p>}},
  author       = {{Lindquist, Lovisa and Kilembe, William and Karita, Etienne and Price, Matt A. and Kamali, Anatoli and Kaleebu, Pontiano and Tang, Jianming and Allen, Susan and Hunter, Eric and Gilmour, Jill and Rowland-Jones, Sarah L. and Sanders, Eduard J. and Hassan, Amin S. and Esbjörnsson, Joakim}},
  issn         = {{2328-8957}},
  keywords     = {{acute HIV infection; acute retroviral syndrome; Africa; HLA; KIR}},
  language     = {{eng}},
  number       = {{4}},
  publisher    = {{Oxford University Press}},
  series       = {{Open Forum Infectious Diseases}},
  title        = {{HLA-A*23 Is Associated With Lower Odds of Acute Retroviral Syndrome in Human Immunodeficiency Virus Type 1 Infection : A Multicenter Sub-Saharan African Study}},
  url          = {{http://dx.doi.org/10.1093/ofid/ofae129}},
  doi          = {{10.1093/ofid/ofae129}},
  volume       = {{11}},
  year         = {{2024}},
}